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WHO releases new data on worldwide influenza activity

The latest WHO report updated up to 30 October 2022 has data categorized by influenza transmission zones, i.e., countries/regions with similar influenza transmission patterns.

17 Nov 2022

What is the immune protection generated by SARS-CoV-2 Delta and Omicron BA.1 and BA.2 against Omicron BA.4 and BA.5?

Researchers evaluated immune protection conferred by previous SARS-CoV-2 Delta variant and Omicron BA.1/BA.2 subvariant infections and updated vaccines against Omicron BA.4/5 infections and associated hospitalizations.

17 Nov 2022

Evaluating differences in viral and symptom rebounds between Paxlovid-treated and untreated COVID-19 patients

Researchers evaluated differences in viral and symptom rebounds between Paxlovid-treated and untreated coronavirus disease 2019 (COVID-19) patients.

17 Nov 2022

What is the prevalence of contraindications to Paxlovid among hospitalized COVID-19 patients?

Researchers examined the prevalence of contraindications to nirmatrelvir-ritonavir (Paxlovid) in hospitalized coronavirus disease 2019 (COVID-19) patients.

17 Nov 2022

Study describes distinct pattern of ongoing respiratory syncytial virus transmission in the Netherlands after the COVID-19 pandemic

Researchers assessed respiratory syncytial virus (RSV) transmission after the coronavirus disease 2019 (COVID-19) pandemic in the Netherlands.

17 Nov 2022

Comparing post–COVID-19 symptoms two years after SARS-CoV-2 infection

Researchers compared the presence of post–coronavirus disease 2019 (COVID-19) symptoms among hospitalized and non-hospitalized patients in Spain.

17 Nov 2022

Protection afforded by SARS-CoV-2 infection against reinfection when Omicron BA.5 was the dominating subvariant in Scania county, Sweden

Researchers from Sweden conducted a cohort study to evaluate the protection granted by previous SARS-CoV-2 Omicron subvariant infections against reinfections among individuals vaccinated between June and August 2022.

17 Nov 2022

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

Researchers presented a functional analysis of the SARS-CoV-2 open reading frame 3c (ORF3c) protein.

17 Nov 2022

Study concludes monkeypox virus is readily detected by qPCR using three clinically validated assays

Researchers validated monkeypox virus (MPXV) quantitative polymerase chain reaction (qPCR) assays.

17 Nov 2022

Researchers identify a conserved site on SARS-CoV-2 spike that a broadly neutralizing macrocyclic peptide can target

Researchers explored the efficiency of a macrocyclic peptide in inhibiting the SARS-CoV-2 spike protein.

17 Nov 2022

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

Researchers characterized the expression of IFN-1 and IFN-2, ISGs, and NF-κB in the upper respiratory tracts of patients with mild and severe COVID-19, to understand innate immune responses to SARS-CoV-2 infections.

17 Nov 2022

When is it best to use dose-sparing vaccination strategies for monkeypox to protect more people?

Researchers evaluated dose-sparing strategies for monkeypox (MPX) vaccination using mathematical modeling.

17 Nov 2022

Study uncovers new rules for lineage progression

The hypothalamus, one of the most complex brain regions in the mammalian nervous system, contains an astonishing heterogeneity of neurons that regulate endocrine, autonomic and behavioral functions. It not only regulates food consumption, water intake, body temperature, circadian rhythm and sleep to maintain the survival of individual organisms, but also controls puberty onset and reproductive behavior to sustain the breeding population.

17 Nov 2022

Potential effects of nonoral versus oral gender-affirming estrogen therapy

A comprehensive review of research into the delivery method of estrogen treatment (e.g., oral, intramuscular injection, transdermal patch, etc.) and cardiovascular risk in transgender women and gender-diverse people found that treatment route may affect heart health, but there is not enough available data for metanalysis. The study is published ahead of print in the American Journal of Physiology-Heart and Circulatory Physiology. It was chosen as an APSselect article for November.

17 Nov 2022

Research highlights an understudied aspect of Alzheimer’s disease

Memory loss is often the first sign of Alzheimer's disease, followed by confusion and difficulty thinking. These symptoms reflect the typical pattern of worsening damage to brain tissues. Toxic clusters of proteins first concentrate in the temporal lobes of the brain - the memory area - before spreading to parts of the brain important for thinking and planning.

17 Nov 2022

Inhibitory neuron dysfunction emerges as a modulable mechanism of hyperexcitability

A small group of brain cells linked in a circuit is responsible for setting off whole-brain seizures in a rare form of epilepsy affected by blood sugar levels, a study led by UT Southwestern researchers suggests. The finding, published in Science Translational Medicine, could lead to new treatments for other metabolic disorders in the brain, the authors said.

17 Nov 2022

Omicron BA.2 causes more symptoms and a greater disruption to daily life

In a recent study published in the Nature Communications journal, researchers monitored the changing symptom profiles associated with different severe acute respiratory syndrome CoV-2 (SARS-CoV-2) variants, especially Omicron subvariants BA.1 and BA.2.

16 Nov 2022

Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus

In a recent study posted to the bioRxiv* preprint server, researchers evaluated responses of natural killer (NK) lymphocytes to VACV (vaccinia virus) infections in vivo.

16 Nov 2022

SARS-CoV-2 ‘Deltacron’ variant exhibits immune-escape properties similar to Omicron BA.1

The SARS-CoV-2 Deltacron does not exhibit higher transmissibility or immune evasion than the Omicron BA.1 variant.

16 Nov 2022

Study reveals neglected or late TB diagnoses related to COVID-19

In a recent study published in the journal BMJ Medicine, researchers modeled changing patterns in sex- and age-stratified new and relapse tuberculosis (TB) case notifications reported to the World Health Organization (WHO) for 45 nations with high TB, TB/human immunodeficiency virus (HIV) and multidrug-resistant TB (MDR-TB) burden between 2013 and 2019 due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

16 Nov 2022

Medical Science News

WHO releases new data on worldwide influenza activity

What is the immune protection generated by SARS-CoV-2 Delta and Omicron BA.1 and BA.2 against Omicron BA.4 and BA.5?

Evaluating differences in viral and symptom rebounds between Paxlovid-treated and untreated COVID-19 patients

What is the prevalence of contraindications to Paxlovid among hospitalized COVID-19 patients?

Study describes distinct pattern of ongoing respiratory syncytial virus transmission in the Netherlands after the COVID-19 pandemic

Comparing post–COVID-19 symptoms two years after SARS-CoV-2 infection

Protection afforded by SARS-CoV-2 infection against reinfection when Omicron BA.5 was the dominating subvariant in Scania county, Sweden

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

Study concludes monkeypox virus is readily detected by qPCR using three clinically validated assays

Researchers identify a conserved site on SARS-CoV-2 spike that a broadly neutralizing macrocyclic peptide can target

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

When is it best to use dose-sparing vaccination strategies for monkeypox to protect more people?

Study uncovers new rules for lineage progression

Potential effects of nonoral versus oral gender-affirming estrogen therapy

Research highlights an understudied aspect of Alzheimer’s disease

Inhibitory neuron dysfunction emerges as a modulable mechanism of hyperexcitability

Omicron BA.2 causes more symptoms and a greater disruption to daily life

Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus

SARS-CoV-2 ‘Deltacron’ variant exhibits immune-escape properties similar to Omicron BA.1

Study reveals neglected or late TB diagnoses related to COVID-19

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

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