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Assumption that uterine blood redistributed into maternal circulation after delivery challenged

In an examination comparing the effects of two drugs on blood pressure, pulse, heart rate and cardiac output in women having elective delivery by cesarean section, an old assumption that uterine blood is redistributed into the maternal circulation after delivery was challenged, according to a study in the September issue of Anesthesiology.

22 Aug 2013

Antipsychotic drug not effective in treating delirium in critically ill patients

Haloperidol, an antipsychotic drug used in many hospitals to treat delirium in critically ill patients, is no more effective than placebo in reducing the number of days that critically ill patients spend either delirious or in a coma, according to new research published in The Lancet Respiratory Medicine.

22 Aug 2013

Pazopanib drug shows improved quality of life and safety in metastatic kidney cancer patients

Two oral targeted drugs approved for metastatic kidney cancer worked equally well, but one proved superior in tolerability, according to results of a large international clinical trial led by researchers at Dana-Farber Cancer Institute.

22 Aug 2013

Generic, therapeutic drug substitutions can help lower Medicare costs

Therapeutic drug substitutions have the potential to double or even triple annual cost savings compared with savings achieved with generic substitutions, according to O. Kenrik Duru and colleagues from the University of California, Los Angeles.

22 Aug 2013

Antipsychotic drugs for children with behavioral problems may put at risk for type 2 diabetes

Prescribing of "atypical" antipsychotic medications to children and young adults with behavioral problems or mood disorders may put them at unnecessary risk for type 2 diabetes, a Vanderbilt University Medical Center study shows.

22 Aug 2013

New antibody drug shows positive results for treating Crohn's disease, ulcerative colitis

Vedolizumab, a new intravenous antibody medication, has shown positive results for treating both Crohn's disease and ulcerative colitis, according to researchers at the University of California San Diego, School of Medicine. The findings, published in two papers, will appear in the August 22 issue of the New England Journal of Medicine (NEJM).

22 Aug 2013

Researchers report overall increase in use of tPA to dissolve clots blocking arteries

Use of the "clot-busting" drug tissue plasminogen activator to treat patients with strokes caused by a blockage of blood flow nearly doubled between 2003 and 2011.

22 Aug 2013

Scientists report possible basis for why food-restricted animals show susceptibility to drugs of abuse

Scientists today reported a possible basis for why food-restricted animals show increased susceptibility to drugs of abuse. This association has puzzled researchers since it was first observed more than three decades ago.

21 Aug 2013

New drug-delivery strategy for central vision loss

Johns Hopkins biomedical engineers have teamed up with clinicians to create a new drug-delivery strategy for a type of central vision loss caused by blood vessel growth at the back of the eye, where such growth should not occur.

20 Aug 2013

Chinese herbal medicine JSK protects against injury caused by damage to spinal cord blood vessels

A new study published in Restorative Neurology and Neuroscience demonstrates that Chinese herbal medicine Ji-Sui-Kang (JSK), given systemically for three weeks after injury in rats, improved locomotor function, reduced tissue damage, and preserved the structure of neural cells compared to control rats.

20 Aug 2013

Researchers find new strategy that has potential to change standard of care for DLBCL patients

Patients with an aggressive lymphoma that often relapses and kills within two years experienced a remission of their cancer and stayed disease-free as long as 28 months after taking a commercially-available drug that made chemotherapy more effective.

20 Aug 2013

Phase III trial evaluates impact of Wisconsin Ginseng on fatigue levels of cancer patients

Millions of cancer patients find themselves exhausted completing the most mundane of tasks, and extra sleep doesn't seem to help. Today, they find hope in a supplement that medical researchers have shown to be effective in boosting their energy levels: Wisconsin Ginseng.

20 Aug 2013

NCI-PCPT explores survival of men on finasteride drug

In the NCI-sponsored Prostate Cancer Prevention Trial (PCPT), initial findings from a decade ago showed that the drug finasteride significantly reduced the risk of prostate cancer, but among those who did develop prostate cancer, paradoxically, the drug was associated with an increased risk of high-grade disease.

20 Aug 2013

Evidence shows bevacizumab therapy improves survival in patients with glioblastoma

A new population-based study has found that patients with glioblastoma who died in 2010, after the Food and Drug Administration (FDA) approval of bevacizumab, had lived significantly longer than patients who died of the disease in 2008, prior to the conditional approval of the drug for the treatment of the deadly brain cancer. Bevacizumab is used to treat patients with certain cancers whose cancer has spread. The study appears in the journal Cancer.

20 Aug 2013

Tigercat and Velocity Pharmaceutical announce submission of IND application to FDA for VPD-737

Velocity Pharmaceutical Development, LLC ("VPD") and Tigercat Pharma, Inc., ("Tigercat") announced today the submission of an Investigational New Drug (IND) application to the US Food and Drug Administration (FDA) for VPD-737 for the treatment of chronic pruritus.

19 Aug 2013

FDA grants Orphan Drug Designation to Alnylam ALN-AT3 for treatment of hemophilia B

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced today that the U.S. Food & Drug Administration (FDA) has granted an Orphan Drug Designation to ALN-AT3 as a therapeutic for the treatment of hemophilia B.

17 Aug 2013

Older heart patients present unique challenges for determining optimal dosages of medications

Older heart patients present unique challenges for determining the optimal dosages of medications, so a new study from researchers at Duke Medicine offers some rare clarity about the use of drugs that are used to treat patients with heart attacks.

17 Aug 2013

Arrays of nanoscale sensors detect flaws in drugs and help improve production

MIT chemical engineers have discovered that arrays of billions of nanoscale sensors have unique properties that could help pharmaceutical companies produce drugs - especially those based on antibodies - more safely and efficiently.

17 Aug 2013

DLBCLs resistant to chemotherapy can be reprogrammed to respond using azacitidine

A phase I clinical trial showed diffuse, large B-cell lymphomas (DLBCLs) resistant to chemotherapy can be reprogrammed to respond to treatment using the drug azacitidine, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

17 Aug 2013

Kinetin stops the effects of Parkinson's disease on brain cells, say scientists

The active ingredient in an over-the-counter skin cream might do more than prevent wrinkles. Scientists have discovered that the drug, called kinetin, also slows or stops the effects of Parkinson's disease on brain cells.

16 Aug 2013

Pharmaceutical News

Assumption that uterine blood redistributed into maternal circulation after delivery challenged

Antipsychotic drug not effective in treating delirium in critically ill patients

Pazopanib drug shows improved quality of life and safety in metastatic kidney cancer patients

Generic, therapeutic drug substitutions can help lower Medicare costs

Antipsychotic drugs for children with behavioral problems may put at risk for type 2 diabetes

New antibody drug shows positive results for treating Crohn's disease, ulcerative colitis

Researchers report overall increase in use of tPA to dissolve clots blocking arteries

Scientists report possible basis for why food-restricted animals show susceptibility to drugs of abuse

New drug-delivery strategy for central vision loss

Chinese herbal medicine JSK protects against injury caused by damage to spinal cord blood vessels

Researchers find new strategy that has potential to change standard of care for DLBCL patients

Phase III trial evaluates impact of Wisconsin Ginseng on fatigue levels of cancer patients

NCI-PCPT explores survival of men on finasteride drug

Evidence shows bevacizumab therapy improves survival in patients with glioblastoma

Tigercat and Velocity Pharmaceutical announce submission of IND application to FDA for VPD-737

FDA grants Orphan Drug Designation to Alnylam ALN-AT3 for treatment of hemophilia B

Older heart patients present unique challenges for determining optimal dosages of medications

Arrays of nanoscale sensors detect flaws in drugs and help improve production

DLBCLs resistant to chemotherapy can be reprogrammed to respond using azacitidine

Kinetin stops the effects of Parkinson's disease on brain cells, say scientists

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

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