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Salk Institute to establish Helmsley Center for Genomic Medicine

The Salk Institute for Biological Studies has received a $42 million gift-the largest in the Institute's history-to establish the Helmsley Center for Genomic Medicine (HCGM), a research center dedicated to decoding the common genetic factors underlying many complex chronic human diseases.

23 Jan 2013

Data from Provectus' PV-10 pre-clinical study on melanoma to be presented at AACR meeting

Provectus Pharmaceuticals, Inc., a development-stage oncology and dermatology biopharmaceutical company, announces that data on PV-10 will be presented in a poster presentation at the American Association for Cancer Research Annual Meeting in Washington, DC.

23 Jan 2013

Researchers pinpoint several inherited mutations in autism

While autism clearly runs in some families, few inherited genetic causes have been found. A major reason is that these causes are so varied that it's hard to find enough people with a given mutation to establish a clear pattern. Researchers at Boston Children's Hospital have pinpointed several inherited mutations—among the first to be identified—through an unusual approach: using whole-exome sequencing to study large Middle Eastern families with autism.

23 Jan 2013

Enterococcal cytolysin synthetase helps form distinctly different, 3-D protein ring structures

While working out the structure of a cell-killing protein produced by some strains of the bacterium Enterococcus faecalis, researchers stumbled on a bit of unusual biochemistry. They found that a single enzyme helps form distinctly different, three-dimensional ring structures in the protein, one of which had never been observed before.

23 Jan 2013

Strong link between mortality and reduced innate immune responsiveness in critically ill patients

Investigators from 15 children's medical centers, including Nationwide Children's Hospital, observed and evaluated critically ill children with influenza to evaluate the relationships between levels of systemic inflammation, immune function and likelihood to die from the illness. The study appears in the January issue of Critical Care Medicine.

23 Jan 2013

SMO and AKT1 mutations appear to drive about 15% of meningiomas

Large-scale genomic sequencing has revealed two DNA mutations that appear to drive about 15 percent of brain tumors known as meningiomas, a finding that could lead to the first effective drug treatments for the tumors, report scientists from Dana-Farber Cancer Institute and the Broad Institute.

23 Jan 2013

AANS, CNS join other medical societies in endorsing Protecting Seniors' Access to Medicare Act

The American Association of Neurological Surgeons (AANS) and Congress of Neurological Surgeons (CNS) joined 24 other medical societies in endorsing the "Protecting Seniors' Access to Medicare Act." Sponsored by Reps. Phil Roe, MD (R-TN) and Allyson Schwartz (D-PA), this bipartisan legislation would repeal the Independent Payment Advisory Board (IPAB), thereby protecting seniors from Medicare cuts that could threaten their access to care.

23 Jan 2013

New targeted enzyme replacement therapy can treat X-linked myotubular myopathy

A collaborative research team including a Medical College of Wisconsin (MCW) pediatric neuropathologist successfully mitigated some of the effects of a muscular disease by using a new targeted enzyme replacement therapy strategy from 4s3 Bioscience.

23 Jan 2013

Gene therapy does not slow or halt progression of cell loss in Leber congenital amaurosis

Independent clinical trials, including one conducted at the Scheie Eye Institute at the Perelman School of Medicine, have reported safety and efficacy for Leber congenital amaurosis (LCA), a congenital form of blindness caused by mutations in a gene (RPE65) required for recycling vitamin A in the retina. Inherited retinal degenerative diseases were previously considered untreatable and incurable.

23 Jan 2013

Exposure of human f-tal testicles to bisphenol A reduces testosterone production

Bisphenol A (BPA) is a chemical compound that is included in the composition of plastics and resins. It is used, for example, in the manufacture of food containers such as bottles and babies' feeding bottles. It is also found in the protective films used inside food and drink cans and on till receipts where it used as a discloser. Significant levels of BPA have also been found in human blood, urine, amniotic fluid and placentas.

23 Jan 2013

GeneDiagnostics, WILEX partner to commercialize serum HER-2/neu ELISA test in China

WILEX AG today announced that its US subsidiary WILEX Inc., Cambridge, MA, has entered into an exclusive distribution agreement with GeneDiagnostics Inc. for the commercialization of the serum HER-2/neu ELISA test in China.

23 Jan 2013

CD98hc molecule appears to be necessary for rapid and effective skin renewal

These mechanisms, described in vivo in mice, engage molecule CD98hc, which is involved in epidermis renewal and could be an indicator of the skin's capacity for regeneration.

23 Jan 2013

UCLA researchers identify abnormal tau proteins associated with sports-related concussions

Sports-related concussions and mild traumatic brain injuries have grabbed headlines in recent months, as the long-term damage they can cause becomes increasingly evident among both current and former athletes. The Centers for Disease Control and Prevention estimates that millions of these injuries occur each year.

23 Jan 2013

Study details exactly how Her2 gene promotes progression and spread of breast cancer cells

Research led by Dr. Suresh Alahari, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and its Stanley S. Scott Cancer Center, details exactly how the Her2 cancer gene promotes the progression and spread of breast cancer cells.

23 Jan 2013

Keeping healthy blood cells alive could help fight leukaemia

Instead of focusing on the elimination of cancer cells, maintaining a stable population of healthy blood cells in the bone marrow could be the most effective way to fight against leukaemia.

23 Jan 2013

Novel way to engineer specialized immune cells targeted by the AIDS virus

Researchers at the Stanford University School of Medicine have found a novel way to engineer key cells of the immune system so they remain resistant to infection with HIV, the virus that causes AIDS.

23 Jan 2013

EBV reactivation can increase risk of heart disease

A new study could provide the link that scientists have been looking for to confirm that reactivation of a latent herpes virus is a cause of some heart problems.

23 Jan 2013

Studies identify cellular pathways involved in governing day-night pattern of circadian rhythms

UC Irvine-led studies have revealed the cellular mechanism by which circadian rhythms - also known as the body clock - modify energy metabolism and also have identified novel compounds that control this action. The findings point to potential treatments for disorders triggered by circadian rhythm dysfunction, ranging from insomnia and obesity to diabetes and cancer.

23 Jan 2013

Galectin Therapeutics' GR-MD-02 reverses diabetic nephropathy in preclinical study

Galectin Therapeutics, the leading developer of therapeutics that target galectin proteins to treat fibrosis and cancer, today announced new preclinical data on the efficacy of anti-galectin therapy on diabetic kidney disease.

23 Jan 2013

Research on dystrophin gene sequence could lead to treatments for Duchenne muscular dystrophy

Muscular dystrophy is caused by the largest human gene, a complex chemical leviathan that has confounded scientists for decades. Research conducted at the University of Missouri and described this month in the Proceedings of the National Academy of Sciences has identified significant sections of the gene that could provide hope to young patients and families.

23 Jan 2013

Medical Science News

Salk Institute to establish Helmsley Center for Genomic Medicine

Data from Provectus' PV-10 pre-clinical study on melanoma to be presented at AACR meeting

Researchers pinpoint several inherited mutations in autism

Enterococcal cytolysin synthetase helps form distinctly different, 3-D protein ring structures

Strong link between mortality and reduced innate immune responsiveness in critically ill patients

SMO and AKT1 mutations appear to drive about 15% of meningiomas

AANS, CNS join other medical societies in endorsing Protecting Seniors' Access to Medicare Act

New targeted enzyme replacement therapy can treat X-linked myotubular myopathy

Gene therapy does not slow or halt progression of cell loss in Leber congenital amaurosis

Exposure of human f-tal testicles to bisphenol A reduces testosterone production

GeneDiagnostics, WILEX partner to commercialize serum HER-2/neu ELISA test in China

CD98hc molecule appears to be necessary for rapid and effective skin renewal

UCLA researchers identify abnormal tau proteins associated with sports-related concussions

Study details exactly how Her2 gene promotes progression and spread of breast cancer cells

Keeping healthy blood cells alive could help fight leukaemia

Novel way to engineer specialized immune cells targeted by the AIDS virus

EBV reactivation can increase risk of heart disease

Studies identify cellular pathways involved in governing day-night pattern of circadian rhythms

Galectin Therapeutics' GR-MD-02 reverses diabetic nephropathy in preclinical study

Research on dystrophin gene sequence could lead to treatments for Duchenne muscular dystrophy

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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