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Report: 34 C>G of PPAR-γ gene might be a potential therapeutic target for colon cancer

Colorectal cancer is one of the major causes of cancer death in the developed countries. Accumulated evidences indicate that lipid metabolism, especially the one in the arachidonic acid -pathway, appears to play a critical role in the development of CRC.

7 May 2010

New report: Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease

Claims about the health benefits of foods and nutritional supplements have proliferated in recent years, most of them based on studies measuring ingredients' effects on biomarkers as substitutes for actual clinical outcomes.

7 May 2010

Chemical changes in genetic material regulate activity of many genes

Chemical changes in the genetic material, known as epigenetic modifications, regulate the activity of many genes. Thus, attachment of methyl groups to DNA often inactivates important cellular growth brakes. Therefore, this process called methylation is believed to be a major cause of uncontrolled division of cancer cells. Specific enzymes, the DNA methyltransferases, are responsible for methylation.

7 May 2010

S2S hosts students from Newark Science Park High School for a day of hands-on science

Students 2 Science, Inc. hosted students from Newark Science Park High School for a day of hands-on science as part of its year-long "Supercharged Science" program.

7 May 2010

Researchers investigate aberrant expression of nuclear matrix proteins in gastric cancer cells

Gastric cancer is the most common malignant gastrointestinal cancer and accounts for 25% of cancer deaths. Nuclear matrix, a filamentous protein framework for eukaryotic cellular chromatin, closely relates to DNA duplication and transcription. Research on nuclear matrix proteins will provide insight into how tumors developed.

7 May 2010

Encouraging B. anthracis to unwittingly unmask itself will help eradicate the pathogen

Anthrax-causing bacteria can be engineered to shed their invisibility cloaks, making it easier for the immune system to eradicate it, according to a new study published in Microbiology. The work could lead to new measures to treat anthrax infection in the event of a biological warfare attack.

7 May 2010

Cytori Therapeutics to initiate European medical device approval study for Celution System

The first clinical trial of adipose (fat) tissue-derived stem and regenerative cells for the treatment of heart attacks showed a substantial reduction in the size of injury to the heart, an improvement in the amount of blood supply to the heart muscle, and a corresponding functional improvement in the amount of blood the heart can pump.

7 May 2010

Plant breeding can be used to produce new types of wheat with enhanced health benefits

Wheat products, and in particular, wholegrain products, are important sources of dietary fibre, vitamins, minerals and other components which are beneficial for human health. Analysis of a diverse range of wheat varieties within the HEALTHGRAIN project of the European Union has shown substantial variation (up to four-fold) in the content and composition of these components.

7 May 2010

Halozyme Therapeutics first-quarter net loss decreases to $11.8 million

Halozyme Therapeutics, Inc., a biopharmaceutical company developing and commercializing products targeting the extracellular matrix for the endocrinology, oncology, dermatology and drug delivery markets, today reported financial results for the first quarter ended March 31, 2010.

7 May 2010

Fragile X syndrome iPS cells and embryonic stem cells behave differently: Study

In the last three years, a new technique for reprogramming adult cells has given scientists an easier and less controversial way to harness the power of embryonic-like stem cells to study human disease from its earliest beginnings in hopes of gleaning new insights into the root causes of disease and developing new therapies.

7 May 2010

Manual provides laboratory methods, information and resources on new collection of model species

Mice, frogs, and E. coli are standard organisms in biology laboratories. But in the last few years, due in part to technical advances, the reduced costs of genome sequencing, and increased interest in evolution and development, the range of organisms used for research has greatly expanded. Scientists now have more flexibility in choosing a model system that might better address their specific research question.

7 May 2010

Closer to understanding age-related memory loss and drug to boost memory

The world's scientific community may be one step closer to understanding age-related memory loss, and to developing a drug that might help boost memory. In an editorial published May 7 in Science, J. David Sweatt, Ph.D., chair of the University of Alabama at Birmingham (UAB) Department of Neurobiology, says that drugs known as histone deacetylase inhibitors are showing great promise in stopping memory loss - and even in boosting the formation of memory in animal models.

7 May 2010

DNA capture techniques enable sequencing of ancient Neandertal DNA

Researchers from the Max Planck Institute (MPI), Cold Spring Harbor Laboratory (CSHL), Agilent Technologies Inc., and other prestigious institutions worldwide have shown that DNA capture techniques can greatly enable the sequencing of ancient Neandertal DNA, providing new insight into the nature of these prehistoric hominids.

7 May 2010

ETH Zurich researchers discover HIV transmission chains

Since the emergence of the first AIDS cases in the early 1980s, an infectious wave has spread over Switzerland. Every year, several hundred people are infected with the HI-virus which triggers the acquired immunodeficiency syndrome, AIDS. Does the infection spread according to a particular pattern? Do these patterns vary among the transmission groups such as drug addicts, homosexual or heterosexual persons?

7 May 2010

Kaposi's Sarcoma-associated herpesvirus replicates, spreads by hijacking PYM cellular protein

Research from the University of Leeds has identified how the virus which causes Kaposi's Sarcoma replicates and spreads - opening a door to a possible new treatment for the disease.

7 May 2010

Gene patenting policies affect patient access to testing for disease-causing genes: Study

Policies allowing genes to be patented can make it more difficult for patients to access testing for important disease-causing gene mutations, according to a series of papers in a special online supplement published by Genetics in Medicine, the official peer-reviewed journal of The American College of Medical Genetics.

7 May 2010

Ohio scientists demonstrate existence of effective technology for nationwide newborn screening of SMA

Scientists in Ohio studying Spinal Muscular Atrophy (SMA) have concluded that the technology now exists to carry out nationwide screening of newborn children and pregnant mothers. The study, published in the American Journal of Medical Genetics, reveals that effective screening may allow parents to find proactive treatments before the symptoms become irreversible.

7 May 2010

Inadvertent reprogramming of genes in peripheral nervous system may cause chronic pain

Chronic pain severely limits patients' quality of life and is among the cost drivers in U.S. health care. Patients can suffer pain without an apparent cause and often fail to respond to available treatments. Mayo Clinic researchers and collaborators now report that chronic pain may be caused by the inadvertent reprogramming of more than 2,000 genes in the peripheral nervous system. The research findings appear in the current issue of the journal Genome Research.

7 May 2010

SBMC 2010 to focus on systems-biological analysis of processes in mammalian cells

More targeted drug development thanks to systems biology - scientists at the SBMC 2010 in Freiburg explain how this works. Systems biology has finally come of age. Evidence for this is the third Conference on Systems Biology of Mammalian Cells (SBMC), which will take place on June 3-5, 2010 at the Concert Hall Freiburg (Konzerthaus) under the auspices of Prof. Dr. Annette Schavan, German Federal Minister of Education and Research.

7 May 2010

Movements of satellite cells could help patients with muscular dystrophy: MU researchers

When muscle tissue experiences trauma or disease, such as muscular dystrophy, stem cells in the muscle known as "satellite cells" respond to repair and regenerate the muscle. These cells are particularly important in neuromuscular diseases, such as muscular dystrophy, which affect muscle stability and repair.

7 May 2010

Medical Science News

Report: 34 C>G of PPAR-γ gene might be a potential therapeutic target for colon cancer

New report: Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease

Chemical changes in genetic material regulate activity of many genes

S2S hosts students from Newark Science Park High School for a day of hands-on science

Researchers investigate aberrant expression of nuclear matrix proteins in gastric cancer cells

Encouraging B. anthracis to unwittingly unmask itself will help eradicate the pathogen

Cytori Therapeutics to initiate European medical device approval study for Celution System

Plant breeding can be used to produce new types of wheat with enhanced health benefits

Halozyme Therapeutics first-quarter net loss decreases to $11.8 million

Fragile X syndrome iPS cells and embryonic stem cells behave differently: Study

Manual provides laboratory methods, information and resources on new collection of model species

Closer to understanding age-related memory loss and drug to boost memory

DNA capture techniques enable sequencing of ancient Neandertal DNA

ETH Zurich researchers discover HIV transmission chains

Kaposi's Sarcoma-associated herpesvirus replicates, spreads by hijacking PYM cellular protein

Gene patenting policies affect patient access to testing for disease-causing genes: Study

Ohio scientists demonstrate existence of effective technology for nationwide newborn screening of SMA

Inadvertent reprogramming of genes in peripheral nervous system may cause chronic pain

SBMC 2010 to focus on systems-biological analysis of processes in mammalian cells

Movements of satellite cells could help patients with muscular dystrophy: MU researchers

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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