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Study suggests link between gene variant and Proteus syndrome

Orthopaedic surgeons from Children's National Medical Center are part of a team of researchers that has identified the genetic mutation causing Proteus syndrome, a rare disorder in which tissue and bone grow massively out of proportion.

11 Aug 2011

Modified spider-silk proteins for nonviral gene delivery

Genetically engineered spider silk could help overcome a major barrier to the use of gene therapy in everyday medicine, according to a new study that reported development and successful initial laboratory tests of such a material. It appears in ACS' journal Bioconjugate Chemistry.

11 Aug 2011

Bristol-Myers Squibb, GNS collaborate to identify biomarkers in immuno-inflammation

GNS Healthcare, Inc., (GNS) the leading healthcare analytics company focused on enabling personalized medicine to improve human health, today announced that it has entered into a collaboration with Bristol-Myers Squibb Company focused on the discovery of novel disease biology and biomarkers in the area of immuno-inflammation.

11 Aug 2011

Can a robot cure cancer?

The Lowy Cancer Research Centre at the University of New South Wales is hosting a select group of high school students and a pair of potentially cancer-curing robots tomorrow ( Friday 12th August) as a curtain raiser for National Science Week, with lab tours led by world-class scientists from Children’s Cancer Institute Australia (CCIA).

10 Aug 2011

Cancer-causing fusion protein works by silencing tumor suppressor gene IL-2Rγ

Mariusz A. Wasik, MD, professor of Pathology and Laboratory Medicine, and Qian Zhang, MD, PhD, research assistant professor, both from the Perelman School of Medicine at the University of Pennsylvania, and their colleagues, found that a cancer-causing fusion protein works by silencing the tumor suppressor gene IL-2R common gamma-chain.

10 Aug 2011

TrovaGene regains ownership of worldwide rights to transrenal technology

TrovaGene, Inc., a developer of transrenal molecular diagnostics, confirmed today that it regained ownership of its worldwide rights and control over its patent estate for transrenal technology for non-invasive prenatal applications and cancer through the termination of a license agreement between TrovaGene and Sequenom, Inc.

10 Aug 2011

Nesfatin-1 protein may help reduce body weight and blood sugar

A newly-identified protein may hold the key to keeping appetite and blood sugar in check, according to a study by York University researchers.

10 Aug 2011

Scientist determines how nyctalopin gene makes night vision possible

A scientist from the Florida campus of The Scripps Research Institute has determined how a particular gene makes night vision possible. The study, which was published in the August 10, 2011 edition of The Journal of Neuroscience, focuses on a gene called nyctalopin. Mutations in the gene result in inherited "night blindness," a loss of vision in low-light environments.

10 Aug 2011

Spermless mosquitoes could reduce spread of malaria, study suggests

In an effort to curb the spread of malaria, researchers from Britain and Italy have genetically altered male mosquitoes so that they do not produce sperm, according to a study published Monday in the Proceedings of the National Academy of Sciences, the Los Angeles Times' "Booster Shots" blog reports.

10 Aug 2011

New technique can help scientists rapidly map myelination

Like explorers mapping a new planet, scientists probing the brain need every type of landmark they can get. Each mountain, river or forest helps scientists find their way through the intricacies of the human brain.

10 Aug 2011

Noninvasive prenatal DNA test can detect fetus at risk for sex-linked disorders

As a noninvasive method of determining the sex of a fetus, tests using cell-free fetal DNA obtained from the mother's blood after 7 weeks gestation performed well, while urine-based tests appear to be unreliable, according to a review and analysis of previous studies, reported in the August 10 issue of JAMA.

10 Aug 2011

A diet of flaxseed shows protective effects against radiation in mice

Flax has been part of human history for well over 30,000 years, used for weaving cloth, feeding people and animals, and even making paint. Now, researchers from the Perelman School of Medicine at the University of Pennsylvania have discovered that it might have a new use for the 21st century: protecting healthy tissues and organs from the harmful effects of radiation.

10 Aug 2011

Scientists reveal why human heart has little regenerative capacity

Stem cell researchers at UCLA have uncovered for the first time why adult human cardiac myocytes have lost their ability to proliferate, perhaps explaining why the human heart has little regenerative capacity.

10 Aug 2011

Researchers demonstrate contribution of Immunoglobulin E to atherogenesis

There is an observed correlation between Immunoglobulin E (IgE) levels atherosclerosis, with twice amount of IgE present in patients with acute myocardial infarction as in patients with stable angina or without coronary heart disease (CHD). Guo-Ping Shi, DSc, Jing Wang, MD, PhD, and colleagues in the Department of Medicine at Brigham and Women's Hospital (BWH), have demonstrated the direct participation of IgE in atherogenesis in a mouse model.

10 Aug 2011

First bioengineered anal sphincter for treatment of fecal and urinary incontinence

Researchers have built the first functional anal sphincters in the laboratory, suggesting a potential future treatment for both fecal and urinary incontinence. Made from muscle and nerve cells, the sphincters developed a blood supply and maintained function when implanted in mice.

10 Aug 2011

Flatworms provide new insight into organ regeneration, evolution of mammalian kidneys

Our bodies are perfectly capable of renewing billions of cells every day but fail miserably when it comes to replacing damaged organs such as kidneys. Using the flatworm Schmidtea mediterranea-famous for its capacity to regrow complete animals from minuscule flecks of tissue-as an eloquent example, researchers at the Stowers Institute for Medical Research demonstrated how our distant evolutionary cousins regenerate their excretory systems from scratch.

10 Aug 2011

New genetic cause of retinitis pigmentosa

Combining the expertise of several different labs, University of Iowa researchers have found a new genetic cause of the blinding eye disease retinitis pigmentosa (RP) and, in the process, discovered an entirely new version of the message that codes for the affected protein.

10 Aug 2011

Vitamin D, UVB may help prevent dental caries

Large geographical variations in dental health and tooth loss among U.S. adolescents and young adults have been reported since the mid-1800s. The first study finding a north-south gradient in dental caries was a report of men rejected from the draft for the Civil War for lost teeth, from 8 per 1000 men in Kentucky to 25 in New England.

10 Aug 2011

Moderate exercise may help prevent cognitive decline after bacterial infection

A small amount of exercise shields older animals from memory loss following a bacterial infection, according to a study in the August 10 issue of The Journal of Neuroscience.

10 Aug 2011

Researchers identify molecular pathway behind inflammation, mucus production in asthma

Researchers at the University of Pittsburgh School of Medicine have identified a molecular pathway that helps explain how an enzyme elevated in asthma patients can lead to increased mucus production and inflammation that is characteristic of the lung condition.

9 Aug 2011