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First demonstration of newly developed dual humanized FRGTM KO system against malaria

A novel human liver-chimeric mouse model developed at Oregon Health & Science University and Yecuris Corporation has made possible a research breakthrough at Seattle Biomedical Research Institute that will greatly accelerate studies of the most lethal forms of human malaria.

11 Sep 2012

KRAS gene mutation recruits second player to trigger pancreatic cancer

More than a cancer-causing gene is needed to trigger pancreatic cancer, a study led by Mayo Clinic has found. A second factor creates a "perfect storm" that allows tumors to form, the researchers say. The study, published in the Sept. 10 issue of Cancer Cell, overturns the current belief that a mutation in the KRAS oncogene is enough to initiate pancreatic cancer and unrestrained cell growth.

11 Sep 2012

Polysaccharopeptide improves survival in dogs with hemangiosarcoma

Dogs with hemangiosarcoma that were treated with a compound derived from the Coriolus versicolor mushroom had the longest survival times ever reported for dogs with the disease.

11 Sep 2012

U of I microbial engineer synthesizes 2-fucosyllactose to protect babies from pathogens

A University of Illinois microbial engineer has synthesized a sugar in human milk that is thought to protect babies from pathogens. That's important because 2FL, the shorthand scientists use to describe this human milk oligosaccharide (HMO), has not been added to infant formula because HMOs are incredibly expensive.

11 Sep 2012

MicroRNA-145 gene therapy can drastically reduce severity and progression of atherosclerosis

Researchers at St. Michael's Hospital are one step closer to understanding why plaque bursts in coronary arteries and causes heart attacks.

11 Sep 2012

Joslin Diabetes Center, Mass. Eye and Ear partner to form clinical and research alliance

Massachusetts Eye and Ear and the Joslin Diabetes Center announced today that they have reached agreement to form a clinical and research alliance, aimed toward providing coordinated high quality care to eye patients throughout greater Boston, especially those with or at-risk for diabetes-related eye disease.

11 Sep 2012

Yale University professor receives 2012 Vanderbilt Prize in Biomedical Science

The 2012 Vanderbilt Prize in Biomedical Science has been awarded to Yale University professor Joan Steitz, Ph.D., whose pioneering work has helped reveal and clarify the complexities of RNA and the roles that RNA molecules play in health and disease.

11 Sep 2012

Cardiac stem cells from newborns show stronger regenerative ability

Researchers at the University of Maryland School of Medicine, who are exploring novel ways to treat serious heart problems in children, have conducted the first direct comparison of the regenerative abilities of neonatal and adult-derived human cardiac stem cells.

11 Sep 2012

RNA researcher to receive 2012 Pearl Meister Greengard Prize from The Rockefeller University

Joan A. Steitz, Ph.D., a pioneer in the field of RNA biology whose discoveries involved patients with a variety of autoimmune diseases, will be awarded the 2012 Pearl Meister Greengard Prize from The Rockefeller University. The prize, which honors female scientists who have made extraordinary contributions to biomedical science and carries an honorarium of $100,000, will be presented at a ceremony on Thursday, November 29 at Rockefeller University's Caspary Auditorium.

11 Sep 2012

Rhode Island receives NIH grant to study cartilage and joint health

Rhode Island Hospital's Center of Biomedical Research Excellence (COBRE) in Skeletal Health and Repair has been awarded a $10.8 million grant from the National Institutes of Health (NIH), one of the largest grants in Rhode Island Hospital history. This grant, to be paid over five years, will fund studies of cartilage and joint health.

11 Sep 2012

Babies' ability to detect complex rules in language outshines that of adults

New research examining auditory mechanisms of language learning in babies has revealed that infants as young as three months of age are able to automatically detect and learn complex dependencies between syllables in spoken language.

11 Sep 2012

Study discovers pathways that govern instability of GAA/TTC repeats

A study of more than 6,000 genes in a common species of yeast has identified the pathways that govern the instability of GAA/TTC repeats. In humans, the expansions of these repeats is known to inactivate a gene - FXN - which leads to Friedreich's ataxia, a neurodegenerative disease that is currently incurable. In yeast, long repeats also destabilize the genome, manifested by the breakage of chromosomes.

11 Sep 2012

Researchers gain new insight into regulation of adult nerve cell generation in the hypothalamus

Researchers from the University of Utah have gained new insight into the regulation of adult nerve cell generation in the hypothalamus, the part of the brain that regulates many aspects of behavior, mood, and metabolism.

11 Sep 2012

P5091 molecule triggers apoptosis in drug-resistant myeloma cells

A molecule that targets the cell's machinery for breaking down unneeded proteins can kill multiple myeloma cancer cells resistant to the frontline drug Velcade, researchers at Dana-Farber Cancer Institute have found.

11 Sep 2012

Researchers discover small DNA sequence that drives GATA2 protein

The protein GATA2 is known as a "master regulator" of blood cell development. When a mutation occurs in the gene that makes GATA2, serious blood diseases such as acute myeloid leukemia can result.

11 Sep 2012

Two different genetic mutations cooperate to induce adrenal cancer

Two different genetic mutations cooperate to induce adrenal cancer, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center and University of Sao Paulo in Brazil.

11 Sep 2012

People with MCI are impaired in several aspects of executive functioning

By the time older adults are diagnosed with Alzheimer's disease, the brain damage is irreparable. For now, modern medicine is able to slow the progression of the disease but is incapable of reversing it. What if there was a way to detect if someone is on the path to Alzheimer's before substantial and non-reversible brain damage sets in?

11 Sep 2012

HIF-1 activity directly responsible for spread of breast cancer to lymph vessels

The invasion of cancer cells into the lymph vessels that connect the breast to surrounding lymph nodes is the first step leading to the metastasis, or spread, of cancer throughout the body. Metastasis is the primary cause of breast cancer deaths. Surprisingly little is known about the control of this process and how it might be interrupted to prolong the lives of women with breast cancer.

11 Sep 2012

Combining two drugs may offer new and potent punch against cancer and other diseases

A new study by researchers at Weill Cornell Medical College shows combining two already-FDA approved drugs may offer a new and potent punch against diseases in which blood vessel growth is abnormal -- such as cancer, diabetic retinopathy, macular degeneration and rheumatoid arthritis.

11 Sep 2012

Oxyphenbutazone can kill drug resistant TB

An off-patent anti-inflammatory drug that costs around two cents for a daily dose in developing countries has been found by researchers at Weill Cornell Medical College to kill both replicating and non-replicating drug resistant tuberculosis in the laboratory -- a feat few currently approved TB drugs can do, and resistance to those is spreading.

11 Sep 2012

Medical Science News

First demonstration of newly developed dual humanized FRGTM KO system against malaria

KRAS gene mutation recruits second player to trigger pancreatic cancer

Polysaccharopeptide improves survival in dogs with hemangiosarcoma

U of I microbial engineer synthesizes 2-fucosyllactose to protect babies from pathogens

MicroRNA-145 gene therapy can drastically reduce severity and progression of atherosclerosis

Joslin Diabetes Center, Mass. Eye and Ear partner to form clinical and research alliance

Yale University professor receives 2012 Vanderbilt Prize in Biomedical Science

Cardiac stem cells from newborns show stronger regenerative ability

RNA researcher to receive 2012 Pearl Meister Greengard Prize from The Rockefeller University

Rhode Island receives NIH grant to study cartilage and joint health

Babies' ability to detect complex rules in language outshines that of adults

Study discovers pathways that govern instability of GAA/TTC repeats

Researchers gain new insight into regulation of adult nerve cell generation in the hypothalamus

P5091 molecule triggers apoptosis in drug-resistant myeloma cells

Researchers discover small DNA sequence that drives GATA2 protein

Two different genetic mutations cooperate to induce adrenal cancer

People with MCI are impaired in several aspects of executive functioning

HIF-1 activity directly responsible for spread of breast cancer to lymph vessels

Combining two drugs may offer new and potent punch against cancer and other diseases

Oxyphenbutazone can kill drug resistant TB

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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