Diarrhea

Diarrhea is loose, watery stools. A person with diarrhea typically passes stool more than three times a day. People with diarrhea may pass more than a quart of stool a day.

What is Diarrhea?

The term diarrhea (also spelled diarrhoea) refers to passage of loose, watery stools. The usual frequency of passing loose stools or watery stools in cases of diarrhea is at least three or more times a day.

Diarrhea Epidemiology

Acute Diarrhea

Stomach Cramps and Diarrhea: Distinguishing Between Common and Serious Causes

Chronic Diarrhea

Diarrhea Symptoms

Diarrhea Causes

Diarrhea in Children

Diarrhea Treatment

Diarrhea Prevention

Latest Diarrhea News and Research

Combination therapy shows promise for leptomeningeal metastasis in breast cancer

Patients with leptomeningeal metastasis (LM) have historically had few treatment options. Now, researchers from The University of Texas MD Anderson Cancer Center have found a combination of targeted therapies, tucatinib and trastuzumab, plus the chemotherapy drug, capecitabine, may improve symptoms and extend survival in some breast cancer patients with LM.

18 Mar 2026

New risk models improve food safety guidelines for pregnant individuals

Listeria is the third-leading cause of death among bacterial foodborne pathogens in the U.S. and pregnant individuals bear a disproportionate share of that burden.

17 Mar 2026

Childhood stress may lead to digestive issues later in life

Early life stress may lead to digestive issues later in life, driven by changes in the gut and sympathetic nervous systems, according to a new study published in the journal Gastroenterology.

16 Mar 2026

Doctors warn of a deadly complication from measles outbreaks

The first sign came when Deepanwita Dasgupta was 5 and started stumbling more while playing at her home in Bangalore in southern India.

13 Mar 2026

Swapping red meat for plant-based meat rapidly lowers a key heart risk metabolite, trial finds

A randomized crossover trial found that replacing red meat patties with processed plant-based meat alternatives for six days significantly lowered circulating trimethylamine N-oxide (TMAO), a gut-derived metabolite linked to cardiovascular risk. The plant-based phase also produced modest reductions in cholesterol markers but slightly increased weight and NT-proBNP, possibly due to higher sodium intake.

12 Mar 2026

Engineered lettuce may turn injectable GLP-1 therapies into oral pills

Few drugs have entered mainstream awareness as quickly or as dramatically as glucagon-like peptide-1, or GLP-1 receptor agonists. Initially approved by the FDA for the treatment of type 2 diabetes, they have since also transformed the therapeutic landscape of obesity and weight management.

6 Mar 2026

Tufts researchers identify new vulnerabilities to combat persistent C. diff infections

Affecting roughly half a million Americans each year, bacterial infections caused by Clostridioides difficile—commonly known as C. diff—are a serious and persistent problem for patients and hospitals alike.

5 Mar 2026

Why measles remains one of the most contagious viral diseases worldwide

This review synthesizes current evidence on measles virus biology, immune responses, complications, treatments, and prevention strategies. It highlights how measles can suppress immune memory, increasing susceptibility to other infections, and underscores vaccination as the most effective control measure.

4 Mar 2026

Experts identify safest and most effective diets for IBS management

This review in Nutrients evaluates the scientific evidence, clinical effectiveness, and safety of major dietary strategies for irritable bowel syndrome, including traditional advice, low-FODMAP, gluten-free, Mediterranean, and starch- and sucrose-reduced diets. It concludes that while the low-FODMAP diet has the strongest short-term evidence, no single approach fits all patients, and dietitian-led personalization is essential.

2 Mar 2026

Routine terminal ileum intubation and biopsy: A standard practice for colonoscopy completion

Terminal ileum intubation is considered the completion step of colonoscopy and is usually performed to assess the ileum.

27 Feb 2026

Distinct gut toxicity patterns emerge with targeted cancer treatments

A new paper was published in Volume 13 of Oncoscience on February 6, 2026, titled "Gastrointestinal toxicity of targeted cancer therapies in the United States: Clinicopathologic patterns, FDA safety frameworks, and implications for national patient protection."

20 Feb 2026

How GLP-1 drugs affect the body beyond weight loss and glucose control

This review evaluates the safety profile of glucagon-like peptide-1 receptor agonists and related incretin therapies used for obesity and type 2 diabetes. It highlights common gastrointestinal effects, rare but debated risks, and areas where further long-term safety data are still needed.

18 Feb 2026

Ozempic users continue treatment when weight loss works despite side effects

A study on Ozempic for weight loss reveals user satisfaction is driven by efficacy, despite common gastrointestinal side effects impacting treatment adherence.

13 Feb 2026

Bat viruses in Indochina Peninsula reveal viral diversity, PEDV origins, and spillover risks

Bats, critical reservoirs of viruses with significant cross-species spillover risks, have long been understudied in the Indochina Peninsula.

2 Feb 2026

Two-thirds of adolescent IBS sufferers outgrow the condition by adulthood

Two out of three adolescents with irritable bowel syndrome (IBS) start adulthood without the disease, according to a long-term study that followed more than 2,500 individuals.

2 Feb 2026

Poop pills could help cancer patients respond to immunotherapy while reducing toxic side effects

Fecal microbiota transplants (FMT), can dramatically improve cancer treatment, suggest two groundbreaking studies published in the prestigious Nature Medicine journal.

28 Jan 2026

Unraveling liver injury mechanisms in familial hypobetalipoproteinemia

Familial Hypobetalipoproteinemia (FHBL), caused by variants in the apolipoprotein B (APOB) gene, is a rare autosomal co-dominant monogenic disorder characterized by lifelong low plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and APOB.

24 Jan 2026

Genetic study links vitamin B1 metabolism to gut motility and IBS risk

Research links thiamine metabolism to gut motility, identifying genetic markers that could lead to new therapies for IBS and related digestive disorders.

23 Jan 2026

NuSHs can be a promising therapeutic strategy for preventing MASH-related hepatocellular carcinoma

Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH), represent the most common chronic liver diseases in Western populations, driven largely by obesity and insulin resistance.

21 Jan 2026

PRoRota-project aims to fight diarrhea in children using probiotics, hygiene, and models

The PRoRota-project will use probiotics, improved education in hygiene and advanced mathematical models to prevent children from dying of diarrhea in low and middle-income countries.

16 Jan 2026