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Advanced genomic sequencing tracks deadly blood infection in cancer patients

The Translational Genomics Research Institute, working with international investigators, have discovered the source of a potential deadly blood infection in more than 50 South American cancer patients.

21 Mar 2016

KORs could be potential drug target for treatment of addiction, anxiety disorders

University of North Carolina researchers uncovered a cellular mechanism by which kappa opioid receptors (KOR) drive anxiety. These proteins inhibit the release of the neurotransmitter glutamate in a part of the brain that regulates emotion.

21 Mar 2016

OGT launches new CytoSure Constitutional v3 +LOH array for genetic analysis of developmental disorders

Oxford Gene Technology, The Molecular Genetics Company, has announced the launch of its new CytoSure Constitutional v3 +LOH array for comprehensive genetic analysis of developmental delay disorders.

From Oxford Gene Technology 21 Mar 2016

Study shows aging affects adaptive immune responses

Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Jeffrey Ebersole, University of Kentucky, Lexington, USA, will present a study titled "Systemic Antibody Responses to Oral Bacteria with Aging." The AADR Annual Meeting is being held in conjunction with the 40th Annual Meeting of the Canadian Association for Dental Research.

21 Mar 2016

Combined loss of XPO1, BCL11A and REL linked to 2p15p16.1 microdeletion syndrome

Individuals with 2p15p16.1 microdeletion syndrome present with intellectual disability, microcephaly, delayed growth, dysmorphic craniofacial features, and digital abnormalities.

21 Mar 2016

Aging-associated changes begin earlier than expected in human brain

A new study published in Physiological Genomics suggests that the brain shows signs of aging earlier than old age. The study found that the microglia cells—the immune cells of the brain—in middle-aged mice already showed altered activity seen in microglia from older mice.

21 Mar 2016

New molecular probe can detect different amyloid deposits in human tissues

A team of scientists at Sweden's Linköping University have developed a molecular probe that can detect an array of different amyloid deposits in several human tissues. This new probe is extremely sensitive and was used at very low concentrations to correctly identify every positive amyloidosis sample when compared to the traditional clinical tests.

21 Mar 2016

IUPUI investigators use stem cells to identify potential therapies to prevent glaucoma

Using stem cells derived from human skin cells, researchers led by Jason Meyer, assistant professor of biology, along with graduate student Sarah Ohlemacher of the School of Science at Indiana University-Purdue University Indianapolis, have successfully demonstrated the ability to turn stem cells into retinal ganglion cells (RGCs), the neurons that conduct visual information from the eye to the brain.

21 Mar 2016

Researchers describe generation of plasma cell-specific antibody from immunized lampreys

Antibody-secreting plasma cells arise from B cell precursors and are essential for adaptive immune responses against invading pathogens. Plasma cell dysfunction is associated with autoimmune and neoplastic disorders, including multiple myeloma.

21 Mar 2016

Researchers elucidate mechanisms underlying impaired ciliogenesis in PKD

In an article published online ahead of print on Feb. 19, 2015 in the Journal of Biological Chemistry, investigators at the Medical University of South Carolina and the Ralph H. Johnson VA Medical Center report findings from in vitro and in vivo studies that elucidate the mechanisms underlying the impaired ciliogenesis and abnormal kidney development characteristic of polycystic kidney disease (PKD).

21 Mar 2016

Educating citizen scientists can boost integrity of scientific research

Maria Barraza has been a Community Health Worker for 25 years, providing health services and facilitating research studies in underserved areas where disparities are most prevalent. In her role, Barraza contributes to the development and implementation of community and clinic-based research studies

21 Mar 2016

Research shows how recreational ketamine abuse harms the bladder

Research conducted by scientists at the University of York has revealed how recreational ketamine abuse damages the bladder

21 Mar 2016

Mutated gene GT198 has strong potential in early diagnosis of breast cancer

When mutated, a gene known for its ability to repair DNA, appears to instead cause breast cancer, scientists report.

21 Mar 2016

Ovarian serous cancer patients with overexpression of HER4 protein less likely respond to chemotherapy

Moffitt Cancer Center researchers discovered that patients with ovarian serous cancer and an overexpression of the HER4 protein are less likely to respond to chemotherapy and have a lower rate of survival.

21 Mar 2016

Scientists discover neural pathway that induces forgetting by actively erasing memories

They say that once you've learned to ride a bicycle, you never forget how to do it. But new research suggests that while learning, the brain is actively trying to forget. The study, by scientists at EMBL and University Pablo Olavide in Sevilla, Spain, is published today in Nature Communications

21 Mar 2016

MRX-2843 treatment improves survival of acute myeloid leukemia patients

Acute myeloid leukemia (AML) is a cancer of myeloid stem cells that develops in both adult and pediatric populations. Mutations that cause hyperactivation of the FMS-like tyrosine kinase 3 (FLT3) are commonly found in AML, and several clinical trials are testing FLT3 inhibitors.

21 Mar 2016

Trimeprazine improves β cell function, slows progression of diabetes

β cells in pancreatic islets are responsible for producing insulin, which is essential to regulate blood glucose homeostasis. In type 1 diabetes, pancreatic β cells are destroyed due to an autoimmune attack, whereas in type 2 diabetes, pancreatic β cells may have deficiencies in secreting insulin or insulin-responding tissues can become insulin resistant.

21 Mar 2016

New study provides insight into HIV-dependent immune dysfunction

HIV infection results in a variety of immune abnormalities, which are especially pronounced in individuals with high viral titers. B cells are the antibody producing cells of the immune system and are not directly infected by HIV.

21 Mar 2016

Researchers reveal link between necrotizing enterocolitis and uropathogenic E. coli

Necrotizing enterocolitis is an intestinal disease that afflicts about one in 10 extremely premature infants and is fatal in nearly one-third of cases. The premature infant gut is believed to react to colonizing bacteria, causing damage to the intestinal walls and severe infection.

21 Mar 2016

New ultra-sensitive technique shows promise as diagnostic tool for cancers, HIV

A common theme in medicine is that detecting a disease early on can lead to more effective treatments. This relies partly on luck that the patient gets screened at the right time, but more important is that the testing techniques are sensitive enough to register the minuscule hints that diseases leave in the blood stream.

21 Mar 2016

Medical Science News

Advanced genomic sequencing tracks deadly blood infection in cancer patients

KORs could be potential drug target for treatment of addiction, anxiety disorders

OGT launches new CytoSure Constitutional v3 +LOH array for genetic analysis of developmental disorders

Study shows aging affects adaptive immune responses

Combined loss of XPO1, BCL11A and REL linked to 2p15p16.1 microdeletion syndrome

Aging-associated changes begin earlier than expected in human brain

New molecular probe can detect different amyloid deposits in human tissues

IUPUI investigators use stem cells to identify potential therapies to prevent glaucoma

Researchers describe generation of plasma cell-specific antibody from immunized lampreys

Researchers elucidate mechanisms underlying impaired ciliogenesis in PKD

Educating citizen scientists can boost integrity of scientific research

Research shows how recreational ketamine abuse harms the bladder

Mutated gene GT198 has strong potential in early diagnosis of breast cancer

Ovarian serous cancer patients with overexpression of HER4 protein less likely respond to chemotherapy

Scientists discover neural pathway that induces forgetting by actively erasing memories

MRX-2843 treatment improves survival of acute myeloid leukemia patients

Trimeprazine improves β cell function, slows progression of diabetes

New study provides insight into HIV-dependent immune dysfunction

Researchers reveal link between necrotizing enterocolitis and uropathogenic E. coli

New ultra-sensitive technique shows promise as diagnostic tool for cancers, HIV

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

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