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African-American women carry inherited genetic mutations that increase their risk for breast cancer

A high percentage of African-American women with breast cancer who were evaluated at a university cancer-risk clinic were found to carry inherited genetic mutations that increase their risk for breast cancer.

4 Jun 2013

People with type 2 diabetics, hypertension more likely to have obstructive sleep apnea: Study

The American Academy of Sleep Medicine is advising anyone with Type 2 diabetes or hypertension to be evaluated for sleep apnea by a board-certified sleep medicine physician. The recommendation comes as the group of international clinicians and researchers meets in Baltimore for SLEEP 2013, the foremost gathering of sleep experts annually.

4 Jun 2013

Aaxillary lymph node dissection and radiotherapy provide excellent regional control for patients with breast cancer

Final analysis of the EORTC 10981-22023 AMAROS (After Mapping of the Axilla: Radiotherapy Or Surgery?) trial has shown that both axillary lymph node dissection and axillary radiotherapy provide excellent regional control for breast cancer patients with a positive sentinel node biopsy

3 Jun 2013

Mathematical modeling proved critical in understanding latent stage of infections

Recurrent infection is a common feature of persistent viral diseases. It includes episodes of high viral production interspersed by periods of relative quiescence. These quiescent or silent stages are hard to study with experimental models. Mathematical analysis can help fill in the gaps.

3 Jun 2013

Researchers reveal how disease mutations affect the stability and function of Parkin protein

Researchers at the MRC Laboratory of Molecular Biology in the United Kingdom have determined the crystal structure of Parkin, a protein found in cells that when mutated can lead to a hereditary form of Parkinson's disease.

3 Jun 2013

GRACE study reports colored women are poorly represented in HIV drug trials

Enrollment of women in clinical trials of new anti-HIV drugs is extremely low, representing only about 15% of all treatment-experienced patients. For women of color it is even lower.

3 Jun 2013

Research suggests medullary thymic epithelial cells may have evolved from cortical-thymic TECs

Medullary thymic epithelial cells (mTECs) allow the thymus to ensure that the body's T cells are able to distinguish between potentially harmful foreign antigens and those that are produced by the body itself.

3 Jun 2013

It is possible to reduce salt content without reducing the taste

It is entirely possible to reduce the salt content in a range of foods by up to 30% without reducing the taste.

3 Jun 2013

Motorized hand-held tools are responsible for highest emissions of particulate matter, says stufy

Motorway maintenance workers are exposed to various harmful emissions. Surprisingly, motorised hand-held tools such as strimmers and chainsaws, rather than motorway traffic, are responsible for the highest emissions of particulate matter.

3 Jun 2013

Four lifestyle behaviors protect against coronary heart disease, say researchers

A large, multi-center study led by Johns Hopkins researchers has found a significant link between lifestyle factors and heart health, adding even more evidence in support of regular exercise, eating a Mediterranean-style diet, keeping a normal weight and, most importantly, not smoking.

3 Jun 2013

Growth factor helps hair follicles regenerate during wound healing process, say researchers

Researchers in the Perelman School of Medicine at the University of Pennsylvania have determined the role of a key growth factor, found in skin cells of limited quantities in humans, which helps hair follicles form and regenerate during the wound healing process.

3 Jun 2013

Majority of U.S. oncologists report satisfaction with careers, but still experience symptom of burnout

Even though a majority of U.S. oncologists report satisfaction with their careers, many say they have experienced at least one symptom of burnout, a Mayo Clinic-led study has found. The study was released during the American Society of Clinical Oncology's annual meeting in Chicago.

3 Jun 2013

Combination of ipilimumab and nivolumab drugs reduces tumor size in metastatic melanoma patients

The combination of the immunotherapy drug ipilimumab and the investigational antibody drug nivolumab led to long-lasting tumor shrinkage in more than half of patients with metastatic melanoma, according to results from a Phase I trial simultaneously published online on Sunday, June 2, in The New England Journal of Medicine and presented by Memorial Sloan-Kettering Cancer Center researchers at the 49th Annual Meeting of the American Society of Clinical Oncology (ASCO).

3 Jun 2013

Research: Bevacizumab fails to increase overall survival for glioblastoma patients

The angiogenesis inhibitor bevacizumab (Avastin) failed to increase overall survival (OS) or statistically significant progression-free survival (PFS) for glioblastoma patients in the frontline setting, according to research led by researchers at The University of Texas MD Anderson Cancer Center.

3 Jun 2013

Study: GLT1 protein plays a critical role in cocaine craving

A new study conducted by a team of Indiana University neuroscientists demonstrates that GLT1, a protein that clears glutamate from the brain, plays a critical role in the craving for cocaine that develops after only several days of cocaine use.

3 Jun 2013

Patients with type 2 diabetes have altered gut microbiota

Intestinal bacteria may have a greater influence on us than was previously thought. In a study published in the prestigious journal Nature on 29 May, researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden and Chalmers University of Technology, Sweden, show that patients with type 2 diabetes have an altered gut microbiota.

3 Jun 2013

Researchers solve two longstanding challenges in liver tissue engineering

Prometheus, the mythological figure who stole fire from the gods, was punished for this theft by being bound to a rock. Each day, an eagle swept down and fed on his liver, which then grew back to be eaten again the next day.

3 Jun 2013

MRIgFU ablation therapy reduces pain in 67% of patients with bone tumors

Patients with cancer that has spread to their bones are often treated with radiation therapy to reduce pain. But if that treatment doesn't work, or can't be used again, a second, effective option now exists.

3 Jun 2013

Human tumors with MET amplification respond to MET inhibitor drugs

A subset of colorectal cancers responds to anti-epidermal growth factor receptor (anti-EGFR) therapies, but develops resistance within months. Among cancers that develop resistance to anti-EGFR therapy, some showed overexpression of a gene called MET, according to a study published in the June issue of Cancer Discovery, a journal of the American Association for Cancer Research.

3 Jun 2013

Study finds HER2 irregularities in 14 different advanced solid tumors

The HER2 growth-factor gene is known to be over-active in breast and gastro-esophageal cancers. But now, irregularities in the genes's expression - among them mutations, amplifications, substitutions, and translocations - have been found in 14 different advanced solid tumors.

3 Jun 2013

Medical Research News

African-American women carry inherited genetic mutations that increase their risk for breast cancer

People with type 2 diabetics, hypertension more likely to have obstructive sleep apnea: Study

Aaxillary lymph node dissection and radiotherapy provide excellent regional control for patients with breast cancer

Mathematical modeling proved critical in understanding latent stage of infections

Researchers reveal how disease mutations affect the stability and function of Parkin protein

GRACE study reports colored women are poorly represented in HIV drug trials

Research suggests medullary thymic epithelial cells may have evolved from cortical-thymic TECs

It is possible to reduce salt content without reducing the taste

Motorized hand-held tools are responsible for highest emissions of particulate matter, says stufy

Four lifestyle behaviors protect against coronary heart disease, say researchers

Growth factor helps hair follicles regenerate during wound healing process, say researchers

Majority of U.S. oncologists report satisfaction with careers, but still experience symptom of burnout

Combination of ipilimumab and nivolumab drugs reduces tumor size in metastatic melanoma patients

Research: Bevacizumab fails to increase overall survival for glioblastoma patients

Study: GLT1 protein plays a critical role in cocaine craving

Patients with type 2 diabetes have altered gut microbiota

Researchers solve two longstanding challenges in liver tissue engineering

MRIgFU ablation therapy reduces pain in 67% of patients with bone tumors

Human tumors with MET amplification respond to MET inhibitor drugs

Study finds HER2 irregularities in 14 different advanced solid tumors

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