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X-ray crystallography images show how a protein called alpha-actinin performs molecular ballet

As a cell moves forward, physical stress on its skeleton triggers molecular fingers and arms to grasp each other in reinforcing links that stabilize the skeleton, according to images produced by investigators at St. Jude Children's Research Hospital.

12 Jul 2005

Giving oxygen may do more harm than good

Doctors and paramedics who give their patients oxygen - the most commonly administered "drug" in the world - may be doing more harm than good, a Queen's University researcher contends.

11 Jul 2005

Researchers find molecule ephrin-B3 inhibits regrowth of spinal nerve cells

A molecule that helps the body's motor nerve cells grow along proper paths during embryonic development also plays a major role in inhibiting spinal-cord neurons from regenerating after injury, researchers at UT Southwestern Medical Center have found.

11 Jul 2005

Size of the ventromedial prefrontal cortex (vmPFC) in the brain may be associated with the ability to recover emotionally from traumatic events

A new study by researchers from Massachusetts General Hospital (MGH) finds that an area called the ventromedial prefrontal cortex is thicker in volunteers who appear better able to modify their anxious response to memories of discomfort. The report will appear in the Proceedings of the National Academy of Science.

11 Jul 2005

Good news for curry wallahs, ingredient helps fight cancer

In good news for curry wallahs, researchers are saying that a compound that makes curry yellow could help fight skin cancer.

11 Jul 2005

Discovery of protein deficit that causes drug toxicity

Mayo Clinic researchers have discovered an inherited structural mechanism that can make drugs for some diseases toxic for some patients.

11 Jul 2005

Keap1 protein - a promising new target for drugs to fight many different kinds of cancer

Researchers at the University of Illinois at Chicago are unraveling the biochemical mechanism by which functional foods combat cancer.

11 Jul 2005

New understanding of degeneration of brain cells in patients with Alzheimer's, Huntington's, and Parkinson's diseases

A ground-breaking new research approach to understanding the cellular processes of Alzheimer's and other degenerative diseases has revealed a promising pathway to the development of new types of drugs for these diseases.

11 Jul 2005

Researchers discover genetically controlled brain mechanism responsible for social behavior in humans

Researchers at the National Institute of Mental Health (NIMH) have discovered a genetically controlled brain mechanism responsible for social behavior in humans - one of the most important but least understood aspects of human nature. The findings are reported in Nature Neuroscience.

11 Jul 2005

Researchers have discovered how p16 gene works

University of Minnesota researchers have discovered how a gene that suppresses the development of melanoma and other human cancers works. The study points the way to treatments based on the function of the gene.

11 Jul 2005

ASTRO awards nearly $400,000 in research grants

The American Society for Therapeutic Radiology and Oncology has announced the recipients of its 2005 Junior Faculty Career Research Training Award, Residents/Fellows in Radiation Oncology Research Seed Grants, the joint ASTRO/National Cancer Institute Fellowship Faculty Translational Research Award and International Travel Grants. The total value of the awards is $378,000.

11 Jul 2005

Lack of a blood clotting protein may protect against clogged arteries

Reporting in the July 18 issue of The Journal of Experimental Medicine, a group of scientists in Wurzburg, Germany show that the lack of a blood clotting protein may protect against clogged arteries with no risk of excessive bleeding.

11 Jul 2005

Newly discovered gene mutation may account for many cases of immune deficiency

...in particular two syndromes known as immunoglobulin A (IgA) deficiency and Common Variable Immunodeficiency (CVID), report researchers in the July issue of Nature Genetics. The discovery may lead to a new diagnostic test for these conditions, which make people highly susceptible to infections and often go unrecognized because of a lack of good tests.

11 Jul 2005

Research explains one of the fundamental mysteries of multiple sclerosis

Scientists have pinpointed a chemical messenger that frees some white blood cells from the body's normal constraints, allowing the cells to act like renegades that could damage nerves in the central nervous system. The work, to be published in the July 15 issue of the Journal of Immunology and just published on-line, helps explain one of the fundamental mysteries of multiple sclerosis (MS).

11 Jul 2005

New approach to preventing or reversing heart failure

Duke University Medical Center researchers have identified a new protein that plays a critical role in enabling the heart to respond to such external stimuli as exercise or stress, as well as in the progressive loss of heart function that is heart failure, the researchers said.

11 Jul 2005

Fat in the bloodstream linked to heart attacks

New research, by Dr. Sotirios Tsimikas of the University of California, San Diego, has produced the first convincing evidence that a type of fat in the bloodstream can trigger the earliest conditions that lead to clogged blood vessels, the highest cause of heart attacks.

7 Jul 2005

Findings shed light on the underlying mechanisms that cause hypertension

An enzyme known to cause hypertension increases blood pressure by activating tiny pores, or channels, in kidney cells that allow increased levels of sodium to be reabsorbed into the blood, researchers at UT Southwestern Medical Center have found.

6 Jul 2005

Researchers clarifiy role of Notch protein in T-cell development

Researchers at the University of Pennsylvania School of Medicine have recently clarified the role of the Notch protein in T-cell development. T cells are required for many aspects of immunity, including fighting viral infections, providing cancer surveillance, and regulating multiple aspects of the immune response.

6 Jul 2005

Patients suffering from oral cancer have increased levels of certain bacteria in their saliva

Six common species of bacteria were found at significantly higher levels in the saliva of patients with oral squamous cell carcinoma (OSCC) than in the saliva of healthy individuals.

6 Jul 2005

Researchers discover sections of the chromosomes of lung cancer cells where cancer-related genes may lurk

With equipment designed to probe the smallest segments of the genetic code, researchers at Dana-Farber Cancer Institute and collaborating institutions have found something much larger: sections of the chromosomes of lung cancer cells where cancer-related genes may lurk.

6 Jul 2005