CRISPR News and Research

Latest CRISPR News and Research

Understanding the epigenetic regulation of hepatic stellate cells in NAFLD

Non-alcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, affecting approximately 38% of the global population from 2016 to 2019.

25 Jul 2024

Creating the first genetically susceptible mice for late-onset Alzheimer's

Mice don't get Alzheimer's - and while that's good news for mice, it's a big problem for biomedical researchers seeking to understand the disease and test new treatments.

24 Jul 2024

Multi-signal processing guide RNAs: A new frontier in gene regulation

Guides typically assist tourists with directions, but the experience could be greatly enhanced if they offered personalized services tailored to individual interests.

22 Jul 2024

USC scientists transform B cells into cancer and HIV destroyers

USC scientists have discovered a way to turn the body's B cells into tiny surveillance machines and antibody factories that can pump out specially designed antibodies to destroy cancer cells or HIV, two of medicine's most formidable foes.

22 Jul 2024

CD5 knockout using CRISPR boosts CAR T cell therapy efficacy

The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, a protein found on the surface of T cells, according to a preclinical study from investigators at the University of Pennsylvania's Perelman School of Medicine and Abramson Cancer Center.

19 Jul 2024

Common blood thinner can be repurposed as an inexpensive antidote for cobra venom

Scientists at the University of Sydney and Liverpool School of Tropical Medicine have made a remarkable discovery: a commonly used blood thinner, heparin, can be repurposed as an inexpensive antidote for cobra venom.

18 Jul 2024

Distinct signaling pathway drives the transformation of epithelial cells into aggressive tumors

A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells.

18 Jul 2024

CU Boulder research uncovers role of endogenous retroviruses in cancer

Peek inside the human genome and, among the 20,000 or so genes that serve as building blocks of life, you'll also find flecks of DNA left behind by viruses that infected primate ancestors tens of millions of years ago.

18 Jul 2024

Novel method enables RNA detection with Cas12 nucleases

CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics.

17 Jul 2024

Harnessing cell's natural delivery system for targeted drug delivery

Each cell in the body has its own unique delivery system that scientists are working on harnessing to move revolutionary biological drugs - molecules like proteins, RNA and combinations of the two - to specific diseased parts of the body.

17 Jul 2024

One-time prime editing targets common genetic cause of cystic fibrosis

Researchers optimized prime editing for the efficient correction of the cystic fibrosis transmembrane conductance regulator F508del mutation in human airway epithelial cells, achieving high correction efficiencies and functional restoration with minimal off-target effects.

15 Jul 2024

Gene editing silences mutant microRNA, restores hearing in adult mice

Researchers have used gene editing to restore hearing in adult mice with a type of inherited hearing loss. They showed that shutting down a damaged copy of a gene called a microRNA (miRNA) enabled the animals to regain hearing. The approach by a research team supported by the National Institutes of Health (NIH), reported in Science Translational Medicine, may eventually lead to potential treatments for inherited hearing loss in people.

13 Jul 2024

Enzymatic RNA synthesis paves the way for sustainable therapeutics

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and amyloidosis.

12 Jul 2024

Prime editing offers promising path to permanent treatment for cystic fibrosis

Cystic fibrosis is one of the most common genetic disorders, causing thick mucus build-up in the lungs and other parts of the body, breathing problems, and infection.

11 Jul 2024

New gene editing technique offers hope for millions

A team led by Mass Eye and Ear researchers has demonstrated for the first time a successful restoration of hearing through a novel, in vivo genome editing approach in an adult mouse model with a form of inherited deafness caused by mutations in microRNA.

11 Jul 2024