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AlphaMissense revolutionizes genetic mutation analysis for disease prediction

AlphaMissense, an adaptation of AlphaFold, offers a highly accurate model for predicting the pathogenicity of human proteome-wide missense variants at the single amino acid level. The model outperforms existing methods, providing valuable insights for diagnosing rare diseases and developing targeted therapies.

20 Sep 2023

Uncontrolled hypertension wreaks havoc on global health and economies

The World Health Organization's recent report underscores the global health and economic crisis posed by uncontrolled hypertension, affecting one in five people worldwide. The study calls for urgent, coordinated government action, emphasizing that effective hypertension management could prevent millions of deaths and offer an 18-to-1 return on investment.

20 Sep 2023

Calm and hope may be promising routes to psychological wellbeing after crisis

Periods of collective stress, such as a pandemic or climate crisis, have a major impact on our psychological wellbeing.

20 Sep 2023

Study uncovers how a newborn's cry triggers breast milk release in mothers

Hearing the sound of a newborn's wail can trigger the release of oxytocin, a brain chemical that controls breast milk release in mothers, a new study in rodents shows.

20 Sep 2023

Creating CAR-T cells with enhanced immune memory to fight cancer

Among available immunotherapies, the use of «CAR-T» cells is proving extremely effective against certain blood cancers, but only in half of patients.

20 Sep 2023

Journal of Pediatric Rehabilitation Medicine publishes supplement on spina bifida research and care

A supplement to the Journal of Pediatric Rehabilitation Medicine (JPRM) published by IOS Press, presents a compendium of abstracts from the 2023 World Congress on Spina Bifida Research and Care.

20 Sep 2023

New brain biomarker predicts recovery from treatment-resistant depression

Using a novel deep brain stimulation (DBS) device capable of recording brain signals, researchers have identified a pattern of brain activity or "biomarker" related to clinical signs of recovery from treatment-resistant depression.

20 Sep 2023

Flagellin immunization protects mice from detrimental effects of dietary emulsifiers

In a new study, mice whose immune systems were trained against the microbial protein flagellin did not experience the usual detrimental effects of ingesting food additive emulsifiers, pointing to a potential new way to combat various chronic inflammatory diseases.

20 Sep 2023

Study identifies a molecule that may be behind COVID-19 brain fog

A study identifies a molecule that may be behind cognitive symptoms, including "brain fog," experienced by those infected by the SARS-CoV-2 virus.

20 Sep 2023

Vaccine impact: BNT162b2 and pediatric COVID-19 ambulatory visits in kids under 5

The association between BNT162b2 vaccine and (COVID-19)-related ambulatory visits.

20 Sep 2023

Game-changing point-of-care assay could revolutionize Mpox detection worldwide

Researchers developed a point-of-care assay for the rapid detection of mpox virus.

20 Sep 2023

Subclonal neoantigens present a key roadblock in MMRd tumor immunotherapy success

Researchers evaluated sensitivity to immune checkpoint blockade (ICB) therapy.

20 Sep 2023

Could reducing light exposure help you sleep better and improve your mental health during pregnancy?

Higher light exposure at night and poor sleep quality are associated with poorer mental health outcomes.

20 Sep 2023

Researchers challenge WHO's sweetener guidelines, call for urgent re-evaluation

Researchers question WHO guidelines on non-sugar sweeteners, citing a reliance on biased prospective cohort studies over randomized controlled trials. The study calls for an urgent re-evaluation of WHO's stance, as recent evidence suggests non-sugar sweeteners may actually reduce cardiometabolic risks.

19 Sep 2023

Is sucralose the safer sweetener for your gut health?

The study found that consuming a beverage sweetened with sucrose significantly increased bacterial endotoxin levels in the blood, a marker for inflammation and gut barrier dysfunction, while no such effect was observed with sucralose-sweetened drinks. The findings suggest that sucralose may be a safer alternative to sucrose in terms of intestinal health and inflammation.

19 Sep 2023

Mapping the human body one cell at a time: New study reveals the intricate relationship between cell size and count

A study published in PNAS provides a comprehensive look at the relationship between cell size and count across the human body, drawing from over 1,500 sources and identifying around 400 unique cell types. The research reveals an almost inverse relationship between cell size and count, offering a quantitative framework that could serve as a baseline for understanding cellular composition and function in various applications.

19 Sep 2023

Can a plant-based diet lower your risk of Parkinson's disease?

A recent study in the journal Movement Disorders examined the association between plant-based diets and Parkinson's disease (PD) risk, using data from 126,283 UK Biobank participants. The research found that those in the highest quartile for healthful plant-based diet indices (hPDI) had a 22% lower risk of PD, while unhealthful plant-based diets (uPDI) correlated with a 38% higher risk.

19 Sep 2023

Real-time live tissue sensitivity assay could be used as a personalized strategy for pancreatic cancer

A new research paper was published in Oncotarget's Volume 14 on September 15, 2023, entitled, "Real time ex vivo chemosensitivity assay for pancreatic adenocarcinoma."

19 Sep 2023

Rehabilitation for chronic knee pain may not be targeting all the right muscles

A new study from the University of Connecticut has discovered that rehabilitation to address chronic knee pain may not be targeting all the right muscles.

19 Sep 2023

Transforming postpartum depression treatment with neurosteroids

A new study in Neuropsychopharmacology delves into the mechanisms of action of brexanolone, the first FDA-approved, rapid-acting antidepressant specifically for postpartum depression (PPD). The research highlights brexanolone's potential anti-inflammatory effects and its impact on GABAA receptors, offering insights into its efficacy and suggesting avenues for further study.

19 Sep 2023