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Researchers identify the role of a protein in hemoglobin gene silencing

Virginia Commonwealth University Massey Cancer Center researchers have identified the role of a protein in hemoglobin gene silencing that may one day be a potential target for the treatment of genetic blood disorders like sickle-cell anemia and beta-thalassemia on the molecular level.

11 Apr 2006

New model of p53 regulation has important implications for the development of anticancer drugs

Genetically engineered mice convinced scientists at the Salk Institute for Biological Studies that it was time to overhaul widely held beliefs about how a powerful tumor suppressor called p53 is controlled in cells. Their new model of p53 regulation has important implications for the development of anticancer drugs.

11 Apr 2006

Single dose of stem cells produce robust behavioral recovery in animal models for stroke, cerebral palsy

A single dose of adult donor stem cells given to animals that have neurological damage similar to that experienced by adults with a stroke or newborns with cerebral palsy can significantly enhance recovery from these types of injuries, researchers say.

11 Apr 2006

Research explains why recipients of growth hormone therapy may develop colon polyps

The use of growth hormone therapy has been linked in some people to the development of colon polyps, a possible precursor to colorectal cancer - but medical researchers have debated the extent of a cancer risk.

11 Apr 2006

DNA "dark state" findings help explain evolution of life

Chemists at Oregon State University have pioneered a controversial theory about how supposedly-stable DNA bases can be pushed into a "dark state" in which they are highly vulnerable to damage from ultraviolet radiation - an idea that has challenged some of the most basic concepts of modern biochemistry.

11 Apr 2006

St. John's wort and Echinacea increase activity of enzyme in the liver and intestine

St. John's wort and Echinacea, two widely-used herbal preparations, have been found to increase activity of a specific enzyme in the liver and intestine, an enzyme involved in the metabolization of roughly one in every four pharmaceutical drugs on the market today, reports a clinical pharmacologist at Indiana University School of Medicine.

11 Apr 2006

Targeted mutations in mice uncover two key molecular events linked to learning

Johns Hopkins researchers have used mouse mutants to define critical steps involved in learning basic motor skills. The study focuses on the behavior of two proteins and the specific steps they take to control a neuron's ability to learn by adapting to signals from other nerve cells.

11 Apr 2006

Scientists identify a new gene that causes the spread of cancer

Professor Philip Rudland, Dr Guozheng Wang and Dr Roger Barraclough from Liverpool University's Cancer and Polio Research Fund Laboratories have discovered an additional member of the S100 family of protein genes - S100P - that causes the spread of cancerous cells from an original tumour to other parts of the body.

11 Apr 2006

Lubricin research points to future therapies for osteoarthritis

New evidence to explain how the body's natural joint lubricant prevents the wear and tear that can lead to osteoarthritis has been uncovered by researchers at Duke University's Pratt School of Engineering.The findings may lead to new methods for treating arthritis, the researchers said.

11 Apr 2006

Men's and women's brains behave differently

A key part of the brain involved in processing emotionally-influenced memories acts differently in men and women, even in the absence of stimuli, UC Irvine researchers have found.

11 Apr 2006

Gene variant doubles risk for obsessive-compulsive disorder

Scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) have identified a previously unknown gene variant that doubles an individual's risk for obsessive-compulsive disorder (OCD).

11 Apr 2006

Researchers identify critical human cell surface molecule involved in infection by Kaposi's sarcoma herpesvirus

Researchers at the National Institute of Allergy and Infectious Disease (NIAID) have identified a critical human cell surface molecule involved in infection by Kaposi's sarcoma herpesvirus (KSHV), the virus that causes Kaposi's sarcoma and certain forms of lymphoma.

11 Apr 2006

Researchers unravel structure of important new drug target that could potentially treat SARS-infected patients

Mesecar said that the knowledge gained from this new atomic structure - the first-ever reported on this class of proteases - has the potential to go beyond the treatment of patients infected with the coronavirus that causes SARS.

11 Apr 2006

Colorimetric screening detects DNA, small molecules and proteins

Using the unusual color properties of gold at the nanoscale, scientists at Northwestern University have developed a "litmus test" for DNA and small molecule binding that eventually could be used by pharmaceutical companies to rapidly identify promising candidates for new anti-cancer drugs.

11 Apr 2006

Researchers identify new disorder called cortical dysplasia-focal epilepsy syndrome

Researchers from the Translational Genomics Research Institute (TGen) and the Clinic for Special Children (CSC) in Strasburg, PA, have described a new childhood-onset disorder characterized by severe epilepsy and autistic traits, and identified its genetic basis.

11 Apr 2006

Leptin may lead to new approaches for curbing appetite

Hot fudge sundaes and french fries aside, new research suggests obesity is due at least in part to an attraction between leptin, the hormone that signals the brain when to stop eating, and a protein more recently associated with heart disease.

11 Apr 2006

Guidelines for medication withdrawal

Although thousands of scientific papers evaluate and compare new and established drugs each year, providing evidence to help doctors prescribe safe and effective doses, almost no studies focus on when or how to stop these medications, even late in life.

11 Apr 2006

Seniors cite financial need as the greatest barrier to receiving dental care

A survey of seniors' access to dental care conducted by researchers at the University at Buffalo and Buffalo State College presents a sobering picture of the dental needs and barriers to dental care experienced by seniors.

11 Apr 2006

Scientists use corrective gene to block a protein in the kidneys that triggers high blood pressure

Nearly one-third of American adults have high blood pressure, a major cause of heart attacks, strokes and kidney failure. But a new technique tested at the University of Florida could prove to be a long-term way to treat the disorder in humans, researchers say.

11 Apr 2006

Scientists find that growth hormone is produced in the brain

Scientists have found that growth hormone, a substance that is used for body growth, is produced in the brain, according to an article published in the Proceedings of the National Academy of Sciences.

11 Apr 2006

Medical Research News

Researchers identify the role of a protein in hemoglobin gene silencing

New model of p53 regulation has important implications for the development of anticancer drugs

Single dose of stem cells produce robust behavioral recovery in animal models for stroke, cerebral palsy

Research explains why recipients of growth hormone therapy may develop colon polyps

DNA "dark state" findings help explain evolution of life

St. John's wort and Echinacea increase activity of enzyme in the liver and intestine

Targeted mutations in mice uncover two key molecular events linked to learning

Scientists identify a new gene that causes the spread of cancer

Lubricin research points to future therapies for osteoarthritis

Men's and women's brains behave differently

Gene variant doubles risk for obsessive-compulsive disorder

Researchers identify critical human cell surface molecule involved in infection by Kaposi's sarcoma herpesvirus

Researchers unravel structure of important new drug target that could potentially treat SARS-infected patients

Colorimetric screening detects DNA, small molecules and proteins

Researchers identify new disorder called cortical dysplasia-focal epilepsy syndrome

Leptin may lead to new approaches for curbing appetite

Guidelines for medication withdrawal

Seniors cite financial need as the greatest barrier to receiving dental care

Scientists use corrective gene to block a protein in the kidneys that triggers high blood pressure

Scientists find that growth hormone is produced in the brain

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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