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Blocking cholesterol biosynthesis pathway in cancer cells appears to improve ability of common drugs

Shutting down a specific pathway in cancer cells appears to improve the ability of common drugs to wipe those cells out, according to new research from scientists at Fox Chase Cancer Center, published in the January issue of Cancer Discovery.

16 Jan 2013

Sp2 protein plays a key role in creation of neurons from stem cells

A protein known as Sp2 is key to the proper creation of neurons from stem cells, according to researchers at North Carolina State University. Understanding how this protein works could enable scientists to "program" stem cells for regeneration, which has implications for neural therapies.

16 Jan 2013

Fifteen established scientists to receive NARSAD Distinguished Investigator Grants

The Brain & Behavior Research Foundation (formerly NARSAD, the National Alliance for Research on Schizophrenia and Depression) announced the latest recipients of its highly competitive NARSAD Distinguished Investigator Grants.

16 Jan 2013

Researchers identify new group of growth factor receptors that signal to brain tumours

One in 25,000 people worldwide is affected by neurofibromatosis type 2 (NF2), a condition where the loss of a tumour suppressor called Merlin results in multiple tumours in the brain and nervous system.

16 Jan 2013

Speech entrainment benefits stroke victims with Broca's aphasia

Stroke victims affected with loss of speech caused by Broca's aphasia have been shown to speak fluidly through the use of a process called "speech entrainment" developed by researchers at the University of South Carolina's Arnold School of Public Health.

16 Jan 2013

Stem cell transplantation prevents decrease in heart function associated with DMD

Researchers have shown that transplanting stem cells derived from normal mouse blood vessels into the hearts of mice that model the pathology associated with Duchenne muscular dystrophy (DMD) prevents the decrease in heart function associated with DMD.

16 Jan 2013

MI-ONCOSEQ program identifies NAB2-STAT6 fusion in solitary fibrous tumors

It started with a 44-year-old woman with solitary fibrous tumor, a rare cancer seen in only a few hundred people each year. By looking at the entire DNA from this one patient's tumor, researchers have found a genetic anomaly that provides an important clue to improving how this cancer is diagnosed and treated.

16 Jan 2013

Research shows genetic factors increase risk of visceral leishmaniasis

A new study published in Nature Genetics last week shows that genetics likely influence whether an individual develops visceral leishmaniasis, a lethal form of the parasitic disease transmitted by sandflies, the New York Times reports.

16 Jan 2013

Jan. issue of Behavioural Neurology features papers on aphasia and hemispatial neglect

Approximately half a million individuals suffer strokes in the US each year, and about one in five develops some form of post-stroke aphasia, the partial or total loss of the ability to communicate. By comparing different types of aphasia, investigators have been able to gain new insights into the normal cognitive processes underlying language, as well as the potential response to interventions.

16 Jan 2013

Study identifies 24 new copy number variants linked with autism

University of Utah (the U) researchers, in collaboration with several groups from around the country, published a paper on Monday, Jan. 14, 2013, following one of the biggest studies of its kind, that extends our understanding of genes related to autism spectrum diseases (ASDs) and advances methods for early detection and treatment.

16 Jan 2013

Health, science and genetics reporters invited to register now for ACMG annual genetics meeting

Health, science and genetics reporters are invited to register now for the American College of Medical Genetics and Genomics (ACMG) Annual Clinical Genetics Meeting, March 19-23, 2013 at the Phoenix Convention Center.

16 Jan 2013

NEDD9 gene controls growth of progenitor cells that give rise to breast tumors

Breast cancer is the second leading cause of cancer deaths among women in the United States. Many of these deaths occur when there is an initial diagnosis of invasive or metastatic disease. A protein called NEDD9-which regulates cell migration, division and survival-has been linked to tumor invasion and metastasis in a variety of cancers.

16 Jan 2013

Experimental vaccine elicits antibodies that can protect against Ebola virus infection

Researchers at the National Institutes of Health (NIH) and Oregon Health & Science University (OHSU) have found that an experimental vaccine elicits antibodies that can protect nonhuman primates from Ebola virus infection.

16 Jan 2013

Patients with Parkinson's develop artistic talents after dopamine-inducing therapy

Parkinson's experts across the world have been reporting a remarkable phenomenon - many patients treated with drugs to increase the activity of dopamine in the brain as a therapy for motor symptoms such as tremors and muscle rigidity are developing new creative talents, including painting, sculpting, writing, and more.

16 Jan 2013

Genetics researchers identify 25 additional copy number variations associated with autism

Genetics researchers have identified 25 additional copy number variations (CNVs)—missing or duplicated stretches of DNA—that occur in some patients with autism. These CNVs, say the researchers, are "high impact": although individually rare, each has a strong effect in raising an individual's risk for autism.

16 Jan 2013

Study explains how Timothy syndrome mutation causes wiring defects that underlie cognition

A new finding in neuroscience for the first time points to a developmental mechanism linking the disease-causing mutation in an autism-related disorder, Timothy syndrome, and observed defects in brain wiring, according to a study led by scientist Ricardo Dolmetsch and published online yesterday in Nature Neuroscience.

16 Jan 2013

Link between smoking intensity and bladder cancer prognosis

Smoking not only causes bladder cancer-it also affects its course, in that people who smoke more have greater likelihood of developing more aggressive and deadly disease. That is one of the conclusions of a new study published early online in CANCER, a peer-reviewed journal of the American Cancer Society.

16 Jan 2013

Clathrin protein may have a role in suppressing tumors

Newly published research by Indiana University structural biologist Joel Ybe and colleagues identifies a "topology switch" in the protein clathrin, the function of which may shed light on molecular processes involved in tumor suppression.

16 Jan 2013

Thermo Fisher's expandable portfolio of lab automation solutions to be showcased at SLAS 2013

Thermo Fisher Scientific Inc., the world leader in serving science, today introduced a new range of laboratory automation and screening solutions during the Second Annual Society for Laboratory Automation and Screening (SLAS) conference and exhibition.

From Thermo Fisher Scientific Inc. 16 Jan 2013

Diospyrin inactivates a drug target for tuberculosis in new way

A compound from the South African toothbrush tree inactivates a drug target for tuberculosis in a previously unseen way.

16 Jan 2013

Medical Science News

Blocking cholesterol biosynthesis pathway in cancer cells appears to improve ability of common drugs

Sp2 protein plays a key role in creation of neurons from stem cells

Fifteen established scientists to receive NARSAD Distinguished Investigator Grants

Researchers identify new group of growth factor receptors that signal to brain tumours

Speech entrainment benefits stroke victims with Broca's aphasia

Stem cell transplantation prevents decrease in heart function associated with DMD

MI-ONCOSEQ program identifies NAB2-STAT6 fusion in solitary fibrous tumors

Research shows genetic factors increase risk of visceral leishmaniasis

Jan. issue of Behavioural Neurology features papers on aphasia and hemispatial neglect

Study identifies 24 new copy number variants linked with autism

Health, science and genetics reporters invited to register now for ACMG annual genetics meeting

NEDD9 gene controls growth of progenitor cells that give rise to breast tumors

Experimental vaccine elicits antibodies that can protect against Ebola virus infection

Patients with Parkinson's develop artistic talents after dopamine-inducing therapy

Genetics researchers identify 25 additional copy number variations associated with autism

Study explains how Timothy syndrome mutation causes wiring defects that underlie cognition

Link between smoking intensity and bladder cancer prognosis

Clathrin protein may have a role in suppressing tumors

Thermo Fisher's expandable portfolio of lab automation solutions to be showcased at SLAS 2013

Diospyrin inactivates a drug target for tuberculosis in new way

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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