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Comprehensive view of the abnormal genetic landscape in lung cancer cells

An international team of scientists has announced the results of a systematic effort to map the genetic changes underlying lung cancer, the world's leading cause of cancer deaths.

5 Nov 2007

Inheriting two genetic mutations that can individually cause epilepsy may cancel each other

Inheriting two genetic mutations that can individually cause epilepsy might actually be "seizure-protective," said Baylor College of Medicine researchers in a report that appears online in the journal Nature Neuroscience.

5 Nov 2007

Endosonography-guided biliary drainage is useful in cases with failed endoscopic biliary stenting

The role of endosonography (ES) in digestive diseases is expanding gradually from diagnostic applications to therapeutic ones. The feasibility of ES-guided cholangiopancreatography was first reported by Harada et al. (pancreatography) and Wiersema et al. (cholangiography) in 1995 and 1996, respectively.

5 Nov 2007

Does neural cell adhesion molecule-180 predict survival in colorectal cancer?

When a person learns they are suffering from cancer, the first question in their mind is always: "How much time do I have?" Unfortunately, this is a question to which the researchers have long been seeking an absolute answer.

5 Nov 2007

Manipulation of MOF enzyme may make tumors more sensitive to radiation therapy

To make tumors more sensitive to the killing power of radiation is a key aspiration for many radiation oncologists. Researchers at Washington University School of Medicine in St. Louis have uncovered new information that leads them closer to that goal.

5 Nov 2007

Carnegie Mellon researchers to develop new stem cell-based drug delivery therapy

Carnegie Mellon University's Stefan F. Zappe is using adult neural stem cells to develop a new stem cell-based drug delivery therapy that may ultimately help treat a variety of inherited genetic disorders like Hunter syndrome.

5 Nov 2007

Hairpin peptide mimetics show promise as new drugs to fight HIV

When a host cell is infected with HIV, the virus brings its own genetic material into the host cell. This cell then replicates, reads the viral RNA, and uses it as a blueprint to produce more viral proteins.

5 Nov 2007

Heart plays a losing game of catch-up as people age

Researchers at Johns Hopkins have evidence to explain why the supposedly natural act of aging is by itself a very potent risk factor for life-threatening heart failure.

5 Nov 2007

Antibody might help starve cancerous tumors

An antibody might offer a safe and effective complement to anti-cancer therapies designed to starve malignant tumors by pruning the blood vessels that feed them, researchers report in the November 2 issue of the journal Cell, a publication of Cell Press.

2 Nov 2007

The PIN codes of the immune system can be hacked

There are several reasons why the world is still plagued by diseases we cannot treat or vaccinate against, one of them being the vast complexity of the human immune system.

2 Nov 2007

Chemical peroxynitrite tolerates pain

The repeated use of opiate drugs such as morphine to relieve chronic pain results in individuals having to take higher and higher doses of the drug to achieve equivalent pain relief (they are said to exhibit antinociceptive tolerance).

2 Nov 2007

SENP1 protein may provide a basis for future targeted cancer therapies

Researchers at the University of Texas M. D. Anderson Cancer Center have found a protein that enables cellular survival during periods of low oxygen, or hypoxia, which also is key for development of many kinds of cancer.

2 Nov 2007

Psychological stress increases susceptibility to skin infections in mice

It is well known that being stressed increases our susceptibility to infections by impairing the function of our immune system, but the molecular links between stress and diminished immune function have not been determined.

2 Nov 2007

Research sheds light on carotid artery stenting risk in elderly

Dr. Hernan Bazan, Assistant Professor of Surgery, Section of Vascular Surgery, at Louisiana State University Health Sciences Center New Orleans' School of Medicine, is the lead author of a research paper which may help physicians decide which patients with carotid artery occlusive disease should have carotid surgery or carotid stenting.

2 Nov 2007

Enzyme sphingosine kinase 2 show to be potential new target to fight cancer

Researchers at the Virginia Commonwealth University Massey Cancer Center have identified the enzyme sphingosine kinase 2 as a possible new therapeutic target to improve the efficacy of chemotherapy for colon and breast cancer.

2 Nov 2007

Discovery of master switch that regulates blood pressure

A team of Oregon Health & Science University researchers studying a rare form of hypertension has identified the mechanism by which they believe a protein complex in the kidney operates as a master switch that regulates blood pressure, a finding that has broad implications for the treatment of more common forms of hypertension.

2 Nov 2007

New approach to peak flow monitoring

When it comes to asthma monitoring, the eye is the key; according to Associate Professor Helen Reddel, who has spent years researching and refining a new peak expiratory flow chart.

2 Nov 2007

Researchers find stem cells in degenerating spinal discs, potential for repair

Orthopedic researchers at Jefferson Medical College have for the first time found stem cells in the intervertebral discs of the human spine, suggesting that such cells might someday be used to help repair degenerating discs and remedy lower back and neck pain.

2 Nov 2007

Immune cell age plays role in retinal damage in age-related macular degeneration

Studying a mouse model of age-related macular degeneration, the leading cause of blindness in older Americans, scientists at Washington University School of Medicine in St. Louis have found age is key in determining whether damaging blood vessels will form beneath the retina and contribute to vision loss.

2 Nov 2007

Preventing Morphine tolerance

Tolerance to the pain-relieving effects of morphine - which builds rapidly with prolonged use - can be prevented by blocking a key substance that's formed when the drug is taken, researchers at the Saint Louis University School of Medicine have discovered.

2 Nov 2007