Crohn's Disease News and Research

Latest Crohn's Disease News and Research

New diagnostic imaging tool measures naturally occurring enzymes in the gastrointestinal tract

A healthy person has a general balance of good and bad bacteria. But that balance is thrown off when someone gets sick.

5 Feb 2021

Crafoord Laureate uncovered a new group of rare autoinflammatory diseases

Dan Kastner, USA, has described an entirely new group of rare autoinflammatory diseases. His discoveries have brought new knowledge and led to the development of effective treatments.

1 Feb 2021

DSMB recommends continuation of Phase 2/3 study of opaganib for severe COVID-19

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced that the independent Data Safety Monitoring Board (DSMB) for the global Phase 2/3 study of opaganib in patients with severe COVID-19, unanimously recommended to continue the study following a pre-scheduled futility review of unblinded efficacy data from the first 135 patients treated in the study and safety data from the first 175 patients.

30 Jan 2021

New partnership to develop test for predicting disease course in pediatric Crohn's patients

The Crohn's & Colitis Foundation, the leading non-profit organization focused on both research and patient support for inflammatory bowel disease (IBD), has entered into a partnership with LifeArc, an independent medical research charity that advances translation of early science into health care treatments or diagnostics, to potentially develop the first clinical lab test to predict disease course in pediatric patients with Crohn's disease and response to treatment.

25 Jan 2021

CoQ10 supplement could be a valuable complementary therapeutic option for various diseases

A study led by scientists from the University of Granada (UGR) has found that a supplement of Coenzyme Q10 (CoQ10), an essential molecule for life that is synthesized in the cells of our organs and tissues and is also acquired through diet, could constitute a valuable complementary therapeutic option in the treatment of certain mitochondrial diseases, colon cancer, thyroid carcinoma, and Crohn’s disease.

18 Jan 2021

RedHill Biopharma: RHB-204 receives FDA Fast Track designation for treatment of NTM disease

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced that RHB-204 has been granted Fast Track designation by the U.S. Food and Drug Administration for its development as a potential first-line, stand-alone, oral treatment of pulmonary nontuberculous mycobacteria (NTM) disease caused by Mycobacterium avium Complex (MAC) - a rare disease for which there is no FDA-approved first-line therapy.

6 Jan 2021

P2 COVID-19 study shows no material safety differences between opaganib and control arms

Preliminary data from the non-powered U.S. Phase 2 study of 40 hospitalized patients shows that orally-administered opaganib was safe, with no material safety differences between opaganib and control arms.

4 Jan 2021

Polygenic risk scores from multi-population data could improve IBD predictions

Using genetic data from nearly 30,000 people, Mount Sinai researchers have built risk scores from a combination of datasets representing distinct ancestral populations that improve prediction of risk for inflammatory bowel diseases (IBD) including Crohn's disease and ulcerative colitis. The study was published in Gastroenterology on December 24.

24 Dec 2020

Phase 2/3 COVID-19 study evaluates safety, potential identification of preliminary efficacy signals

Top-line data from the 270-patient global Phase 2/3 COVID-19 study expected Q1/2021. Top-line data from the 40-patient U.S. Phase 2 study of opaganib in severe COVID-19 expected in the coming days; this non-powered study was designed to evaluate safety and potential identification of preliminary efficacy signals in support of the global Phase 2/3 study of opaganib.

23 Dec 2020

Researchers demonstrate potential preventive treatment for Crohn's disease

A potential preventive treatment for Crohn's disease, a form of inflammatory bowel disease, has been demonstrated in a mouse model and using immune-reactive T cells from patients with Crohn's disease.

21 Dec 2020

RedHill Biopharma announces promising preliminary results from opaganib study

TEL AVIV, Israel and RALEIGH, NC, December 15, 2020, RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced promising preliminary results from a preclinical study with opaganib.

15 Dec 2020

Study uncovers genetic risks of Takayasu arteritis

In a paper published today in the American Journal of Human Genetics, a group of international collaborators led by researchers from the University of Pittsburgh School of Medicine identified new genetic associations that can predict individual susceptibility to a rare inflammatory disease called Takayasu arteritis.

11 Dec 2020

Researchers pinpoint key factors to ensure successful fecal microbiota transplants

Could number two be number one when it comes to combating recurrent Clostridium difficile (CDI) infections?Using genetic material analysis and machine learning, UBC researchers have pinpointed several key factors to ensure successful fecal microbiota transplants (FMT), which have proven successful in treating bacterial infections in the gut including illnesses like C. difficile, Crohn's Disease, Colitis and even obesity, explains lead author Negin Kazemian.

10 Dec 2020

Steroids used to treat inflammatory disease increases risk of cardiovascular disease

Researchers have found that prescribed low doses of steroids, often to combat inflammatory diseases, are at an increased risk of cardiovascular diseases.

3 Dec 2020

Penn State researcher to study how vitamin D regulates host immunity to viral infection

Funding from the National Institutes of Health will enable a Penn State researcher to study whether vitamin D supplementation could help people ward off or reduce symptoms caused by COVID-19.

24 Nov 2020

Workers who lost jobs due to COVID may need help getting coverage this fall

Michelina Moen lost her job and health insurance in April. Only weeks earlier she had begun to feel ill and not her usual energetic self — in what she describes as a textbook case of "really bad timing."

12 Nov 2020

Study identifies genetic risk for fatal blood clots in IBD patients

Blood clots are the biggest cause of death in patients with inflammatory bowel disease (IBD) ─ ulcerative colitis or Crohn's disease. In a retrospective study recently published in the journal Gastroenterology, Cedars-Sinai investigators found that a combination of rare and common genetic variants in some IBD patients significantly increased their risk of developing clot-causing thromboembolic diseases.

11 Nov 2020

Researchers launch clinical trial to assess therapeutic drug monitoring for patients with inflammatory diseases

New research presented at ACR Convergence, the American College Rheumatology's annual meeting, showed that patients with rheumatic diseases whose infliximab treatment was individually assessed and adjusted with a new strategy called therapeutic drug monitoring did not achieve remission at higher rates compared to those who received standard care.

8 Nov 2020

New IBD safety registry established to support the completion of post-marketing safety requirements

The Pediatric IBD Foundation, ImproveCareNow, and the Critical Path Institute (C-Path) are proud to announce a collaboration establishing the Children's Registry for the Advancement of Therapeutics (CREATE™).

6 Nov 2020

Study suggests a role for the hypothalamus in genetic susceptibility to IBD

Using sophisticated 3D genomic mapping and integrating with public data resulting from genome-wide association studies, researchers at Children's Hospital of Philadelphia have found significant genetic correlations between inflammatory bowel disease and stress and depression.

29 Oct 2020

Crohn's Disease News and Research

Latest Crohn's Disease News and Research

New diagnostic imaging tool measures naturally occurring enzymes in the gastrointestinal tract

Crafoord Laureate uncovered a new group of rare autoinflammatory diseases

DSMB recommends continuation of Phase 2/3 study of opaganib for severe COVID-19

New partnership to develop test for predicting disease course in pediatric Crohn's patients

CoQ10 supplement could be a valuable complementary therapeutic option for various diseases

RedHill Biopharma: RHB-204 receives FDA Fast Track designation for treatment of NTM disease

P2 COVID-19 study shows no material safety differences between opaganib and control arms

Polygenic risk scores from multi-population data could improve IBD predictions

Phase 2/3 COVID-19 study evaluates safety, potential identification of preliminary efficacy signals

Researchers demonstrate potential preventive treatment for Crohn's disease

RedHill Biopharma announces promising preliminary results from opaganib study

Study uncovers genetic risks of Takayasu arteritis

Researchers pinpoint key factors to ensure successful fecal microbiota transplants

Steroids used to treat inflammatory disease increases risk of cardiovascular disease

Penn State researcher to study how vitamin D regulates host immunity to viral infection

Workers who lost jobs due to COVID may need help getting coverage this fall

Study identifies genetic risk for fatal blood clots in IBD patients

Researchers launch clinical trial to assess therapeutic drug monitoring for patients with inflammatory diseases

New IBD safety registry established to support the completion of post-marketing safety requirements

Study suggests a role for the hypothalamus in genetic susceptibility to IBD

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Crohn's Disease News and Research

Latest Crohn's Disease News and Research

Leveraging the Radian ASAP in standard casework

A journey through science, software, and innovation: Insights from the Bruker software team

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

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