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Researchers discover molecular basis for therapeutic actions of an African folk medicine

Researchers in the Department of Physiology & Biophysics at the University of California, Irvine School of Medicine have discovered the molecular basis for therapeutic actions of an African folk medicine used to treat a variety of illnesses and disorders including diabetes, pain, headaches, paralysis and epilepsy.

15 Nov 2018

New diabetes drugs linked to increased risk of lower-limb amputation and ketoacidosis

The use of a new class of drugs in the treatment of type 2 diabetes, so called SGLT2 inhibitors, are linked to a twofold increased risk for lower-limb amputation as well as diabetic ketoacidosis, a serious diabetes complication.

14 Nov 2018

Enable Injections enters into development agreements with UCB and Apellis Pharmaceuticals

Enable Injections, Inc., a patient-centric drug delivery combination product company developing advanced wearable devices for subcutaneous delivery of high-volume therapeutics, today announced it has entered into development agreements with Apellis Pharmaceuticals, and most recently, UCB.

14 Nov 2018

£500,000 grant could pave way for new antibiotic to battle against drug-resistant superbugs

A new antibiotic hailed as the "last line of defense" in the battle against drug-resistant superbugs such as MSRA and VRE is taking the next step in development thanks to a UK Government grant of almost £500,000.

14 Nov 2018

Breakthrough in the treatment of Restless Legs Syndrome

New research published in The Journal of Physiology presents a breakthrough in the treatment of Restless Legs Syndrome.

13 Nov 2018

Empowering the NHS through Industry Partnerships

An interview with Cara Afzal and Lee-Ann Farrell discussing the importance of industry partnerships with the NHS, and how Janssen are working to improve dementia care for Manchester and hematology services for Wales.

13 Nov 2018

Angiotensin receptor blockers improve sodium excretion in blacks

Drugs that inhibit a hormone that constricts blood vessels also help improve sodium excretion in blacks who hold onto too much sodium in the face of stress, investigators report.

13 Nov 2018

Suicidal patients with prescribed access to psychotropic drugs should be closely monitored

As prescriptions for psychotropic drugs increase, researchers at the University of Colorado Anschutz Medical Campus have found that prescribed access to anti-anxiety and anti-psychotic medications may make it easier for some patients to use the drugs in attempted suicides.

13 Nov 2018

Diabetes medication reduces risk of heart failure hospitalization

In the largest trial to date to assess cardiovascular outcomes for an important class of diabetes medications, researchers have found that dapagliflozin markedly reduced the risk of hospitalization for heart failure in a broad population of patients with diabetes.

12 Nov 2018

Fish oil and vitamin D pills no guard against cancer or serious heart trouble

A widely anticipated study has concluded that neither vitamin D nor fish oil supplements prevent cancer or serious heart-related problems in healthy older people, according to research presented Saturday at the American Heart Association Scientific Sessions. Researchers defined serious heart problems as the combined rate of heart attacks, stroke and heart-related deaths.

12 Nov 2018

Potential treatment for rare polio-like illness shows no signal of efficacy

Researchers have been searching for possible treatments for the polio-like illness causing paralysis in children, called acute flaccid myelitis.

9 Nov 2018

New oral drug reduces menstrual bleeding for women with common uterine tumors

A new oral drug significantly reduced menstrual bleeding for women with the most common gynecologic tumors in the United States - benign tumors that disproportionately affect African-Americans, an international clinical trial found.

9 Nov 2018

All infectious diseases likely to be seasonal

A new study has suggested that all infectious diseases are driven by seasonal elements, based on an analysis of 69 infectious diseases.

9 Nov 2018

Hypertonic saline shown to aid breathing in cystic fibrosis babies

The first-ever randomized controlled trial on babies with CF has found that treatment with inhaled hypertonic saline can improve breathing and lung health.

9 Nov 2018

Cholesterol-lowering drug reduces chance of having second heart problems or stroke

In a clinical trial involving 18,924 patients from 57 countries who had suffered a recent heart attack or threatened heart attack, researchers at the University of Colorado Anschutz Medical Campus and fellow scientists around the world have found that the cholesterol-lowering drug alirocumab reduced the chance of having additional heart problems or stroke.

8 Nov 2018

CDK2 protein plays key role in heart damage caused by doxorubicin, finds study

A new study by Washington State University researchers suggests that a protein called CDK2 plays a critical role in heart damage caused by doxorubicin, a commonly used chemotherapy drug.

8 Nov 2018

New study shows promise of innovative strategy against HER2-driven lung cancers

The HER2 gene is a well-known driver of breast cancer, where changes in this gene are found in about 1-in-5 cases of the disease. HER2 also contributes to about 3 percent of lung cancers, representing about 6,500 patients per year.

8 Nov 2018

Cannabinoids hold promise in treating children with epilepsy

In recent years, cannabinoids--the active chemicals in medical marijuana-- have been increasingly touted as a potential treatment for a range of neurological and psychiatric disorders. In a Developmental Medicine & Child Neurology review, investigators compare their efficacy with antiepileptic drugs for children with epilepsy.

7 Nov 2018

Study highlights need for interventions to improve statin use among older adults

In a British Journal of Clinical Pharmacology study of older adults prescribed statins, first-year nonadherence and discontinuation rates were high.

7 Nov 2018

New AI technology can potentially reduce bottlenecks in drug research

Researchers at the University of Waterloo have developed a new system that could significantly speed up the discovery of new drugs and reduce the need for costly and time-consuming laboratory tests.

7 Nov 2018