Gene News and Research

Latest Gene News and Research

New drug regimen is safe and effective in children with cystic fibrosis

An international, open-label Phase 3 study, co-led by Susanna McColley, MD, from Ann & Robert H. Lurie Children's Hospital of Chicago, found that a regimen of three drugs (elexacaftor/tezacaftor/ivacaftor) that targets the genetic cause of cystic fibrosis was safe and effective in 6-11-year-olds with at least one copy of F508del mutation in the CFTR gene, which is estimated to represent almost 90 percent of the cystic fibrosis population in the United States.

19 Mar 2021

Scientists use clinical data to study the molecular groups of atypical teratoid rhabdoid tumor

Atypical teratoid rhabdoid tumor (ATRT) is a rare brain tumor that predominantly occurs in young children. Scientists at St. Jude Children's Research Hospital used data from two clinical trials to study the molecular groups of ATRT and correlate them with clinical outcomes.

19 Mar 2021

Alliance for Cancer Gene Therapy provides new opportunity to develop cancer cell and gene therapies

Alliance for Cancer Gene Therapy wants to change the C-word from Cancer to Cure -- building on the life changing success of CAR-T therapies for blood cancers, the organization is now focused on the urgent need to translate this success into therapies to fight more types of cancer, such as solid tumor cancers.

19 Mar 2021

Study reveals biomarkers for the prognosis of gastric adenocarcinoma

Low plasma levels of protein TGFB1 and polymorphisms in gene TGFB1 act as biomarkers for the prognosis of gastric adenocarcinoma, according to a study led by the University Complutense of Madrid.

18 Mar 2021

Weight loss induced by diet and bariatric surgery has different impact on mitochondria in fat tissue

Dieting impairs the energy-producing machinery of fat tissue, potentially resulting in weight regain. In contrast, as indicated by a recently completed European study coordinated by the University of Helsinki, weight loss surgery gives a boost to mitochondria, improving the gene expression of these cellular engines.

18 Mar 2021

Study explores how CAR T immunotherapy could be used to treat solid tumors

A study recently published in the journal Science looked into how CAR T immunotherapy could be used to treat solid tumors in addition to leukemias. The programming of CAR T cells opens avenues for applying cell therapies to, for example, breast cancer or ovarian cancer in the future.

18 Mar 2021

Molecule produced by the immune system can reduce potency of antibiotics

Research from the University of Kent's School of Biosciences has revealed that a molecule produced by the human immune system can severely diminish the potency of certain antibiotics.

18 Mar 2021

Novel cancer-fighting gene therapy enters phase I clinical trial

Researchers from the MDC and Charité have developed a new gene therapy based around a special T-cell receptor that helps the immune system effectively recognize and fight cancer cells.

18 Mar 2021

New study maps SARS-CoV-2 and host protein interactions in detail

A new study has developed a systemic map detailing the mechanistic interactions and disruptions between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its host cell.

18 Mar 2021

New Alzheimer's model may help test novel treatments

Our knowledge of Alzheimer's disease has grown rapidly in the past few decades but it has proven difficult to translate fundamental discoveries about the disease into new treatments.

18 Mar 2021

Study confirms that higher level of maternal folate increases the child’s birthweight

Imagine that you are going to conduct research on how different factors affect a child in the womb. Bad habits such as smoking, drinking alcohol or poor eating habits are factors that may affect the child.

18 Mar 2021

GMP-Ready Helper Plasmids for AAV Production

Manufactured in dedicated clean-rooms with mandated changeovers before new production cycles - AMSBIO introduces new pHelper-Kan plasmid DNA optimized for Adeno-Associated Virus (AAV) manufacturing.

18 Mar 2021

Gene expression of viral entry factors may explain the differences of COVID-19 severity

A new study uncovers which cell types can be infected by SARS-CoV-2 due to their viral entry factors. The study also suggests that increased gene expression of these viral entry factors in some individuals partially explains the differences of COVID-19 severity reported in relation to age, gender and smoking status.

18 Mar 2021

Long noncoding RNA plays a vital role in mobilizing immune response after organ transplantation

A long noncoding RNA whose function was previously unknown turns out to play a vital role in mobilizing the immune response following a bone marrow transplant or solid organ transplantation.

17 Mar 2021

A complete genetic and clinical analysis of individuals with SCN2A-related disorders

Researchers from Children's Hospital of Philadelphia affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) have compiled a complete genetic and clinical analysis of more than 400 individuals with SCN2A-related disorder, which has been linked to a variety of neurodevelopmental disorders, including epilepsy and autism.

17 Mar 2021

Beneficial effects of gene therapy can be seen in SCID-X1 patients decades after treatment

An international collaboration between Great Ormond Street Hospital, the UCL GOS Institute for Child Health and Harvard Medical School has shown that the beneficial effects of gene therapy can be seen decades after the transplanted blood stem cells has been cleared by the body.

17 Mar 2021

Researchers explore potential role of TARM1 protein in pathogenesis of rheumatoid arthritis

TARM1 is a receptor protein whose role in the functioning of the immune system is unknown. In a new study, scientists from Japan have explored the potential role of TARM1 in the pathogenesis of rheumatoid arthritis by analyzing mouse models.

17 Mar 2021

Insights into elusive protein complex can help find novel treatments for chromosomal disorders

The cells in our body are constantly fighting off the threat of cancer by repairing damaged DNA. In a new study, scientists from Tokyo University of Science investigate the structure of an elusive protein complex that plays a key role in the activation of the "Fanconi anemia pathway" involved in DNA repair, and report on the factors governing its stability.

17 Mar 2021

Researchers explore difference in reactions to SARS-CoV-2 infection between children and adults

The COVID-19 pandemic has claimed over 2.67 million lives in less than a year and a half. However, it is uncommon in children, with less than 2% of the cases being in individuals below the age of 19. Most of these are of mild severity, with the clinical features of severe COVID-19 being rare in this age group.

17 Mar 2021

INTEGRA’s electronic pipettes enable reproducible analysis in microbial evolution research

INTEGRA’s VOYAGER adjustable tip spacing pipette and VIAFLO lightweight electronic pipette are the perfect lab companions for agricultural research into microbial evolution.

From INTEGRA Biosciences 17 Mar 2021

Gene News and Research

Latest Gene News and Research

New drug regimen is safe and effective in children with cystic fibrosis

Scientists use clinical data to study the molecular groups of atypical teratoid rhabdoid tumor

Alliance for Cancer Gene Therapy provides new opportunity to develop cancer cell and gene therapies

Study reveals biomarkers for the prognosis of gastric adenocarcinoma

Weight loss induced by diet and bariatric surgery has different impact on mitochondria in fat tissue

Study explores how CAR T immunotherapy could be used to treat solid tumors

Molecule produced by the immune system can reduce potency of antibiotics

Novel cancer-fighting gene therapy enters phase I clinical trial

New study maps SARS-CoV-2 and host protein interactions in detail

New Alzheimer's model may help test novel treatments

Study confirms that higher level of maternal folate increases the child’s birthweight

GMP-Ready Helper Plasmids for AAV Production

Gene expression of viral entry factors may explain the differences of COVID-19 severity

Long noncoding RNA plays a vital role in mobilizing immune response after organ transplantation

A complete genetic and clinical analysis of individuals with SCN2A-related disorders

Beneficial effects of gene therapy can be seen in SCID-X1 patients decades after treatment

Researchers explore potential role of TARM1 protein in pathogenesis of rheumatoid arthritis

Insights into elusive protein complex can help find novel treatments for chromosomal disorders

Researchers explore difference in reactions to SARS-CoV-2 infection between children and adults

INTEGRA’s electronic pipettes enable reproducible analysis in microbial evolution research

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)