Colon Cancer

Every year, about one million new cases of colon cancer are diagnosed worldwide. About 150,000 new cases are detected each year in the United States. Over a lifetime, about 1 in 19 people develop colon cancer and nearly 50,000 people are expected to die from it in the U.S. this year.

What Causes Colorectal Cancer?

Cancer occurs when a normal cell divides and multiples uncontrollably. Normally cells are regulated in their growth, maturity, division and death by the DNA present in their nucleus. With damage to the DNA the cells may become rogue and multiply uncontrollably to give rise to tumors.

Colorectal Cancer Prevention

Colorectal Cancer Management

Colorectal Cancer Prognosis

Colorectal Cancer Symptoms

What is Colorectal Cancer?

Colorectal Cancer Diagnosis

Latest Colon Cancer News and Research

Immunotherapy plus chemotherapy improves outcomes in stage III dMMR colon cancer

A new study from researchers at the Alliance for Clinical Trials in Oncology (Alliance) shows that patients with stage III colon cancer with deficient deoxyribonucleic acid (DNA) mismatch repair (dMMR) had significantly better outcomes when the immunotherapy drug atezolizumab (Tecentriq®) was added to standard chemotherapy after surgery.

25 Mar 2026

Chronic inflammation leaves epigenetic scars that increase future cancer risk

Chronic inflammation can raise a person's risk of cancer, and a new study reveals key details about how that might happen in the gut and points to better ways to identify and reduce risk.

25 Mar 2026

Weaning reshapes gut microbes to strengthen lifelong immune defenses

According to a team of researchers at Baylor College of Medicine, Tongji University and collaborating institutions, weaning or switching from milk to solid food in early life doesn't just change what babies eat, it helps reprogram the gut's immune defenses to mount faster and stronger responses that can last into adulthood.

19 Mar 2026

Tumor debulking fails to improve survival in colorectal cancer

Research shows tumor debulking in advanced colorectal cancer does not enhance survival outcomes and may increase adverse effects, questioning its efficacy.

19 Mar 2026

New nanoparticle therapy overcomes T cell exhaustion in solid tumors

Engineers at the University of Pennsylvania have developed a new type of lipid nanoparticle (LNP) that could one day serve as a universal immunotherapy for cancers that form solid tumors, including common variants such as cancers of the breast, liver and colon.

18 Mar 2026

Blocking fructose metabolism may improve brain tumor immunotherapy response

Northwestern Medicine scientists have discovered that specialized immune cells within the glioblastoma tumor metabolize fructose to suppress immune responses and promote tumor growth, reports a study published on March 17 in the Proceedings of the National Academy of Sciences.

17 Mar 2026

New AI system reduces pathologist workload while maintaining diagnostic accuracy

Artificial intelligence could make cancer diagnosis safer and fairer by learning when to defer to human pathologists without overloading them, according to researchers from the University of Surrey and Monash University.

13 Mar 2026

New research initiative aims to predict and prevent diseases before they start

What if doctors could tell you a disease was coming years before you felt a single symptom-and stop it in its tracks? That is the goal of a sweeping new research initiative launched by the Icahn School of Medicine at Mount Sinai in collaboration with the Uniformed Services University of the Health Sciences (USU) and the Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF).

2 Mar 2026

Dysplasia grade predicts colorectal cancer risk in people with IBD

People with inflammatory bowel disease (IBD) and precancerous colorectal lesions are much more likely to develop colorectal cancer, a new study shows.

16 Feb 2026

Nanovaccine design boosts immune attack on HPV tumors

Throughout the past decade, Northwestern University scientists have uncovered a striking principle of vaccine design: Performance depends not only on vaccine components but also on vaccine structure.

11 Feb 2026

Rural cancer patients benefit from local surgical care

Adults living in rural communities often travel long distances when seeking treatment for cancer, but distant travel may not always be necessary to receive high-quality surgical care, according to a new analysis published in the Journal of the American College of Surgeons (JACS).

11 Feb 2026

End of enhanced Obamacare subsidies puts tribal health lifeline at risk

Leonard Bighorn said his mother tried for two years to get help for severe stomach pain through the limited health services available near her home on the Fort Peck Reservation in northeastern Montana.

11 Feb 2026

New genetic model reveals role of keratin 8 in colorectal cancer development

Researchers at Åbo Akademi University have identified a new molecular change in patients with colorectal cancer and developed a genetic disease model that forms tumors in the large intestine, resembling those seen in patients.

10 Feb 2026

RNA micelles enable targeted chemotherapy without immune toxicity

A new study in mice hints at the potential to use tiny particles made with RNA molecules to deliver chemotherapy drugs and other therapies directly to tumors, killing cancer cells without generating an immune response or toxicity-related side effects.

7 Feb 2026

Lifetime heavy drinking sharply raises colorectal cancer risk, major US study finds

Lifetime alcohol intake, not just recent drinking, is associated with colorectal cancer risk in older adults followed in the PLCO Cancer Screening Trial. Heavy and consistent long-term drinking was linked to higher colorectal cancer risk, while alcohol cessation was associated with lower odds of early, nonadvanced adenomas.

28 Jan 2026

AI tool predicts metastatic risk in multiple cancers

Why do some tumors spread while others remain localized? The mechanisms governing the metastatic potential of tumor cells remain largely unknown — yet understanding this is crucial for optimizing patient care.

22 Jan 2026

Blood test identifies colon cancer patients who benefit from anti-inflammatory medication

A blood test could help doctors decide which patients with colon cancer should receive anti-inflammatory medication along with chemotherapy after surgery, according to new study in JAMA Oncology.

15 Dec 2025

White bread vs wholegrain: which one is actually better for your health?

This review dispels common myths about white and wholegrain bread by examining their composition processing and health effects. It concludes that while wholegrain breads offer added benefits white bread remains a safe affordable and nutritionally meaningful staple when fortified.

11 Dec 2025

Integrating AI into colon cancer diagnosis improves the speed and accuracy of detection

A recent study reveals that integrating Artificial Intelligence (AI) into colon cancer diagnosis over the past five years has significantly improved the speed and accuracy of the detection of the deadly disease.

8 Dec 2025

A personalized approach to treating pancreatic cancer

It's not surprising that pancreatic cancer is often referred to as a silent killer. With few early symptoms and an aggressive nature, it has one of the lowest survival rates of all cancers.

3 Dec 2025