Crohn's Disease

Crohn’s disease is a chronic inflammatory disease of the bowel affecting at least 115,000 people in the UK. The condition usually develops in teenagers and young adults, but can be diagnosed at any age and is equally common in men and women.

What is Crohn's Disease?

Crohn’s disease is a disease that leads to severe inflammation of the lining of the digestive system.

Intestinal Mycoplasma and Crohn's Disease

Crohn's Disease Symptoms

Crohn's Disease Cause

History of Crohn's Disease

Crohn's Disease Diagnosis

Crohn's Disease Treatment

Crohn's Disease Complications

Latest Crohn's Disease News and Research

Immune-regulating molecule may offer new treatment approach for IBD patients

Mayo Clinic researchers have identified an immune-regulating molecule that may help explain why some patients with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, do not respond to commonly used therapies.

13 May 2026

Intestinal stem cells identified as active defenders against Salmonella infection

Researchers from the Hebrew University of Jerusalem and the Weizmann Institute of Science have identified a previously unrecognized defense mechanism in the intestine, showing that intestinal stem cells can actively respond to Salmonella infection and help protect the gut from bacterial invasion.

12 May 2026

Study highlights breakthrough in overcoming diminishing returns of sequential IBD therapies

For patients with Crohn's disease or ulcerative colitis who have exhausted other treatment options, a new combination therapy is showing results that offer hope for one of medicine's most treatment-resistant populations, according to findings from two studies to be presented today at Digestive Disease Week® (DDW) 2026.

5 May 2026

Repurposed cancer drugs offer potential breakthrough for Crohn’s disease treatment

University of Houston biologists have contributed to a potential breakthrough in treating Crohn's disease by shifting the clinical focus from symptom management to addressing a primary underlying cause of the condition.

27 Apr 2026

EV-RNAs show promise for IBD diagnosis and treatment

A research team led by Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, has published a comprehensive review in ExRNA that sorts out the diverse roles of extracellular vesicle-associated RNAs (EV-RNAs) in the development and progression of inflammatory bowel disease (IBD).

10 Apr 2026

Scientists use living muscle to reanimate paralyzed organs

What if a technology could reanimate parts of the body that have lost their connection to the brain - like a bladder that can no longer empty due to a spinal cord injury, or intestines that can't push food forward due to Crohn's disease? What if this technology could also send sensations such as hunger or touch back to the brain?

31 Mar 2026

Guselkumab shows minor added benefit for specific Crohn's disease patients

The human monoclonal antibody guselkumab has been approved for certain adults with moderately to severely active ulcerative colitis since April 2025.

27 Mar 2026

Weaning reshapes gut microbes to strengthen lifelong immune defenses

According to a team of researchers at Baylor College of Medicine, Tongji University and collaborating institutions, weaning or switching from milk to solid food in early life doesn't just change what babies eat, it helps reprogram the gut's immune defenses to mount faster and stronger responses that can last into adulthood.

19 Mar 2026

Researchers identify cellular drivers of gut scarring in Crohn’s disease

As inflamed regions of the gut form scar tissue, the space within the gut lumen becomes smaller and more restricted, leading to symptoms of gut obstruction.

16 Mar 2026

Gut microbiome-produced nicotinic acid protects colon tissue from injury

The gut microbiome-the trillions of bacteria and other microbes that inhabit the gastrointestinal tract-drives a process vital for protecting the colon against tissue injury, according to the findings of a study co-led by Cedars-Sinai Health Sciences University investigators.

10 Mar 2026

New collaboration explores familial inflammatory bowel disease in Saudi Arabia

Mount Sinai and King Saud University Medical City in Riyadh, Saudi Arabia, today announced a three-year collaboration aimed at better understanding why inflammatory bowel disease (IBD) runs in some Saudi families, and how that knowledge can lead to risk ascertainment, earlier diagnosis and more personalized treatment options.

3 Mar 2026

New research initiative aims to predict and prevent diseases before they start

What if doctors could tell you a disease was coming years before you felt a single symptom-and stop it in its tracks? That is the goal of a sweeping new research initiative launched by the Icahn School of Medicine at Mount Sinai in collaboration with the Uniformed Services University of the Health Sciences (USU) and the Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF).

2 Mar 2026

Forecasting disease intensity through genomic risk

Approximately 60,000 Danes live with chronic inflammatory bowel disease. Some experience limited discomfort, while others go through a debilitating disease course involving surgery and a stoma. Add to this the fear of leaving home due to urgent toilet needs.

2 Mar 2026

Dysplasia grade predicts colorectal cancer risk in people with IBD

People with inflammatory bowel disease (IBD) and precancerous colorectal lesions are much more likely to develop colorectal cancer, a new study shows.

16 Feb 2026

Distinct microbial signature identified in pediatric Crohn's disease

NYU researchers have found a "microbial signature" of pediatric Crohn's disease that differs from the makeup of gut bacteria in children with other gastrointestinal conditions, with Crohn's patients harboring more pro-inflammatory bacteria and less protective bacteria.

12 Feb 2026

Time-restricted feeding reduces disease activity and inflammation in Crohn's patients

A new randomized controlled study funded by the Crohn's & Colitis Foundation found that time-restricted feeding-a form of intermittent fasting-significantly reduced symptomatic disease activity and systematic inflammation in adults with Crohn's disease and overweight or obesity.

9 Feb 2026

Research uncovers alternative inflammatory pathway in rheumatoid arthritis treatment

The class of anti-inflammatory drugs known as TNF-inhibitors has brought relief to many sufferers of rheumatoid arthritis, but they don't work for up to 4 of every 10 patients.

30 Jan 2026

Discovery explains why people with IBD have higher risk of colorectal cancer

A chain of immune reactions in the gut—driven by a key signaling protein and a surge of white blood cells from the bone marrow—may help explain why people with inflammatory bowel disease (IBD) have a higher risk of colorectal cancer, according to a preclinical study by Weill Cornell Medicine investigators.

22 Jan 2026

Pregnant individuals with inflammatory bowel disease show heightened vaginal inflammation

Pregnant individuals with inflammatory bowel disease (IBD) have higher levels of pro-inflammatory immune molecules, known as cytokines, in their vaginal mucosa than their healthy counterparts, according to a new study published January 14, 2026 in the open-access journal PLOS One by Ana Maldonado-Contreras of University of Massachusetts Chan Medical School, U.S., and colleagues.

14 Jan 2026