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Molecular master switch plays a key role in maturation process of brain cells

About four out of every 10 cells in the brain are so-called oligodendrocytes. These cells produce the all-important myelin that coats nerve tracts, ensuring fast, energy-efficient transmission of nerve impulses.

11 Mar 2010

MBL scientists develop novel methods to interpret cellular dynamics

If you can imagine identical twin sisters at rest, their breath drawing them subtly together and apart, who somehow latch onto ropes that pull them to opposite sides of the bed-you can imagine what happens to a chromosome in the dividing cell.

11 Mar 2010

Researchers identify new treatment strategy for lymphoma

Seaweed extract may eventually emerge as a lymphoma treatment, according to laboratory research presented at the second AACR Dead Sea International Conference on Advances in Cancer Research: From the Laboratory to the Clinic, held here March 7-10, 2010.

11 Mar 2010

Cytokeratins 8 and 18 can strongly enhance breast cancer drug fulvestrant's anti-estrogenic activity

Women's responsiveness to the second-line breast cancer drug fulvestrant may depend on whether the cancer cells are expressing two key proteins, Indiana University Bloomington scientists report in this month's Cancer Biology & Therapy.

11 Mar 2010

Ampicillin activates torsinA, improves cell function to reduce movement disorders

Discovery of an antibiotic's capacity to improve cell function in laboratory tests is providing movement disorder researchers with leads to more desirable molecules with potentially similar traits, according to University of Alabama scientists co-authoring a paper publishing March 10 in the journal Disease Models & Mechanisms.

11 Mar 2010

Genetic mutation in African-American men with family history of prostate cancer discovered

Shahriar Koochekpour, MD, PhD, Assistant Professor of Microbiology and Immunology, Biochemistry and Molecular Biology, and Genetics at LSU Health Sciences Center New Orleans, led research that has discovered, for the first time, a genetic mutation in African-American men with a family history of prostate cancer who are at increased risk for the disease.

11 Mar 2010

Aastrom Biosciences treats final patient in IMPACT-DCM Phase 2 surgical clinical trial

Aastrom Biosciences, Inc., a leading developer of autologous cellular therapies for the treatment of severe cardiovascular diseases, today reported the final patient treatment in the company's ongoing U.S. Phase 2 surgical clinical trial designated IMPACT-DCM.

10 Mar 2010

TGen deploys Isilon IQ to power multiple genome sequencing devices to discover new treatments for diseases

Isilon® Systems today announced that The Translational Genomics Research Institute has deployed Isilon scale-out NAS as the primary storage solution powering its next-generation biomedical research. By using Isilon IQ to power multiple genome sequencing devices, TGen has unified its mission-critical operations onto a single, high-performance, highly scalable shared pool of storage, increasing workflow productivity and reducing costs to accelerate the discovery of new treatments for life-threatening diseases.

10 Mar 2010

Children's Hospital Boston develops new web site, releases video message on current state of stem cell research

Exactly one year to the day after President Obama's historic decision to reverse an eight-year restriction on federally funded embryonic stem cell research, the Children's Hospital Boston Stem Cell Program today announced the development of a unique, comprehensive web site and released a candid video message from its top researchers on the current state of stem cell research to introduce the new site: stemcell.childrenshospital.org.

10 Mar 2010

TNS acquires license to Ergothioneine Transporter from University of Cologne

Total Nutraceutical Solutions, Inc. announced that the company has acquired from the University of Cologne, Cologne, Germany, an exclusive license agreement on the invention entitled “Ergothioneine Transporter,” owned by the University.

10 Mar 2010

Protein competition over MAPK provides mechanism to integrate different signals directing early embryonic development

A Princeton University-led research team has discovered that protein competition over an important enzyme provides a mechanism to integrate different signals that direct early embryonic development. The work suggests that these signals are combined long before they interact with the organism's DNA, as was previously believed, and also may inform new therapeutic strategies to fight cancer.

10 Mar 2010

Sonic hedgehog gene also at work in the ectoderm

Sonic hedgehog, a gene that plays a crucial rule in the positioning and growth of limbs, fingers and toes, has been confirmed in an unexpected place in the embryos of developing mice - the layer of cells that creates the skin.

10 Mar 2010

BIOCRATES Life Sciences, CHENOMX announce co-marketing agreement

Austrian biomarker developer BIOCRATES Life Sciences AG announced today that it entered a co-marketing agreement with Canadian-based CHENOMX Inc. Both enterprises focus on a new and highly promising technology aimed at generating a metabolic profile of the human organism that can be used to monitor the effects of disease, nutrition, toxins, environment, or drugs on an organism.

10 Mar 2010

Cellzome, GSK form second major alliance to develop new anti-inflammatory drugs

Cellzome today announced that it has formed a second strategic alliance with GlaxoSmithKline (GSK). This new collaboration gives GSK exclusive access to Cellzome's proprietary Episphere(TM) technology in the emerging field of epigenetics as applied to immunoinflammatory disease. Epigenetic mechanisms play a key role in controlling immune cell differentiation and inflammatory gene expression during an excessive inflammatory response.

10 Mar 2010

End-of-life directives prevail over preferences and objections in woman’s desire to be cryonically preserved

In one of the more unusual cases to confront the Colorado courts, the El Paso County Probate Court in Colorado Springs has granted Holme Roberts & Owen (HRO) client Alcor Life Extension Foundation of Scottsdale, Arizona, custody of the remains of Colorado Springs nurse Mary Robbins. The ruling upheld Ms. Robbins’s 2006 agreement with Alcor to have her head cryonically preserved after death, hoping that future technologies could bring her back to life.

10 Mar 2010

Genetic basis unknown in many children with mental retardation and developmental delays

Researchers from four laboratories that perform diagnostic genetic testing of chromosome abnormalities in individuals with unexplained physical and developmental disabilities recently identified a previously unrecognized genetic disorder.

10 Mar 2010

Insulin resistance in Hepatitis C patients: Mostly in muscle and not in liver

We have known for several years that Hepatitis C, a common cause of liver cirrhosis and cancer, also makes people three to four times more likely to develop Type 2 diabetes.

10 Mar 2010

Papaya's anticancer effect against broad range of lab-grown tumors documented

The humble papaya is gaining credibility in Western medicine for anticancer powers that folk cultures have recognized for generations.

10 Mar 2010

AMT initiates dosing in Phase I/II gene therapy clinical trial for hemophilia B

Amsterdam Molecular Therapeutics, a leader in the field of human gene therapy, announced today that the first patient has been dosed in the Phase I/II exploratory clinical trial with a gene therapy product for hemophilia B, a seriously debilitating and potentially lethal disease.

10 Mar 2010

Lowering levels of Coonexin46 with use of siRNA will help prevent tumor formation

What began as research into how diabetics could possibly preserve their eyesight has led to findings that could prolong the vision of children afflicted with retinoblastoma.

10 Mar 2010

Medical Science News

Molecular master switch plays a key role in maturation process of brain cells

MBL scientists develop novel methods to interpret cellular dynamics

Researchers identify new treatment strategy for lymphoma

Cytokeratins 8 and 18 can strongly enhance breast cancer drug fulvestrant's anti-estrogenic activity

Ampicillin activates torsinA, improves cell function to reduce movement disorders

Genetic mutation in African-American men with family history of prostate cancer discovered

Aastrom Biosciences treats final patient in IMPACT-DCM Phase 2 surgical clinical trial

TGen deploys Isilon IQ to power multiple genome sequencing devices to discover new treatments for diseases

Children's Hospital Boston develops new web site, releases video message on current state of stem cell research

TNS acquires license to Ergothioneine Transporter from University of Cologne

Protein competition over MAPK provides mechanism to integrate different signals directing early embryonic development

Sonic hedgehog gene also at work in the ectoderm

BIOCRATES Life Sciences, CHENOMX announce co-marketing agreement

Cellzome, GSK form second major alliance to develop new anti-inflammatory drugs

End-of-life directives prevail over preferences and objections in woman’s desire to be cryonically preserved

Genetic basis unknown in many children with mental retardation and developmental delays

Insulin resistance in Hepatitis C patients: Mostly in muscle and not in liver

Papaya's anticancer effect against broad range of lab-grown tumors documented

AMT initiates dosing in Phase I/II gene therapy clinical trial for hemophilia B

Lowering levels of Coonexin46 with use of siRNA will help prevent tumor formation

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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