Gene News and Research

Latest Gene News and Research

Study reveals the genetic cause of congenital malformation

Study by the University of Bonn reveals that genetic information controls development of the urinary tract, rectum and genitals Spontaneous mutations of a single gene are likely to cause serious developmental disorders of the excretory organs and genitalia.

7 Aug 2020

Large-scale analysis of Alport syndrome reveals the effectiveness of existing treatments

A large-scale analysis of the clinical characteristics of Alport syndrome in Japanese patients has revealed that the effectiveness of existing treatment with ACE inhibitors and/or angiotensin receptor blockers (RAS inhibitors) varies depending on the type of mutation in the syndrome's causal gene (COL4A5).

7 Aug 2020

Study: Early training of cell development and network improves response

When it comes to training neural circuits for tissue engineering or biomedical applications, a new study suggests a key parameter: Train them young.

7 Aug 2020

Researchers use patient-specific tumor organoid to optimize chemotherapy for appendix, colon tumors

A patient-specific tumor organoid model is being used to identify the most effective chemotherapy protocol to treat appendix and colon tumors, a personalized medicine approach that is showing promise.

7 Aug 2020

Immune system derails during severe course of COVID-19

Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction - rather, the immune response is caught in a continuous loop of activation and inhibition.

6 Aug 2020

Study uncovers sex-specific differences in neural mechanisms for glucose regulation

Researchers at Tufts University School of Medicine and Tufts Graduate School of Biomedical Sciences have discovered neural mechanisms in mice specific to females that can shift estrogen from playing a protective role in glucose metabolism to one that is disruptive.

6 Aug 2020

Researchers develop a deep learning-based algorithm for predicting sites of DNA methylation

A team of researchers from New Jersey Institute of Technology and Children's Hospital of Philadelphia have developed an algorithm through machine learning that helps predict sites of DNA methylation - a process that can change the activity of DNA without changing its overall structure - and could identify disease-causing mechanisms that would otherwise be missed by conventional screening methods.

6 Aug 2020

Powerful treatment for IPF stops dangerous scar formation in mouse lungs

A pre-clinical study led by scientists at Cincinnati Children's demonstrates that in mice the drug barasertib reverses the activation of fibroblasts that cause dangerous scar tissue to build up in the lungs of people with idiopathic pulmonary fibrosis (IPF).

6 Aug 2020

Study finds evidence of gut dysbiosis in people with Huntington's disease

A world first clinical study of the gut microbiome in people with Huntington's disease (HD) has found that it is not just a disease of the brain, but also of the body.

6 Aug 2020

WVU RNI expands pioneering treatment for Alzheimer’s to open the blood-brain barrier

A hospital nurse for 33 years, Nanette Miller would call her husband Frank at the end of each shift to let him know she was coming home. On Dec. 7, 2018, the phone call came with a somber declaration: "I can't do this anymore."

6 Aug 2020

Tasmanian devil research provides new insights for treating human cancers in future

A rare, transmissible tumor has brought the iconic Tasmanian devil to the brink of extinction, but new research by scientists at Washington State University and the Fred Hutchinson Cancer Research Center in Seattle indicates hope for the animals' survival and possibly new treatment for human cancers.

6 Aug 2020

Specific gene impairment may also protect people with Down syndrome

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago discovered that a set of genes with decreased expression in individuals with Down syndrome may lead to clinical abnormalities in this population, such as poor muscle development and heart valve problems.

6 Aug 2020

Gene could predict treatment response in certain breast cancer patients

Scientists have identified a gene which if present in certain breast cancer patients indicates how they will respond to specific therapies.

6 Aug 2020

Unique molecular mechanics can pave way for potential treatments for infections

Unique molecular mechanics allowing parasites to thrive in the guts of one billion people open the door to new treatments that are safe for the host.

6 Aug 2020

Researchers shed new light on epigenetic changes associated with ADNP syndrome

A study led by the Seaver Autism Center for Research and Treatment at Mount Sinai found that two different blood epigenetic signatures associated with ADNP syndrome (also known as Helsmoortel-Van Der Aa syndrome) have only a modest correlation with clinical manifestations of the syndrome. The study results were published online August 5 in the American Journal of Human Genetics.

6 Aug 2020

Scientists create new mouse model of permanent neonatal diabetes

Diabetes seldom occurs in newborns--a condition known as neonatal diabetes. But when it does, it's mostly due to a mutation in a single gene such as the KCNJ11 or insulin (INS).

6 Aug 2020

Carefully engineered spike protein can help develop COVID-19 vaccine

The experimental vaccine against SARS-CoV-2 that was the first to enter human trials in the United States has been shown to elicit neutralizing antibodies and a helpful T-cell response with the aid of a carefully engineered spike protein that mimics the infection-spreading part of the virus.

6 Aug 2020

Researchers investigate why irregular heartbeats occur after stem cell transplantation

Stem cells are heavily studied around the world with the hope to revive damaged body parts unable to regenerate itself. Injured heart muscles are one of these areas which remain impaired in adults who have experienced heart attacks.

5 Aug 2020

3D organoid model helps better understand how tumor grows in natural microenvironment

Scientists at the Wake Forest Institute for Regenerative Medicine (WFIRM) have biofabricated human colorectal cancer miniature organs, called organoids, to better understand how a tumor grows in its natural microenvironment and its response to therapies.

5 Aug 2020

A SARS-CoV-2 assay using plant proteins

Researchers in South Africa have developed a serological assay that readily detects antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using recombinant viral proteins produced in plants.

5 Aug 2020

Gene News and Research

Latest Gene News and Research

Study reveals the genetic cause of congenital malformation

Large-scale analysis of Alport syndrome reveals the effectiveness of existing treatments

Study: Early training of cell development and network improves response

Researchers use patient-specific tumor organoid to optimize chemotherapy for appendix, colon tumors

Immune system derails during severe course of COVID-19

Study uncovers sex-specific differences in neural mechanisms for glucose regulation

Researchers develop a deep learning-based algorithm for predicting sites of DNA methylation

Powerful treatment for IPF stops dangerous scar formation in mouse lungs

Study finds evidence of gut dysbiosis in people with Huntington's disease

WVU RNI expands pioneering treatment for Alzheimer’s to open the blood-brain barrier

Tasmanian devil research provides new insights for treating human cancers in future

Specific gene impairment may also protect people with Down syndrome

Gene could predict treatment response in certain breast cancer patients

Unique molecular mechanics can pave way for potential treatments for infections

Researchers shed new light on epigenetic changes associated with ADNP syndrome

Scientists create new mouse model of permanent neonatal diabetes

Carefully engineered spike protein can help develop COVID-19 vaccine

Researchers investigate why irregular heartbeats occur after stem cell transplantation

3D organoid model helps better understand how tumor grows in natural microenvironment

A SARS-CoV-2 assay using plant proteins

eBook: Using iPSCs models for human disease research and drug discovery eBook

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting