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Minimally invasive procedure enables patients to be out of the hospital within a few days

Minimally invasive, catheter-based transcatheter aortic valve replacement (TAVR) has revolutionized treatment of aortic stenosis (AS), and both American and European guidelines have approved its use. However, there is a perception that TAVR is more expensive than surgical aortic valve replacement (SAVR). A budget impact analysis comparing the two options now shows that TAVR is an affordable and effective strategy for the treatment of AS. The study appears in the Canadian Journal of Cardiology, published by Elsevier.

12 Sep 2022

Tumor-infiltrating lymphocytes therapy treats cancers at a large scale

A novel treatment strategy with personalized cell therapy significantly improves progression-free survival compared to standard immunotherapy in patients with advanced melanoma, according to ground-breaking results reported at the ESMO Congress 2022 from the phase 3 M14TIL trial.

12 Sep 2022

Pollutant particles in the air trigger lung cancer in non-smokers

A new mechanism has been identified through which very small pollutant particles in the air may trigger lung cancer in people who have never smoked, paving the way to new prevention approaches and development of therapies, according to late-breaking data [to be] reported at the ESMO Congress 2022 by scientists of the Francis Crick Institute and University College London, funded by Cancer Research UK. The particles, which are typically found in vehicle exhaust and smoke from fossil fuels, are associated with non-small cell lung cancer (NSCLC) risk, accounting for over 250,000 lung cancer deaths globally per year.

12 Sep 2022

Tumor-derived factors stimulate effector trogocytosis and inhibit CAR T cells

The immune system is equipped to respond not just to external invaders - think viruses, bacteria, and parasites - but also to internal threats, namely, cancer. Yet, frequently, malignancies overcome the immune system's defenses and evade detection.

12 Sep 2022

Antibody escape less pronounced with BA.2.75 compared to BA.4/5

In a recent study published in the Lancet, researchers evaluated the antibody neutralization sensitivity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2.75 subvariant.

11 Sep 2022

Discovery of antibodies that may eliminate the need for COVID vaccines

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11 Sep 2022

Climate change has increased the risk of bat-borne pathogen spillover

In a recent study posted to the bioRxiv* preprint server, researchers retrospectively assessed the association between climate change and disease spillover risks triggered by bat distribution changes based on historical climate and vampire-bat occurrence data for the previous century (1900-2020).

11 Sep 2022

St. Baldrick's Scholar grant awarded to CU researcher for investigating new drug to treat infant leukemia

As part of its ongoing efforts to eradicate childhood cancers, the St. Baldrick's Foundation has awarded University of Colorado Cancer Center member Kelly Faulk, MD, a St. Baldrick's Scholar grant to investigate a new method for treating infant leukemia.

9 Sep 2022

Gut microbes can also impact a person's neurological and emotional health, UTSW researcher says

The role of the microbiome in intestinal and systemic health has garnered close attention among researchers for many years.

9 Sep 2022

Scientists reverse the effects of lysosomal storage disorders in patient cells and mice

Scientists at the Icahn School of Medicine at Mount Sinai in New York, the National Center for Advancing Translational Sciences (NCATS), and elsewhere have reversed the effects of several life-threatening inherited neurodegenerative diseases called lysosomal storage disorders (LSDs) in patient cells and mice.

9 Sep 2022

Distribution of platinum after chemotherapy may help predict resistance to ovarian cancer treatment

A team of researchers from Japan has discovered that the distribution of platinum within a tumor following platinum-based chemotherapy treatment of ovarian cancer may predict whether the tumor will be resistant to further treatment.

9 Sep 2022

Weill Cornell Medicine receives $61.9 million NIH grant to continue funding its Clinical and Translational Science Center

Weill Cornell Medicine was awarded a $61.9 million grant from the National Institutes of Health's National Center for Advancing Translational Sciences to continue funding its Clinical and Translational Science Center until 2027.

9 Sep 2022

Potential HIV vaccine component leads to strong protection in primates

To block infection from HIV, a successful vaccine will require a combination of ingredients, including at least three antibody targets and a substance that boosts immune responses.

9 Sep 2022

Early life exposure to antibiotics can have long-lasting effects on adult gut health

Preterm and low birth weight babies are routinely given antibiotics to prevent, not just treat, infections, which they have a high risk of developing.

9 Sep 2022

Can cod liver oil supplementation prevent COVID-19 and other acute respiratory infections?

A new study aimed to analyze whether cod liver oil could prevent serious COVID-19, SARS-CoV-2 infection, or other acute respiratory infections during the winter of 2020-2021.

9 Sep 2022

The use of AlphaFold2-enabled molecular docking simulations to predict protein-ligand interactions for antibiotic drug discovery

Researchers demonstrated that advances in modeling protein-ligand interactions using machine learning-based approaches are needed to exploit AlphaFold2 for antibiotic discovery better.

9 Sep 2022

Factors influencing patient’s perception during COVID-19 recovery

A team of researchers characterized individual-level illness perception, both cognitive and emotional, following COVID-19.

9 Sep 2022

COVID-19’s long-term impact on orphanhood and caregiver loss

Researchers performed epidemiologic modeling to update COVID-19-associated caregiver and parent loss estimates.

9 Sep 2022

The evolution of humoral immune responses over the course of Epstein-Barr virus infection

Researchers explored probable humoral immune mechanisms related to EBV curtailment, besides neutralization, by a systematic emphasis on antibody fragment crystallizable-functional activities over the course of EBV infections.

9 Sep 2022

Scientists identify genetic variants linked to an increased risk of developing Hodgkin lymphoma

Why did my child get cancer? Clinicians have longed for a way to help answer this question. Doctors knew Hodgkin lymphoma sometimes occurs in families, but why this happens has been a mystery. Scientists at St. Jude Children's Research Hospital have now helped solve it.

9 Sep 2022

Medical Science News

Minimally invasive procedure enables patients to be out of the hospital within a few days

Tumor-infiltrating lymphocytes therapy treats cancers at a large scale

Pollutant particles in the air trigger lung cancer in non-smokers

Tumor-derived factors stimulate effector trogocytosis and inhibit CAR T cells

Antibody escape less pronounced with BA.2.75 compared to BA.4/5

Discovery of antibodies that may eliminate the need for COVID vaccines

Climate change has increased the risk of bat-borne pathogen spillover

St. Baldrick's Scholar grant awarded to CU researcher for investigating new drug to treat infant leukemia

Gut microbes can also impact a person's neurological and emotional health, UTSW researcher says

Scientists reverse the effects of lysosomal storage disorders in patient cells and mice

Distribution of platinum after chemotherapy may help predict resistance to ovarian cancer treatment

Weill Cornell Medicine receives $61.9 million NIH grant to continue funding its Clinical and Translational Science Center

Potential HIV vaccine component leads to strong protection in primates

Early life exposure to antibiotics can have long-lasting effects on adult gut health

Can cod liver oil supplementation prevent COVID-19 and other acute respiratory infections?

The use of AlphaFold2-enabled molecular docking simulations to predict protein-ligand interactions for antibiotic drug discovery

Factors influencing patient’s perception during COVID-19 recovery

COVID-19’s long-term impact on orphanhood and caregiver loss

The evolution of humoral immune responses over the course of Epstein-Barr virus infection

Scientists identify genetic variants linked to an increased risk of developing Hodgkin lymphoma

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

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