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Gene mutations in the ClC-2 chloride channel cause high blood pressure, kidney damage

When the adrenal gland produces too much aldosterone, this often leads to high blood pressure and kidney damage (hyperaldosteronism). It has only recently emerged that several patients harbor a mutation in the gene for the ClC-2 chloride channel.

15 Oct 2019

Researchers reveal mechanism involved in altering DNA methylation in cancer

Understanding the mechanisms that mediate widespread DNA damage in the cancer genome is of great interest to cancer physicians and scientists because it may lead to improved treatments and diagnosis. In this study, a multi-institutional team led by researchers at Baylor College of Medicine has brought attention to genomic structural variation as a previously unappreciated mechanism involved in altering DNA methylation, a form of gene control, in human cancers.

15 Oct 2019

Study suggests new model of treatment for heart attack or stroke victims

Each year, heart attacks kill almost 10 million people in the world, and more than 6 million die from stroke. A heart attack is caused by a clot that blocks the artery blood flow. Unirrigated tissues are deprived from the oxygen that is carried by the blood. Under these conditions, the affected tissues undergo a rapid necrosis.

15 Oct 2019

Discovery could lead to new therapeutic targets for neurodegenerative diseases

Research led by Drs. Miguel Burguillos (University of Seville, Spain) and Miguel Branco (Queen Mary University of London, UK), has revealed new findings about mechanisms regulating brain inflammation which open a new pathway in the field of neuroinflammation.

15 Oct 2019

Finnish study offers new information about molecular mechanisms of Alzheimer's disease

Researchers have discovered new changes in blood samples associated with Alzheimer's disease. A new international study was conducted on disease-discordant Finnish twin pairs: one sibling suffering from Alzheimer's disease and the other being cognitively healthy.

15 Oct 2019

New cancer treatment developed at Yale

Scientists at Yale have developed a method that assists the immune system in identifying and eliminating cancer cells that may be missed by other forms of immunotherapies.

15 Oct 2019

Ludwig scientists develop robust method to refine personalized cancer immunotherapy

Ludwig Cancer Research scientists have developed a new and more accurate method to identify the molecular signs of cancer likely to be presented to helper T cells, which stimulate and orchestrate the immune response to tumors and infectious agents.

14 Oct 2019

Dementia spreads via synaptic connections between brain networks

In a new study, UC San Francisco scientists used maps of brain connections to predict how brain atrophy would spread in individual patients with frontotemporal dementia, adding to growing evidence that the loss of brain cells associated with dementia spreads via the synaptic connections between established brain networks.

14 Oct 2019

Default response to spinal disc injuries can be temporarily stopped to allow for better treatment

Researchers may have found a way to press pause on spinal disc injuries, giving doctors more time to treat them before worse issues develop.

14 Oct 2019

New system can help the immune system spot and eliminate tumors

Cancer cells are masters at avoiding detection, but a new system developed by Yale scientists can make them stand out from the crowd and help the immune system spot and eliminate tumors that other forms of immunotherapies might miss, the researchers report Oct. 14 in the journal Nature Immunology.

14 Oct 2019

Blood vessel damage is more widespread than expected in patients with TBI

The effects of a traumatic brain injury are pretty clear – problems with memory, headaches, and emotions – but what's unclear is the underlying pathological causes for those symptoms.

14 Oct 2019

New Penn Medicine study unravels the early makings of an exhausted T cell

The immune system struggles to defeat cancer or chronic infections because many of the T cells that leap into action end up "exhausted," rendering them ineffective against disease.

14 Oct 2019

Committee calls for cheese products to display warning about breast cancer

The Physicians Committee for Responsible Medicine has called for the Food and Drug Administration (FDA) to push for cheese manufacturers to place breast cancer warning labels on their products.

14 Oct 2019

Combination of two drugs disrupts cancer cells' ability to survive DNA damage, study finds

In continuing efforts to find novel ways to kill cancer cells, researchers at the University of Maryland School of Medicine have identified a new pathway that leads to the destruction of cancer cells.

14 Oct 2019

Poor paternal diet may impact the heart health of offspring

When trying to get pregnant, couples often change their lifestyles, going on crash diets or taking up stricter exercise regimens. New research, done on mice, suggests that men might be best off avoiding crash diets, as it may affect the heart health of their offspring.

14 Oct 2019

New study could change the way traumatic brain injuries are treated

Traumatic brain injuries, including concussions, can be caused by anything from sports injuries to battlefield trauma.

14 Oct 2019

Brain protein plays a prominent role in the maintenance of chronic pain

A protein called RGS4 (Regulator of G protein signaling 4) plays a prominent role in the maintenance of long-term pain states and may serve as a promising new target for the treatment of chronic pain conditions, according to research conducted at the Icahn School of Medicine at Mount Sinai and published in print October 16, in The Journal of Neuroscience.

11 Oct 2019