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Severe and necrotizing AP characterized by depletion of circulating lymphocytes

Mortality of patients with severe acute pancreatitis (SAP) approaches 30%-40%. An imbalance between the early systemic inflammatory response syndrome (SIRS), and the later compensatory counter-inflammatory response, and development of multiple organ failure (MOF) are considered to be the primary causes of morbidity and mortality in SAP. Excessive leukocyte activation (including neutrophils and monocyte-macrophage lineage) with cytokinemia play a critical role in the pathogenesis of pancreatitis and even more so, of the subsequent inflammatory response.

20 Apr 2010

Certain genetic mutations lead to Type 1 diabetes: The Scripps Research Institute

Scientists from The Scripps Research Institute have provided an answer to the 40-year-old mystery of how certain genetic mutations lead to Type 1 diabetes. This new molecular understanding could lead to novel therapies for Type 1 diabetes and other autoimmune diseases.

20 Apr 2010

Basal ganglia and cerebellum linked together to form integrated functional network: Researchers

Researchers at the University of Pittsburgh have found new evidence that the basal ganglia and the cerebellum, two important areas in the central nervous system, are linked together to form an integrated functional network. The findings are available online this week in the Proceedings of the National Academy of Sciences.

20 Apr 2010

Screening rates for skin cancer low among middle-aged and older Caucasian adults: CINJ study

Among people over 50, those who did not finish high school or have not recently had common cancer screenings such as a mammogram, prostate-specific antigen test or colorectal cancer screening, are also less likely to be screened for skin cancer.

20 Apr 2010

S1P5 may serve as future strategy in biotherapy for esophageal cancer: Study

Esophageal cancer is one of the most common malignancies worldwide. Its mortality is very high due to relatively late diagnosis and inefficient treatment. The ability to reverse the outcome of esophageal cancer is limited due to a poor understanding of its biology. Progression of esophageal cancer may be associated with sphingosine 1-phosphate and its receptors S1P1-5, which play an important role in other cancers.

20 Apr 2010

Meat cooked at high temperatures increases risk of developing bladder cancer

People who eat meat frequently, especially meat that is well done or cooked at high temperatures, may have a higher chance of developing bladder cancer, according to a large study at The University of Texas M. D. Anderson Cancer Center presented at the American Association for Cancer Research 101st Annual Meeting 2010. This risk appears to increase in people with certain genetic variants.

20 Apr 2010

KIKA Clinical Solutions, Carestream Health announce strategic knowledge transfer program

KIKA™ Clinical Solutions, the leader in advanced EDC solutions for Clinical Asset Management™, announced that Carestream Health, Inc., will work with KIKA to perform a knowledge transfer for use of KIKA's technology on six global clinical trials that require electronic data capture this year.

20 Apr 2010

Researchers use genistein to improve outlook of pancreatic cancer

Scientists at the Barbara Ann Karmanos Cancer Institute in Detroit today presented data at the American Association for Cancer Research's 101st Annual Meeting 2010 that shows when genistein, a component of soy, is paired with the FDA-approved drug oxaliplatin, pancreatic cancer cells become more sensitive to chemotherapy.

20 Apr 2010

Prognosis for IPMN depends on presence of extra-pancreatic cancer: Research

Intraductal papillary mucinous neoplasm of the pancreas shows a wide spectrum of histological presentations, ranging from adenoma with mild atypia to adenocarcinoma. In general, branch duct IPMN develops slowly and has a comparatively good prognosis. However, in several studies, it became evident that IPMN is a disease that very frequently coexists with cancer.

20 Apr 2010

IGF-IR plays role in proliferation and motility of pancreatic cancer cell lines: Research

Insulin-like growth factor-I is upregulated in human pancreatic cancer tissues but is not expressed in surrounding non-cancerous tissues. Serum level of IGF-I is elevated in pancreatic cancer patients. Histological analysis has shown that IGF-I receptor is positive in the membrane of pancreatic cancer tissues.

20 Apr 2010

Even modest weight loss brings many health benefits

There have been repeated warnings related to the growing obese and diabetes related population in Australia. Studies have shown that nearly 50% Australians are either obese or overweight and thus suffer from its ill effects like heart disease, high cholesterol and type II diabetes.

20 Apr 2010

Epileptic activity in brain can affect language development in children: Sahlgrenska Academy

Epileptic activity in the brain can affect language development in children, and EEG registrations should therefore be carried out more frequently on children with severe language impairment to identify more readily those who may need medical treatment, reveals a thesis from the Sahlgrenska Academy at the University of Gothenburg.

20 Apr 2010

Viral Genetics relocates research facilities to Georgetown

Biotech company Viral Genetics, Inc.,, is relocating its research facilities to the life science cluster in Georgetown, Texas. Lead scientist Dr. Karen Newell has joined the faculty of Texas A&M University's College of Medicine and has received a $750,000 grant to research bio-fuels from the Texas Emerging Technology Fund.

20 Apr 2010

New research shows link between infection-related diseases and risk of cancer

New research is emerging that suggests a link between infection-related diseases and risk of cancer, according to findings presented here at the American Association for Cancer Research 101st Annual Meeting 2010.

20 Apr 2010

HAMLET substance found in breast milk can kill cancer cells: Researchers

A substance found in breast milk can kill cancer cells, reveal studies carried out by researchers at Lund University and the University of Gothenburg, Sweden.

20 Apr 2010

Bruker launches new compact, high field NMR magnet series

At the 51st ENC, Bruker launches its new Ascend™ series of compact, high field NMR magnets to make high-field NMR even more powerful, and at the same time more convenient and accessible for numerous NMR laboratories. This new magnet line combines the key advantages of Bruker's well-established UltraShield™ Plus magnets, with further innovations for superior performance and greater convenience.

20 Apr 2010

PRA International expands clinical research operations to New Zealand

PRA International, a leading Clinical Research Organization, announces it has established a legal entity and hired staff in New Zealand, which will complement the firm's extensive network of Asia-Pacific operations and partnerships.

19 Apr 2010

Methotrexate therapy not recommended beyond 6 months after remission: JAMA

For patients with juvenile idiopathic arthritis in remission, withdrawal of treatment with the drug methotrexate over 12 months vs. 6 months did not reduce the rate of relapse, according to a study in the April 7 issue of JAMA.

19 Apr 2010

Hidden neuronal circuit that modulates sensory perception under stress identified

Did you ever wonder how you are able to perform complex tasks - even under stress? And how do emotions and memories mould your ability to live your everyday lives? The answer is just beginning to be understood and lies in hidden circuits in the brain.

19 Apr 2010

Exposure to dust after WTC collapse impairs ability to detect odors and sense irritants

Individuals involved in rescue, recovery, demolition, and clean-up after the World Trade Center (WTC) disaster on September 11, 2001, were exposed to a complex mixture of airborne smoke, dust, combustion gases, acid mists, and metal fumes. The impact of this exposure on responders' upper and lower respiratory function has been well documented, but little is known about its impact on their sensitivity to odor and irritants.

19 Apr 2010

Medical Research News

Severe and necrotizing AP characterized by depletion of circulating lymphocytes

Certain genetic mutations lead to Type 1 diabetes: The Scripps Research Institute

Basal ganglia and cerebellum linked together to form integrated functional network: Researchers

Screening rates for skin cancer low among middle-aged and older Caucasian adults: CINJ study

S1P5 may serve as future strategy in biotherapy for esophageal cancer: Study

Meat cooked at high temperatures increases risk of developing bladder cancer

KIKA Clinical Solutions, Carestream Health announce strategic knowledge transfer program

Researchers use genistein to improve outlook of pancreatic cancer

Prognosis for IPMN depends on presence of extra-pancreatic cancer: Research

IGF-IR plays role in proliferation and motility of pancreatic cancer cell lines: Research

Even modest weight loss brings many health benefits

Epileptic activity in brain can affect language development in children: Sahlgrenska Academy

Viral Genetics relocates research facilities to Georgetown

New research shows link between infection-related diseases and risk of cancer

HAMLET substance found in breast milk can kill cancer cells: Researchers

Bruker launches new compact, high field NMR magnet series

PRA International expands clinical research operations to New Zealand

Methotrexate therapy not recommended beyond 6 months after remission: JAMA

Hidden neuronal circuit that modulates sensory perception under stress identified

Exposure to dust after WTC collapse impairs ability to detect odors and sense irritants

The future of automation: Machine learning–driven hepatocyte and organoid counting

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

Reimagining light scattering for biotherapeutics

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