Medical Research News

RSS

New model predicts whether patients will be free of renal cancer 12 years after initial treatment

A UT Southwestern Medical Center physician and other researchers have developed a unique statistical model that predicts the probability of a patient being cancer free 12 years after initial surgical treatment.

2 Jun 2008

How advanced prostate cancer becomes resistant to androgen-deprivation therapy

For the past 70 years the treatment of choice for advanced, metastatic prostate cancer has been androgen-deprivation therapy. That is, the suppression of circulating testosterone - the hormone that fuels prostate-cancer growth - via surgical castration (orchiectomy) or medical castration with testosterone-blocking drugs. While such therapy buys time for patients, it is not a cure, as inevitably the cancer becomes resistant to the androgen deprivation and continues to grow.

2 Jun 2008

Survivors of childhood Hodgkin's lymphoma at higher risk of future health problems

Adults who survived childhood Hodgkin's Lymphoma should be especially vigilant about cancer and cardiovascular screenings, according to researchers from Wake Forest University Baptist Medical Center and colleagues.

2 Jun 2008

Researchers find gene signature profile for metastasis

A common signature of tiny, specific pieces of non-coding genetic material known as microRNAs (miRNAs) may be directly involved in the spread of cancer to other parts of the body.

2 Jun 2008

UT Southwestern mouse model mimics hyperglycemia, aids in diabetes research

UT Southwestern Medical Center researchers have genetically engineered a laboratory mouse in which pancreatic beta cells can regenerate after being induced to die. The new animal model's regenerative ability may provide future insights into improved treatments of diabetes, which affects millions of Americans.

2 Jun 2008

Potential hypophosphatasia therapy discovered

Researchers at the Burnham Institute for Medical Research, led by José Luis Millán, Ph.D., have demonstrated in mice the first successful use of enzyme replacement therapy to prevent hypophosphatasia (HPP), a primary skeletal disease of genetic origin. This discovery lays the foundation for future clinical trials for HPP patients.

1 Jun 2008

Novel chemo drug helps treat prostate cancer

Men with a certain type of prostate cancer have been shown to respond to a new chemotherapy drug, Sagopilone, plus prednisone in an international trial led by Oregon Health & Science University Cancer Institute researchers.

1 Jun 2008

Yale researchers block transforming growth factor to clear up amyloid plaques in mice

Blocking a common immune system response cleared up plaques associated with Alzheimer's Disease and enabled treated mice to recover some lost memory, Yale University researchers report Friday in the journal Nature Medicine.

1 Jun 2008

Researchers pinpoint gene mutations responsible for 10 percent of non-familial cases of schizophrenia

Scans of the genome of patients with schizophrenia have revealed rare spontaneous copy number mutations that account for at least 10 percent of the non-familial cases of the disease.

1 Jun 2008

Tumor suppressor genes speed up and slow down aging in engineered mouse

Mayo Clinic researchers have developed an animal model that can test the function of two prominent tumor suppressor genes, p16 and p19, in the aging process. Scientists knew that both these genes were expressed at increased levels as humans and mice age, but their role in the aging process was not clear. Findings by the Mayo team show that p16 provides gas to accelerate cellular aging, while p19 stops that process.

1 Jun 2008

X chromosome exposed

An enzyme that binds differently to male and female sex chromosomes helps males to make up for their X chromosome shortage.

30 May 2008

University of Bristol to test effectiveness of cognitive behavioural therapy

A team of researchers, led by Dr Nicola Wiles at the University of Bristol, has been awarded £1.2 million by the National Institute for Health Research Health Technology Assessment (NIHR HTA) programme for a clinical trial to investigate the effectiveness of cognitive behavioural therapy (CBT) for patients with depression who do not respond to treatment with antidepressants.

30 May 2008

Rett syndrome gene found to be full of surprises

A study funded by the National Institutes of Health (NIH) has transformed scientists' understanding of Rett syndrome, a genetic disorder that causes autistic behavior and other disabling symptoms. Until now, scientists thought that the gene behind Rett syndrome was an "off" switch, or repressor, for other genes. But the new study, published today in Science, shows that it is an "on" switch for a startlingly large number of genes.

29 May 2008

Body's baking soda used to catch cancer early

A chemical commonly called baking soda which is found naturally in the body could be used to detect cancer with magnetic resonance imaging, reveals a Cancer Research UK study published in Nature.

29 May 2008

New cancer stem cell identified behind metastatic tumors

The molecular profile of cancer stem cells that initiate metastatic colon tumors is significantly different from those responsible for primary tumors, according to new research from a team at Weill Cornell Medical College.

28 May 2008

Cancer Research UK creates 'crack teams' to solve cancer's greatest mysteries

World leading scientists are to be targeted by Cancer Research UK and its development and commercialisation arm Cancer Research Technology (CRT), in an effort to tackle some of cancer's most pressing scientific challenges.

28 May 2008

Scientists identify a brain mechanism underlying persistent cocaine craving

Scientists have identified a mechanism in the brain that helps to explain why craving for cocaine, and the risk of relapse, seems to increase in the weeks and months after drug use is stopped. The research was supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health.

28 May 2008

Why some treatments rescue aging skin

Fine wrinkles, deeper creases, saggy areas around the mouth and neck - the sights in the mirror that make baby boomers wince - are not inevitable. They result from a structural breakdown inside the skin that some existing treatments effectively counteract by stimulating the growth of new, youthful collagen, University of Michigan scientists say.

28 May 2008

Allergy - it's in the genes

In a world first scientists at theWestmead Millennium Institute have identified how a gene associated with allergic diseases such as asthma and eczema works, providing new hope for potential drug treatments.

28 May 2008

Global drug research programme comes to Diamond in Oxfordshire

Diamond has announced that USA-based global biotechnology company Vertex Pharmaceuticals Incorporated is the first industrial user at the UK's world class new research facility, Diamond Light Source

27 May 2008