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Ablexis to advance transgenic mouse platform for antibody discovery with $12M Series A financing

Ablexis, LLC, a biotechnology company dedicated to developing an innovative, next-generation platform for antibody drug discovery, announced today that it has completed a $12 million Series A financing. The round was led by Third Rock Ventures and included Pfizer Venture Investments. Proceeds from the financing will be used to continue advancing Ablexis' proprietary AlivaMab Mouse transgenic mouse platform for the discovery of human therapeutic antibodies.

2 Jun 2010

Excess levels of a protein associated with TNF may produce cognitive decline: Studies

Two new studies suggest that excess levels of a protein associated with inflammation, TNF, may produce cognitive decline. TNF regulates both inflammation and brain function. TNF is elevated in the blood in many autoimmune diseases, and in the fluid surrounding the brain in Alzheimer's disease.

2 Jun 2010

Roche, ATCC partner to research real-time endogenous GPCR function with xCELLigence System

G-coupled protein receptors (GPCRs), also known as 7-transmembrane proteins, constitute the single largest class of therapeutic targets for clinical and investigational drugs. There are ~800 predicted members of this class in the human genome, involved in diverse signaling pathways in a wide array of cells and tissue types. Modulation of GPCR function has proven to have therapeutic benefit in a wide variety of diseases in immunology, neurology, cardiology, and oncology.

2 Jun 2010

UCI study provides blueprint for enhanced treatment of inflammatory diseases

By discovering how adult neural stem cells navigate to injury sites in the central nervous system, UC Irvine researchers have helped solve a puzzle in the creation of stem cell-based treatments: How do these cells know where to go? Tom Lane and Kevin Carbajal of the Sue and Bill Gross Stem Cell Research Center found the answer with the body's immune system.

2 Jun 2010

Synthetic peptide repairs, regenerates stroke-injured brain tissue

A synthetic version of a naturally occurring peptide promoted the creation of new blood vessels and repaired damaged nerve cells in lab animals, according to researchers at Henry Ford Hospital in Detroit.

2 Jun 2010

AFFiRiS to explore ProBioGen's HuALN technology for AFFITOME-based vaccination concept

AFFiRiS AG will explore ProBioGen's proprietary Human Artificial Lymph Node Technology (HuALN) as analytical tool for its AFFITOME®-based vaccination concept. Under the contract with ProBioGen, AFFiRiS will evaluate the HuALN technology as a human organoid model to investigate drug-related effects in the context of the human immune system in order to select vaccine candidates best suited to be applied in humans.

2 Jun 2010

Mannitol improves effectiveness of HUCBs in neonatal rat models of cerebral palsy

The sugar-alcohol compound mannitol improved the therapeutic effectiveness of human umbilical cord blood cells injected into neonatal rat models of cerebral palsy, reports a new international study led by the University of South Florida. The mannitol opened the blood-brain barrier by temporarily shrinking the tight endothelial cells that make up the barrier.

2 Jun 2010

Molecules similar to blood-thinning drug heparin can stop malaria from infecting red blood cells: Scientists

New treatments for malaria are possible after Walter and Eliza Hall Institute scientists found that molecules similar to the blood-thinning drug heparin can stop malaria from infecting red blood cells.

2 Jun 2010

CCL5 protein plays protective role against Mycobacterium tuberculosis: New research

Ohio scientists hope to counter the re-emerging threat of tuberculosis with help from proteins from our bodies. In a research report published in the June 2010 print issue of the Journal of Leukocyte Biology, scientists show how the protein CCL5 plays a protective role in helping the body ward off this contagious, airborne disease in the early stages of infection.

2 Jun 2010

Alnylam, Mount Sinai scientists discover svRNAs that play a critical role in influenza A virus replication

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today the publication of new research findings in the journal Proceedings of the National Academy of Sciences (PNAS) by Alnylam scientists and collaborators from Mount Sinai School of Medicine. In the new study, Alnylam and Mount Sinai scientists discovered a novel class of virus-produced small non-coding RNAs, called small viral RNAs (svRNAs), which play a critical role in the replication of influenza A virus.

2 Jun 2010

Platelets play important role in cerebral malaria: Research

Scientists are making strides against cerebral malaria, a fatal form of malaria in children that can ravage the brain and is extremely difficult to treat. New research points to platelets - known for their role in blood clotting - as playing an important role in the disease, stimulating the immune system and turning on molecules that increase inflammation. The inflammation leads to the obstruction of blood vessels in the brain, causing brain damage similar to that seen with a stroke.

2 Jun 2010

Prototype breast cancer vaccine shows promising results in mice

US scientists have developed a prototype breast cancer vaccine that has shown promising results in very early laboratory tests on mice. The vaccine contains a protein called alpha-lactalbumin, which is found in large quantities in the majority of breast cancers.

2 Jun 2010

EMBL scientists identify two small RNA molecules that ensure red blood cell production

Red blood cells, the delivery men that take oxygen to cells all around the body, have short lives. To keep enough of them in circulation, the human body produces around 2 million of these cells every second - even more in response to challenges like severe blood loss. In a study published today in the Journal of Experimental Medicine, scientists at the European Molecular Biology Laboratory in Monterotondo, Italy, and EMBL's European Bioinformatics Institute in Hinxton, UK, have identified two small RNA molecules which ensure that enough red blood cells are produced efficiently, by fine-tuning a number of different genes involved in this process.

2 Jun 2010

Postdoctoral scientists receive NYSCF-Druckenmiller Fellowship award

The New York Stem Cell Foundation (NYSCF) today announced the award of eight new NYSCF-Druckenmiller Fellows. These postdoctoral scientists join 15 accomplished stem cell researchers from leading institutions who have been supported by the program since 2006. NYSCF has awarded 23 fellowships to date.

2 Jun 2010

Sound repetition helps memorize complex sounds

Sound repetition allows us to memorize complex sounds in a very quick, effective and durable way. This form of auditory learning, which was evidenced for the first time by researchers from CNRS, ENS Paris, and Paris Descartes and Toulouse 3 universities, is believed to occur in daily life to help us identify and memorize sound patterns; it allows, for example, immediate recognition of sounds which become familiar through experience, such as the voice of relatives.

1 Jun 2010

Perspectives on computational methods applied to membrane proteins

There have been impressive advances in computational methods, allowing researchers to better understand biological and physiological systems at the atomic level. In its latest Perspectives in General Physiology series, the Journal of General Physiology (JGP) offers an in-depth look at several of these methods and the advantages of each as applied to membrane proteins, with special focus on ion channels.

1 Jun 2010

Sticky gel composed of MPEG-pDHA may help seal wounds created by surgery: Study

A compound found in sunless tanning spray may help to heal wounds following surgery, according to new results published by plastic surgeons from NewYork-Presbyterian Hospital/Weill Cornell Medical Center in New York City and biomedical engineers at Cornell University in Ithaca, N.Y., where the novel compound was developed.

1 Jun 2010

More insight into key receptor that influences effectiveness of serotonin-related antidepressants

University of Michigan scientists have provided the most detailed picture yet of a key receptor in the brain that influences the effectiveness of serotonin-related antidepressants, such as Prozac.

1 Jun 2010

University of California scientists identify new kinase that regulates cell proliferation, migration

Scientists at the University of California, San Diego have identified a previously unknown kinase that regulates cell proliferation, shape and migration, and may play a major role in the progression or metastasis of cancer cells.

1 Jun 2010

Commonalities between flies and humans make valuable new model for galactosemia

Galactosemia is a metabolic disease resulting from an inherited defect that prevents the proper metabolism of galactose, a sugar commonly found in dairy products, like milk. Exposure of affected people to galactose, can damage most of their organ systems and can be fatal. The ability to study the disease is limited by a lack of animal models.

1 Jun 2010

Medical Science News

Ablexis to advance transgenic mouse platform for antibody discovery with $12M Series A financing

Excess levels of a protein associated with TNF may produce cognitive decline: Studies

Roche, ATCC partner to research real-time endogenous GPCR function with xCELLigence System

UCI study provides blueprint for enhanced treatment of inflammatory diseases

Synthetic peptide repairs, regenerates stroke-injured brain tissue

AFFiRiS to explore ProBioGen's HuALN technology for AFFITOME-based vaccination concept

Mannitol improves effectiveness of HUCBs in neonatal rat models of cerebral palsy

Molecules similar to blood-thinning drug heparin can stop malaria from infecting red blood cells: Scientists

CCL5 protein plays protective role against Mycobacterium tuberculosis: New research

Alnylam, Mount Sinai scientists discover svRNAs that play a critical role in influenza A virus replication

Platelets play important role in cerebral malaria: Research

Prototype breast cancer vaccine shows promising results in mice

EMBL scientists identify two small RNA molecules that ensure red blood cell production

Postdoctoral scientists receive NYSCF-Druckenmiller Fellowship award

Sound repetition helps memorize complex sounds

Perspectives on computational methods applied to membrane proteins

Sticky gel composed of MPEG-pDHA may help seal wounds created by surgery: Study

More insight into key receptor that influences effectiveness of serotonin-related antidepressants

University of California scientists identify new kinase that regulates cell proliferation, migration

Commonalities between flies and humans make valuable new model for galactosemia

The Proteoform Puzzle: Unlocking the Next Frontier

Synthetic Biology and the Pursuit of Living Diagnostics

Modular, Scalable, Intelligent: How n6 Is Rethinking NGS Library Prep

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