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Novel peptide-drug conjugate enhances the efficacy of immunotherapy in preclinical cancer models

A peptide-drug conjugate that targets the acidic environment of cancer cells enhanced the efficacy of immune checkpoint inhibitors in preclinical cancer models, according to results presented at the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics, held October 7-10, 2021.

7 Oct 2021

Study uncovers new drug target for myelodysplastic syndrome

Mount Sinai and UC San Diego researchers have shown for the first time how mutations affecting a cellular process called RNA splicing alter cells to develop myelodysplastic syndrome (MDS) and other hematologic malignancies and solid tumors, according to a study published in Cancer Discovery in October.

7 Oct 2021

Existing drug reduces obesity and fatty liver in mice without changes in food intake or daily activity

Researchers at Johns Hopkins Medicine have found that a drug first developed to treat Alzheimer's disease, schizophrenia and sickle cell disease reduces obesity and fatty liver in mice and improves their heart function — without changes in food intake or daily activity.

7 Oct 2021

Accumulation of amyloid beta and reduction of serotonin may trigger late-life depression

Looking for ways to image the human brain for the earliest signs of aging and cognitive decline, Johns Hopkins Medicine researchers recently identified a pattern that links the accumulation of amyloid beta (Aβ) proteins (associated with cognitive decline later in life) with a reduction of serotonin, the brain chemical that improves mood.

7 Oct 2021

Altering the metabolism of macrophages improves recovery after neve injury in mice

Peripheral nerves — the nerves outside the brain and spinal cord — have the capacity for regeneration, but the rate of renewal is so slow that many nerve injuries lead to incomplete recovery and permanent disability for patients.

7 Oct 2021

Abnormal T cell responses to COVID-19 do not appear to be the cause of MIS-C in children

Multisystem inflammatory syndrome in children (MIS-C) is a serious condition associated with a recent COVID-19 infection.

7 Oct 2021

Deadly subtype of T-cell lymphoma harbors unique mutations

An especially deadly subtype of T-cell lymphoma is distinguished by unique mutations in a specific protein signaling pathway, according to a study published in the journal Blood.

7 Oct 2021

New technology shows great promise for early diagnosis of Alzheimer’s disease

A technology developed by scientists at Lawrence Berkeley National Laboratory (Berkeley Lab) shows great promise for diagnosing Alzheimer's disease before symptoms arise, potentially changing the course of research and treatment for this condition, which affects millions of people worldwide and is estimated to be the sixth leading cause of death in the United States.

7 Oct 2021

Researcher calls for a broader and more inclusive definition of infertility

Academy Research Fellow Jukka Kekäläinen from the University of Eastern Finland calls for a broader and more inclusive definition of infertility in a recent opinion piece published in the journal Human Reproduction last week.

7 Oct 2021

Potent extended anti- SARS-CoV-2 effect of titanium dioxide surface coatings

A team of researchers has explored the possibility of coating surfaces with TiO2 as a tool to inactivate SARS-CoV-2.

7 Oct 2021

Critical function of IL-7 in diagnosis, prognosis, and treatment of COVID-19 patients

In this review, researchers summarized the therapeutic and pathogenic role of IL-7 in patients with COVID-19 and examined the promising role of IL-7 as a vaccine adjuvant.

7 Oct 2021

COVID-19 vaccinations associated with reduction of COVID-19 infections and deaths among Medicare beneficiaries

A study identified associations between COVID-19 infections, hospitalizations, and deaths among Medicare FFS beneficiaries and the fully vaccinated population at the county level.

7 Oct 2021

non-RBD mutation in SARS-CoV-2 variants enhances resistance to neutralizing antibodies

Researchers from Ohio State University have been investigating mutations in the rest of the spike protein, particularly the Q677H mutation.

7 Oct 2021

Scientists develop a cell-free assay to screen SARS-CoV-2 entry inhibitors

Scientists have developed and validated a cell-free fluorescence assay for the rapid screening of protein inhibitors.

7 Oct 2021

Study suggests continued delta variant outbreaks unless vaccination reaches high coverage levels in adults and children

Researchers have conducted a mathematical modeling study to understand how expanding vaccination to younger age groups may reduce the increasing case numbers.

7 Oct 2021

Study identifies factors that make transgender, gender expansive adults more or less likely to smoke

While rates of cigarette smoking among adults in the United States have declined significantly over the past several decades, tobacco use disparities remain among some population groups and disproportionately affect members of vulnerable communities.

7 Oct 2021

Scientists identify a new method to treat triple-negative breast cancer

A team of clinicians and scientists from the National Cancer Centre Singapore (NCCS), Singapore General Hospital (SGH) and A*STAR's Genome Institute of Singapore (GIS) has identified a novel method to treat triple-negative breast cancer (TNBC). They discovered that cancer cells switch between different cell states and are able to change from being less aggressive ('epithelial') to being more aggressive ('mesenchymal'), and vice versa.

7 Oct 2021

Massage can enhance healing and strength of muscles, study finds

Massage has been used to treat sore, injured muscles for more than 3,000 years, and today many athletes swear by massage guns to rehabilitate their bodies. But other than making people feel good, do these "mechanotherapies" actually improve healing after a severe injury? According to a new study from researchers at Harvard's Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences (SEAS), the answer is "yes."

7 Oct 2021

Newly developed gel helps improve the effectiveness of immunotherapy in glioblastoma

Pairing a newly developed gel with immunotherapy that was delivered to post-surgical mouse brains with glioblastoma, a highly malignant and deadly cancer, improved the immunotherapy's effectiveness, report researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and colleagues. The findings appeared on Oct. 6, 2021, in Science Advances.

7 Oct 2021

Tiny bubbles show promise for reducing inflammation

Scientists hope that tiny sacs of material excreted by cells - so-called extracellular vesicles - can be used to deliver drugs inside the body. Researchers at Karolinska Institutet now show that these nano-bubbles can transport protein drugs that reduce inflammation caused by different diseases.

6 Oct 2021

Medical Science News

Novel peptide-drug conjugate enhances the efficacy of immunotherapy in preclinical cancer models

Study uncovers new drug target for myelodysplastic syndrome

Existing drug reduces obesity and fatty liver in mice without changes in food intake or daily activity

Accumulation of amyloid beta and reduction of serotonin may trigger late-life depression

Altering the metabolism of macrophages improves recovery after neve injury in mice

Abnormal T cell responses to COVID-19 do not appear to be the cause of MIS-C in children

Deadly subtype of T-cell lymphoma harbors unique mutations

New technology shows great promise for early diagnosis of Alzheimer’s disease

Researcher calls for a broader and more inclusive definition of infertility

Potent extended anti- SARS-CoV-2 effect of titanium dioxide surface coatings

Critical function of IL-7 in diagnosis, prognosis, and treatment of COVID-19 patients

COVID-19 vaccinations associated with reduction of COVID-19 infections and deaths among Medicare beneficiaries

non-RBD mutation in SARS-CoV-2 variants enhances resistance to neutralizing antibodies

Scientists develop a cell-free assay to screen SARS-CoV-2 entry inhibitors

Study suggests continued delta variant outbreaks unless vaccination reaches high coverage levels in adults and children

Study identifies factors that make transgender, gender expansive adults more or less likely to smoke

Scientists identify a new method to treat triple-negative breast cancer

Massage can enhance healing and strength of muscles, study finds

Newly developed gel helps improve the effectiveness of immunotherapy in glioblastoma

Tiny bubbles show promise for reducing inflammation

Obesity, GLP-1s, and metabolic care

Automation in cell-based workflows

Data management challenges in scientific research

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