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Castration-resistant metastatic prostate cancer responds to combination of immune checkpoint inhibitors

Some patients with metastatic prostate cancer respond to a combination of immune checkpoint inhibitors after hormonal therapy and chemotherapy have failed, according to early results from a clinical trial led by investigators at The University of Texas MD Anderson Cancer Center presented today at the American Society of Clinical Oncology Genitourinary Cancers Symposium in San Francisco.

15 Feb 2019

Immune checkpoint molecule protects against future development of cancer

A research team at the University of Louisville has discovered that an immune checkpoint molecule they developed for cancer immunotherapy, also protects against future development of multiple types of cancer when administered by itself.

15 Feb 2019

New method for improved visualization of single-cell RNA- sequencing data

Like going from a pinhole camera to a Polaroid, a significant mathematical update to the formula for a popular bioinformatics data visualization method will allow researchers to develop snapshots of single-cell gene expression not only several times faster but also at much higher-resolution.

15 Feb 2019

Newly developed stem cell technologies show promise for treating PD patients

Cell replacement may play an increasing role in alleviating the motor symptoms of Parkinson's disease (PD) in future. Writing in a special supplement to the Journal of Parkinson's Disease, experts describe how newly developed stem cell technologies could be used to treat the disease and discuss the great promise, as well as the significant challenges, of stem cell treatment.

15 Feb 2019

Suspicious spots on the lungs of children with rhabdomyosarcoma do not behave like metastases

Rhabdomyosarcoma is a malignant soft tissue tumor in the muscle tissue of children and adolescents. About 20 children are diagnosed with rhabdomyosarcoma per year in the Netherlands. "Metastases in these children are often found in the lungs," says professor Hans Merks of the Princess Máxima Center for Pediatric Oncology, who led the study.

15 Feb 2019

Moffitt researchers shed light on how CAR T cells function mechanistically

The scientific community has made great strides over the past decade in the development of a new class of cancer therapy called immunotherapy, a treatment that activates a patient's own immune system to target cancer cells.

15 Feb 2019

Brain synchronization depends on the language of communication

Experts from the Basque research center BCBL have shown for the first time that the way in which the activity of two brains is connected depends on whether the dialogue takes place in the native language or in a foreign language.

15 Feb 2019

New therapeutic molecules show promise in reversing memory loss related to depression, aging

New therapeutic molecules developed at Toronto's Centre for Addiction and Mental Health show promise in reversing the memory loss linked to depression and aging.

15 Feb 2019

Blood-brain barrier disruption could lead to age-related cognitive decline

As our brains age, we become more forgetful, more tired and less able to do the cognitive gymnastics of our youth.

15 Feb 2019

Genetic variations in a fourth gene associated with higher ALL risk in Hispanic children

St. Jude Children's Research Hospital scientists have identified genetic variations in a fourth gene that are associated with an increased risk of acute lymphoblastic leukemia in Hispanic children. The research appears today in the journal Blood.

15 Feb 2019

Study: General anesthesia in early infancy unlikely to have lasting effects on developing brains

A single hour of general anesthesia in early infancy—longer than is necessary to perform the most common types of minor surgeries in childhood—does not result in measurable neurodevelopmental or behavioral problems up to the age of 5 years, according to the first randomized trial of its kind involving 722 infants in seven countries, published in The Lancet.

15 Feb 2019

Cell manipulation could soon halt or reverse aging

Researchers have shown that tweaking the tiny inner parts of a cell could prevent the damage caused due to aging.

15 Feb 2019

Lifetime adversity, increased neural processing during trauma combine to intensify core PTSD symptoms

Lifetime adversity and increased neural processing during a traumatic event combine to increase the frequency of intrusive traumatic memories and the distress they cause, according to a new study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

14 Feb 2019

Social threat learning has a strong effect on our decision-making

Learning what is dangerous by watching a video or being told (known as social learning) has just as strong an effect on our decision-making as first-hand experience of danger, researchers at Karolinska Institutet in Sweden report.

14 Feb 2019

Researchers identify brain pathways of aversion

What happens in the brain when we feel discomfort? Researchers at Karolinska Institutet in Sweden are now one step closer to finding the answer. In a new study published in the journal Molecular Psychiatry they identify which pathways in the mouse brain control behavior associated with aversion.

14 Feb 2019

Medical Science News

Castration-resistant metastatic prostate cancer responds to combination of immune checkpoint inhibitors

Immune checkpoint molecule protects against future development of cancer

New method for improved visualization of single-cell RNA- sequencing data

Newly developed stem cell technologies show promise for treating PD patients

Suspicious spots on the lungs of children with rhabdomyosarcoma do not behave like metastases

Moffitt researchers shed light on how CAR T cells function mechanistically

Brain synchronization depends on the language of communication

New therapeutic molecules show promise in reversing memory loss related to depression, aging

Blood-brain barrier disruption could lead to age-related cognitive decline

Genetic variations in a fourth gene associated with higher ALL risk in Hispanic children

Study: General anesthesia in early infancy unlikely to have lasting effects on developing brains

Cell manipulation could soon halt or reverse aging

Lifetime adversity, increased neural processing during trauma combine to intensify core PTSD symptoms

Social threat learning has a strong effect on our decision-making

Researchers identify brain pathways of aversion

Outpatient cleaning regimen cuts MRSA infection by a third

Female reproductive tract blocks weak sperm from reaching egg

Longer-lived sperm produces offspring with healthier lifespans

Breakthrough study highlights the promise of cell therapies for muscular dystrophy

New reversible antiplatelet therapy could reduce risk of blood clots, prevent cancer metastasis

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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