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Heating tumors during CAR T-cell therapy can enhance treatment's success, study suggests

A preclinical study led by scientists at the UCLA Jonsson Comprehensive Cancer suggests that heating solid tumors during CAR T-cell therapy can enhance the treatment's success.

28 Mar 2019

New medication increases muscle and bone mass in mice

It is common knowledge that as people grow older they lose a large part of their muscle mass - and neither are their bones what they once were. Researchers from Aarhus University, Denmark, working together with researchers at Erasmus Medical Center in Rotterdam have now studied a new group of medication which could prove beneficial for the elderly and the chronically ill who suffer a loss of bone- and muscle mass.

28 Mar 2019

Radiolabeled protein lights up tumor to reveal where cancer drugs are working

Experimenting with mice, Johns Hopkins researchers report they have successfully used positron emission tomography scans to calculate in real time how much of an immunotherapy drug reaches a tumor and what parts of a cancer remain unaffected.

28 Mar 2019

Using gene therapy strategies to rejuvenate aging cells and treat osteoarthritis

Aging is a risk factor for the development of osteoarthritis (OA), a chronic disease characterized by degeneration of articular cartilage leading to pain and physical disability.

28 Mar 2019

Just one dose of glucose while on keto diet can damage blood vessels

The often embraced 'cheat day' is a common theme in many diets and the popular ketogenic diet is no exception. But new research from UBC's Okanagan campus says that just one 75-gram dose of glucose--the equivalent a large bottle of soda or a plate of fries--while on a high fat, low carbohydrate diet can lead to damaged blood vessels.

28 Mar 2019

Researchers develop new technology to mass produce cerebral cortex neurons

Korea Brain Research Institute (KBRI, President Pann Ghill Suh) announced on Mar. 4 that its research team led by principal researcher Yoichi Kosodo developed a technology to mass produce cerebral cortex neurons utilizing Induced pluripotent Stem Cells.

28 Mar 2019

Garvan researchers develop more accurate method to diagnose cancer subtypes

Developed by researchers at the Garvan Institute of Medical Research, this potential diagnostic method screens a cancer sample for 'fusion genes', estimated to be linked to one in five cancers, and may provide a more accurate snapshot of rearranged DNA found in cancer.

28 Mar 2019

Study sheds light on why some people hear 'hear' silent flashes or movement

A synaesthesia-like effect in which people 'hear' silent flashes or movement, such as in popular 'noisy GIFs' and memes, could be due to a reduction of inhibition of signals that travel between visual and auditory areas of the brain, according to a new study led by researchers at City, University of London.

28 Mar 2019

Vitamin C can reduce the length of ICU stay

Vitamin C administration shortened the length of stay in the intensive care unit on average by 8% in 12 trials with 1766 patients according to a meta-analysis published in Nutrients.

28 Mar 2019

Exercise helps prevent cartilage degradation caused by osteoarthritis, study shows

Exercise helps to prevent the degradation of cartilage caused by osteoarthritis, according to a new study from Queen Mary University of London.

27 Mar 2019

C-Path and Japan's PMDA join forces on first-of-its-kind biomarker project

Critical Path Institute announced today that a formal consultation between its Predictive Safety Testing Consortium and Japan's Pharmaceuticals and Medical Devices Agency has resulted in an agreement on a first-of-its-kind approach to compare the levels of eight novel urinary kidney safety biomarkers in healthy Japanese volunteers to data collected on these same biomarkers in healthy Western volunteers in a bridging study.

27 Mar 2019

Researchers discover underlying cause of hereditary muscle disease

Researchers at Karolinska Institutet have discovered the underlying cause of a hereditary muscle disease first characterised in a Swedish family in 1980. It proves to be the first identified disease caused by defective myoglobin, the protein that transports oxygen in muscle cells.

27 Mar 2019

Synthetic alcohol substitute could make hangovers a thing of the past

Professor David Nutt is aiming to make hangovers a thing of the past by introducing a synthetic alcohol alternative named "alcosynth".

27 Mar 2019

People born with short telomeres found to have short-lived immune system cells

Scientists at Johns Hopkins say they have found that people born with abnormally short chromosome endcaps, or telomeres, have immune system cells that age and die prematurely.

27 Mar 2019

Coating medical implant surfaces with microgel flecks could help reduce infection rates

Joint replacements are among the most common elective surgeries -- but around one in 100 patients suffer post-surgical infections, turning a routine procedure into an expensive and dangerous ordeal.

27 Mar 2019

Health risks linked with cocktail of man-made chemicals are overlooked

The cocktail of man-made chemicals that we are exposed to daily is a health risk which current regulations and risk assessment overlook. This is the conclusion of the EU Horizon 2020 EDC-MixRisk project that is now being presented.

27 Mar 2019

Using connectomics to gain insight into epilepsy

Abnormalities in structural brain networks and how brain regions communicate may underlie a variety of disorders, including epilepsy, which is one focus of a two-part Special Issue on the Brain Connectome in Brain Connectivity, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

27 Mar 2019

Tumor-associated macrophages block activity of chemotherapy drug in pancreatic cancer

A frontline chemotherapy drug given to patients with pancreatic cancer is made less effective because similar compounds released by tumor-associated immune cells block the drug's action, research led by the University of Michigan Rogel Cancer Center found.

27 Mar 2019

Study offers new insights for vaccine development to prevent RSV disease

In healthy adults, RSV, or respiratory syncytial virus, feels like the common cold with a runny nose, chest congestion and cough.

27 Mar 2019

Simple parameter can help surgeons in making decisions to treat aneurysms

Aneurysms form as abnormal bulges or balloonings over an artery, and, if ruptured, can lead to serious health complications or even death. Some aneurysms can exist for a long time without rupturing, and the surgery involved in treating aneurysms can be quite risky, so a parameter to help guide surgeons is needed.

27 Mar 2019