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BIDMC investigators identify precise 5-gene classifier for discriminating early pancreatic cancer

Pancreatic cancer, the fourth leading cause of cancer death in the United States, is often diagnosed at a late stage, when curative treatment is no longer possible. A team led by investigators at Beth Israel Deaconess Medical Center has now identified and validated an accurate 5-gene classifier for discriminating early pancreatic cancer from non-malignant tissue.

28 Mar 2016

Researchers demonstrate novel method for imaging engineered nanoparticles in tissues

As a testament to Governor Andrew Cuomo’s leadership in developing an unparalleled research and development ecosystem in New York State, Sara Brenner, MD, MPH and her colleagues at SUNY Polytechnic Institute (SUNY Poly), the George Washington School of Medicine and Health Sciences, and Stony Brook University have demonstrated a novel method for the rapid visualization and identification of engineered nanoparticles in tissues.

28 Mar 2016

Engineered HIV vaccine protein may prevent HIV infection

Some people infected with HIV naturally produce antibodies that effectively neutralize many strains of the rapidly mutating virus, and scientists are working to develop a vaccine capable of inducing such "broadly neutralizing" antibodies that can prevent HIV infection.

28 Mar 2016

Transient contractions could be new target for therapeutic intervention in urinary bladder dysfunction

Researchers at the University of Vermont College of Medicine have made a discovery that helps explain how we know when to empty our bladders and may lead to new therapeutic interventions for bladder dysfunction.

28 Mar 2016

Study reveals new hypothesis on evolution of hundreds of malaria species

A study published this week in the journal Molecular Phylogenetics and Evolution reveals a new hypothesis on the evolution of hundreds of species of malaria - including the form that is deadly to humans.

26 Mar 2016

Study identifies genetic differences in kidney tumors of African-Americans

A University of North Carolina Lineberger Comprehensive Cancer Center-led study has identified genetic differences in tumors of African-Americans with the most common type of kidney cancer compared with whites.

26 Mar 2016

MGH study finds that the brains of young marijuana users react differently to social exclusion

A study from Massachusetts General Hospital researchers finds that the brains of young adult marijuana users react differently to social exclusion than do those of non-users. In a report published in the March issue of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, the team reports that activation of the insula, a region of the brain that is usually active during social rejection, was reduced in young marijuana users when they were being excluded from participation in virtual game of catch.

26 Mar 2016

UC Berkeley biologists discover potential target for unisex contraceptives

UC Berkeley biologists have discovered the switch that triggers the power kick sperm use to penetrate and fertilize a human egg, uncovering a possible source of male infertility but also a potential target for contraceptives that work in both men and women.

26 Mar 2016

Changing one atom in InsP6 inhibitor can increase its ability to neutralize toxins in the gut

Infections with bacterium Clostridium difficile have rapidly become a significant medical problem in hospitals and long-term care facilities. The bacteria cause diarrhea and life-threatening inflammation of the colon by producing toxins that kill the endothelial cells that form the lining of the gut.

26 Mar 2016

Inactivation of protein-coding gene promotes liver tissue regeneration in mammals

Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) report that inactivating a certain protein-coding gene promotes liver tissue regeneration in mammals.

26 Mar 2016

Study demonstrates possibility of simultaneous improvement in all mental, physical functions

Let's say you've decided to make some changes in your life. You're out of shape, your mind wanders, your self-esteem is wavering, and you have no idea what you just read. So you decide to focus on one thing -- losing weight, maybe -- and tackle the other issues later. You don't want to take on too much at once, right?

26 Mar 2016

Researchers develop rapid yet inexpensive test for TB

Although tuberculosis (TB) is commonly thought of as being a disease that mainly affects nineteenth century poets and Victor Hugo characters, it is still the second-most common cause of mortality from an infectious disease in the world, killing nearly three people every minute. Every March 24, on World TB Day, the global health community recognizes the work of Robert Koch, who announced on that date in 1882 his discovery of Mycobacterium tuberculosis, the bacteria that causes TB.

25 Mar 2016

Neuroscientists decipher new pathway in stem cell differentiation

How do neurons become neurons? They all begin as stem cells, undifferentiated and with the potential to become any cell in the body.Until now, however, exactly how that happens has been somewhat of a scientific mystery. New research conducted by UC Santa Barbara neuroscientists has deciphered some of the earliest changes that occur before stems cells transform into neurons and other cell types.

25 Mar 2016

DNA sequence features predict genome-wide binding pattern of key protein involved in brain disorders

Researchers from the University of Illinois at Urbana-Champaign and the University of California-Davis are combining in vivo experimentation with computation for highly accurate prediction of the genome-wide binding pattern of a key protein involved in brain disorders.

25 Mar 2016

Wnt secretion inhibitors may reduce renal fibrosis

Renal fibrosis or the scarring of kidneys, following an injury, reduces their function and can cause kidney disease to progressively worsen.

25 Mar 2016

Findings could help explain origin of type 2 diabetes in children of obese mothers

A new study led by researchers at The Saban Research Institute of Children's Hospital Los Angeles reports that the presence of leptin - a hormone secreted by fat cells that is critical to maintaining energy balance in the body -- inhibits the prenatal development of neuronal connections between the brain and pancreas. The findings could help explain the origin of type 2 diabetes, particularly in children of obese mothers.

25 Mar 2016

Self-repairing cancer cells: A new pathway for cancer treatment

With narrow bodies and no collarbones, mice are able to squeeze through holes as small as a quarter-inch in diameter. Cancer cells similarly are able to migrate through extremely tight quarters but with a major difference: The journey often comes at a price - the deformation and, in some cases, rupture of the outer lining of a cell's nucleus. While deformation and rupture can sometimes lead to cell death, the cell - about 90 percent of the time - also has the ability to repair itself.

25 Mar 2016

Penn chemists find potential ways to use methane in pharmaceuticals, value-added substances

Methane is the world's most abundant hydrocarbon. It's the major component of natural gas and shale gas and, when burned, is an effective fuel. But it's also a major contributor to climate change, with 24 times greater potency as a greenhouse gas than carbon dioxide.

25 Mar 2016

Lack of UBE3A gene causes Angelman syndrome

The gene UBE3A plays a critical role in early neurological development. If UBE3A is overexpressed - or if the enzymatic function of UBE3A protein is hyperactive - autism ensues. A lack of functional UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder characterized by severe developmental delay, motor deficits, absence of speech, and, in most cases, epilepsy.

25 Mar 2016

Common genetic defect in beta cells may underlie both known forms of diabetes

New research by Dr. Sylvie Lesage, scientist at Maisonneuve-Rosemont Hospital and associate research Professor at University of Montreal, just published in the prestigious international scientific journal Nature Genetics, has discovered that a common genetic defect in beta cells may underlie both known forms of diabetes.

25 Mar 2016

Medical Science News

BIDMC investigators identify precise 5-gene classifier for discriminating early pancreatic cancer

Researchers demonstrate novel method for imaging engineered nanoparticles in tissues

Engineered HIV vaccine protein may prevent HIV infection

Transient contractions could be new target for therapeutic intervention in urinary bladder dysfunction

Study reveals new hypothesis on evolution of hundreds of malaria species

Study identifies genetic differences in kidney tumors of African-Americans

MGH study finds that the brains of young marijuana users react differently to social exclusion

UC Berkeley biologists discover potential target for unisex contraceptives

Changing one atom in InsP6 inhibitor can increase its ability to neutralize toxins in the gut

Inactivation of protein-coding gene promotes liver tissue regeneration in mammals

Study demonstrates possibility of simultaneous improvement in all mental, physical functions

Researchers develop rapid yet inexpensive test for TB

Neuroscientists decipher new pathway in stem cell differentiation

DNA sequence features predict genome-wide binding pattern of key protein involved in brain disorders

Wnt secretion inhibitors may reduce renal fibrosis

Findings could help explain origin of type 2 diabetes in children of obese mothers

Self-repairing cancer cells: A new pathway for cancer treatment

Penn chemists find potential ways to use methane in pharmaceuticals, value-added substances

Lack of UBE3A gene causes Angelman syndrome

Common genetic defect in beta cells may underlie both known forms of diabetes

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

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