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Research shows how recreational ketamine abuse harms the bladder

Research conducted by scientists at the University of York has revealed how recreational ketamine abuse damages the bladder

21 Mar 2016

Mutated gene GT198 has strong potential in early diagnosis of breast cancer

When mutated, a gene known for its ability to repair DNA, appears to instead cause breast cancer, scientists report.

21 Mar 2016

Ovarian serous cancer patients with overexpression of HER4 protein less likely respond to chemotherapy

Moffitt Cancer Center researchers discovered that patients with ovarian serous cancer and an overexpression of the HER4 protein are less likely to respond to chemotherapy and have a lower rate of survival.

21 Mar 2016

Scientists discover neural pathway that induces forgetting by actively erasing memories

They say that once you've learned to ride a bicycle, you never forget how to do it. But new research suggests that while learning, the brain is actively trying to forget. The study, by scientists at EMBL and University Pablo Olavide in Sevilla, Spain, is published today in Nature Communications

21 Mar 2016

MRX-2843 treatment improves survival of acute myeloid leukemia patients

Acute myeloid leukemia (AML) is a cancer of myeloid stem cells that develops in both adult and pediatric populations. Mutations that cause hyperactivation of the FMS-like tyrosine kinase 3 (FLT3) are commonly found in AML, and several clinical trials are testing FLT3 inhibitors.

21 Mar 2016

Trimeprazine improves β cell function, slows progression of diabetes

β cells in pancreatic islets are responsible for producing insulin, which is essential to regulate blood glucose homeostasis. In type 1 diabetes, pancreatic β cells are destroyed due to an autoimmune attack, whereas in type 2 diabetes, pancreatic β cells may have deficiencies in secreting insulin or insulin-responding tissues can become insulin resistant.

21 Mar 2016

New study provides insight into HIV-dependent immune dysfunction

HIV infection results in a variety of immune abnormalities, which are especially pronounced in individuals with high viral titers. B cells are the antibody producing cells of the immune system and are not directly infected by HIV.

21 Mar 2016

Researchers reveal link between necrotizing enterocolitis and uropathogenic E. coli

Necrotizing enterocolitis is an intestinal disease that afflicts about one in 10 extremely premature infants and is fatal in nearly one-third of cases. The premature infant gut is believed to react to colonizing bacteria, causing damage to the intestinal walls and severe infection.

21 Mar 2016

New ultra-sensitive technique shows promise as diagnostic tool for cancers, HIV

A common theme in medicine is that detecting a disease early on can lead to more effective treatments. This relies partly on luck that the patient gets screened at the right time, but more important is that the testing techniques are sensitive enough to register the minuscule hints that diseases leave in the blood stream.

21 Mar 2016

Women's stress hormone levels before pregnancy may predict lower-birthweight baby

Before women even become pregnant, their biological profile may predict a lower-birthweight baby, a UCLA-led research team reports.

21 Mar 2016

Six1 gene may have more substantial role in human kidney development

The best laid plans of mice and men are a bit different -- at least when it comes to kidney development. Compared to a mouse, a human has nearly 100 times more nephrons, the functional units of the kidneys. Humans may owe these abundant nephrons to a gene called SIX1, according to a new paper published in the journal Development.

21 Mar 2016

Study points to potential way to make people behave in less selfish, more altruistic ways

It's an age-old quandary: Are we born "noble savages" whose best intentions are corrupted by civilization, as the 18th century Swiss philosopher Jean-Jacques Rousseau contended? Or are we fundamentally selfish brutes who need civilization to rein in our base impulses, as the 17th century English philosopher Thomas Hobbes argued? After exploring the areas of the brain that fuel our empathetic impulses -- and temporarily disabling other regions that oppose those impulses -- two UCLA neuroscientists are coming down on the optimistic side of human nature.

21 Mar 2016

PERK inhibition can be a promising therapeutic strategy for neurodegenerative diseases

A major challenge in the field of neurodegeneration is the unclear understanding of neuronal dysfunction. Elucidation of these patho-mechanisms could result in the identification of novel therapeutic targets. In this article, Bell et al. present an exhaustive literature review highlighting the endoplasmic reticulum (ER) kinase PERK as a crucial contributor to systemic and neurodegenerative disorders.

20 Mar 2016

New type of nerve cells appears to control feeding behaviors in mice

While researching the brain's learning and memory system, scientists at Johns Hopkins say they stumbled upon a new type of nerve cell that seems to control feeding behaviors in mice. The finding, they report, adds significant detail to the way brains tell animals when to stop eating and, if confirmed in humans, could lead to new tools for fighting obesity. Details of the study will be published by the journal Science on March 18.

20 Mar 2016

Innovative treatment may help prevent brain swelling, death in stroke patients

New research has provided more evidence that an innovative treatment strategy may help prevent brain swelling and death in stroke patients. J. Marc Simard, professor of neurosurgery at the University of Maryland School of Medicine, along with colleagues at Yale University and Massachusetts General Hospital, found that Cirara, an investigational drug, powerfully reduced brain swelling and death in patients who had suffered a type of large stroke called malignant infarction, which normally carries a high mortality rate.

19 Mar 2016

UCMR researchers discover compounds that can attenuate virulence of Listeria monocytogenes

Scientists at Umea Centre for Microbial Research have discovered chemical compounds which are able to attenuate the virulence of the bacterial human pathogen Listeria monocytogenes. Their findings are published today in the high impact journal Cell Chemical Biology.

19 Mar 2016

Novel plasmid-based microRNA inhibitor system effectively prevents microRNA activity in cells

Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Brad Amendt, University of Iowa, Iowa City, USA, will present a study titled "New Biotechnology to Inhibit MicroRNA Activity and Novel Applications for Craniofacial and Dental Research."

19 Mar 2016

Rare ADCY9 mutations linked to non-syndromic oral clefts in Puerto Ricans

Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Carmen Buxó-Martínez, University of Puerto Rico, San Juan, will present a study titled "Identification of Rare ADCY9 Mutations and Non-syndromic Oral Clefts in Puerto Ricans." The AADR Annual Meeting is being held in conjunction with the 40th Annual Meeting of the Canadian Association for Dental Research.

19 Mar 2016

Patients with schizophrenia demonstrate specific leftward asymmetry for globus pallidus volume

A Japanese research group found that patients with schizophrenia demonstrated a specific leftward volumetric asymmetry for the globus pallidus, one of the basal ganglia of the brain. The basal ganglia are involved in motivation and volition, the impairment of which may result in difficulties in social life. This finding is expected to help elucidate the underlying pathological mechanisms of schizophrenia. Moreover, it will be a step toward the development of therapeutic strategies for schizophrenia.

19 Mar 2016

Manipulation of NAD could lead to potential therapy for acute kidney injury

Approximately one out of five hospitalized adults and one out of three hospitalized children worldwide experience acute kidney injury, the sudden loss of kidney function. Many different factors, including surgery, chemotherapy or shock, can lead to acute kidney injury, but exactly why the kidneys are so vulnerable to these and other stressors has not been well understood.

19 Mar 2016

Medical Science News

Research shows how recreational ketamine abuse harms the bladder

Mutated gene GT198 has strong potential in early diagnosis of breast cancer

Ovarian serous cancer patients with overexpression of HER4 protein less likely respond to chemotherapy

Scientists discover neural pathway that induces forgetting by actively erasing memories

MRX-2843 treatment improves survival of acute myeloid leukemia patients

Trimeprazine improves β cell function, slows progression of diabetes

New study provides insight into HIV-dependent immune dysfunction

Researchers reveal link between necrotizing enterocolitis and uropathogenic E. coli

New ultra-sensitive technique shows promise as diagnostic tool for cancers, HIV

Women's stress hormone levels before pregnancy may predict lower-birthweight baby

Six1 gene may have more substantial role in human kidney development

Study points to potential way to make people behave in less selfish, more altruistic ways

PERK inhibition can be a promising therapeutic strategy for neurodegenerative diseases

New type of nerve cells appears to control feeding behaviors in mice

Innovative treatment may help prevent brain swelling, death in stroke patients

UCMR researchers discover compounds that can attenuate virulence of Listeria monocytogenes

Novel plasmid-based microRNA inhibitor system effectively prevents microRNA activity in cells

Rare ADCY9 mutations linked to non-syndromic oral clefts in Puerto Ricans

Patients with schizophrenia demonstrate specific leftward asymmetry for globus pallidus volume

Manipulation of NAD could lead to potential therapy for acute kidney injury

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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