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Researchers find crucial inhibitory role for signal peptide in GluK1 trafficking

Glutamate is the major excitatory neurotransmitter in the brain, and the postsynaptic expression level of glutamate receptors is a critical factor in determining the efficiency of information transmission and the activity of the neuronal network.

19 Nov 2018

New solution to stop spread of brain cancer

The tissues in our bodies largely are made of fluid. It moves around cells and is essential to normal body function.

19 Nov 2018

Researchers identify molecule to fight myotubular myopathy

Myotubular myopathy is a severe genetic disease that leads to muscle paralysis from birth and results in death before two years of age. Although no treatment currently exists, researchers from the University of Geneva, Switzerland, - working in collaboration with the University of Strasbourg, France, - have identified a molecule that not only greatly reduces the progression of the disease but also boosts life expectancy in animal models by a factor of seven.

19 Nov 2018

Molecular DNA analysis could facilitate more accurate prognosis, treatment of aggressive brain tumors

Meningiomas, a type of brain tumor, are usually easy to treat. However, there are a few subtypes that follow a very aggressive course and have high recurrence rates, i.e. there is a high risk of them coming back after treatment.

19 Nov 2018

Researchers develop novel mouse model to study immunomodulatory therapies

Because mice do not respond to immunomodulatory drugs, preclinical therapeutic and safety studies of the effects of IMiDs have not been possible in existing types of mice.

19 Nov 2018

New blood test developed for early diagnosis of ovarian cancer

Research on a bacterial toxin first discovered in Adelaide has led to the development a new blood test for the early diagnosis of ovarian cancer - a disease which kills over 1000 Australian women and 150,000 globally each year.

19 Nov 2018

Scientists equip new virus that kills carcinoma cells with protein

Scientists have equipped a virus that kills carcinoma cells with a protein so it can also target and kill adjacent cells that are tricked into shielding the cancer from the immune system.

19 Nov 2018

Experts debate over whether gut or brain is more important in regulating appetite

Whether gut or brain hormones are more important for the regulation of appetite and metabolism is not clearly defined. Imbalances in the control of appetite and metabolism can lead to obesity and diabetes, which have a negative impact on people's health and healthcare costs.

19 Nov 2018

New method studies how newborn baby's brain responds to being touched on face

A newborn baby's brain responds to being touched on the face, according to new research co-led by UCL.

19 Nov 2018

Human drugs alter cricket personality

Crickets that are exposed to human drugs that alter serotonin levels in the brain are less active and less aggressive than crickets that have had no drug exposure, according to a new study led by researchers from Linköping University. The findings have been published in Scientific Reports.

18 Nov 2018

Scientists discover new inhibitor that decreases lung inflammation

Scientists from the University of Sheffield have discovered a new inhibitor which decreases lung inflammation and could hold the key to treating Acute Respiratory Distress Syndrome - a life-threatening disease which affects thousands of people in the UK.

18 Nov 2018

New strategy to hinder emergence of antimicrobial-resistant pathogens

With many disease-causing bacteria ratcheting up their shields against current drugs, new tactics are vital to protect people from treatment-resistant infections.

17 Nov 2018

Reducing cellular proliferation could help deplete HIV reservoir and lead to a functional cure

A majority of the HIV-infected cells that persist in HIV-infected individuals even during suppressive antiretroviral therapy originated from cellular proliferation, not viral replication, according to new research published in Nature Communications.

17 Nov 2018

New model of FSHD could be useful to study effectiveness of experimental therapeutics

Facioscapulohumeral muscular dystrophy is the most prevalent dominantly inherited muscular dystrophy in the world. To date, there are no pharmacologic treatments available for the more than 850,000 people affected worldwide.

17 Nov 2018

UCLA biologists uncover how head injuries can lead to serious brain disorders

UCLA biologists have discovered how head injuries adversely affect individual cells and genes that can lead to serious brain disorders.

17 Nov 2018

Gene editing could be used to halt kidney disease in patients with Joubert syndrome

For the first time scientists have identified how to halt kidney disease in a life-limiting genetic condition, which may pave the way for personalized treatment in the future.

16 Nov 2018

Researchers identify LZTR1 as evolutionarily conserved component of RAS pathway

Mutations in RAS proteins initiate many of the most aggressive tumors, and the search for pharmacological inhibitors of these proteins has become a priority in the battle against cancer. Michail Steklov, Francesca Baietti, and colleagues from the Anna Sablina lab identified LZTR1 as an evolutionarily conserved component of the RAS pathway.

16 Nov 2018

Mechanisms that govern HIV latency differ in the gut and blood, finds study

Mechanisms that govern HIV transcription and latency differ in the gut and blood, according to a study published November 15 in the open-access journal PLOS Pathogens by Steven Yukl of San Francisco Veterans Affairs Medical Center and the University of California, San Francisco, and colleagues.

16 Nov 2018

Researchers find metabolite shuttle between cells in the liver that may combat tissue fibrosis

University of Minnesota Medical School researchers have made a discovery which could lead to a new way of thinking about how disease pathogenesis in the liver is regulated, which is important for understanding the condition nonalcoholic fatty liver disease, which is incredibly common and growing.

16 Nov 2018

Person's sex hormones may play key role in trauma survival, finds study

A person's sex hormones may play a role in trauma survival, according to a Kansas State University researcher who has received a $650,000 grant from the U.S. Department of Defense.

16 Nov 2018