Gene News and Research

Latest Gene News and Research

UAB researchers detail underlying mechanism leading to age-associated osteoporosis

A major health problem in older people is age-associated osteoporosis -- the thinning of bone and the loss of bone density that increases the risk of fractures. Often this is accompanied by an increase in fat cells in the bone marrow.

22 Sep 2017

Study identifies two genes involved in invasive group A Streptococcus infections

Group A Streptococcus bacteria cause a variety of illnesses that range from mild nuisances like strep throat to life-threatening conditions including pneumonia, toxic shock syndrome and the flesh-eating disease formally known as necrotizing fasciitis.

22 Sep 2017

Genome-wide study reveals how transposons get prepared for jumping

The genome of a typical organism consists of many genes that are stringed like beads. This alignment has been surprisingly stable even over very long evolutionary periods. In addition to these genes, there are also many mobile elements, referred to as parasitic, that are spread across the whole genome and aggregated into different families according to their relatedness.

22 Sep 2017

Multi-gene test found to be better at identifying older adults at risk for Alzheimer's

A new test that combines the effects of more than two dozen genetic variants, most associated by themselves with only a small risk of Alzheimer's disease, does a better job of predicting which cognitively normal older adults will go on to develop Alzheimer's dementia than testing only for the well-known genetic variant APOE E4, a scientific team led by researchers at UC San Francisco and UC San Diego has found.

22 Sep 2017

Novel approach facilitates long-term persistence of AAV vector genomes in proliferating cells

Researchers added a scaffold/matrix attachment region (S/MAR) to a conventional adeno-associated virus (AAV) vector used for gene transfer, and the modified vectors were able to establish colonies and maintain long-term transgene expression in HeLa cells, as reported in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

22 Sep 2017

Targeting mutant p53 specific binding protein could lead to new therapeutic strategies for cancer patients

Research by Rutgers Cancer Institute of New Jersey investigators shows the targeting of a binding protein of mutant p53 known as Rac1 could lead to new therapeutic strategies for patients whose cancer carries mutations in the p53 gene.

22 Sep 2017

Researchers use gene therapy to restore hearing and balance in mouse model of Usher syndrome

Hearing loss, sometimes associated with other disorders such as balance defects, is the most common sensory deficit, affecting more than 280 million people worldwide, according to WHO. In France, one child in 700 is born with severe or profound hearing loss, and one in every 1,000 will lose their sense of hearing before adulthood.

22 Sep 2017

New syndrome caused by biallelic mutations predisposes the body to tumors

A new syndrome caused by biallelic mutations - those produced in both gene copies inherited from the mother and father - in the FANCM gene predisposes the body to the appearance of tumours and causes rejection to chemotherapy treatments.

22 Sep 2017

Researchers discover mechanism of drug resistance for ovarian and breast cancer cells

Researchers from the People's Friendship University of Russia have studied the mechanism of drug resistance for ovarian and breast cancer cells.

22 Sep 2017

Hard water may contribute to development of eczema by damaging skin barrier

Researchers from the University of Sheffield and King’s College London have discovered that exposing the skin to hard water damages the skin barrier – which is our defense against outside threats such as bacteria or sun burn – and increases the sensitivity of the skin to potential irritants found in everyday wash products such as soap or washing powder.

22 Sep 2017

Study may contribute to genetic understanding of high-altitude adaptation

Many research groups have recently explored human adaptation and successfully identified candidate genes to high altitude living among three major far-flung global populations: Tibetans, Ethiopians and Peruvians.

22 Sep 2017

Alternative splicing may also trigger cancer, study shows

Cancer, which is one of the leading causes of death worldwide, arises from the disruption of essential mechanisms of the normal cell life cycle, such as replication control, DNA repair and cell death.

22 Sep 2017

'Labyrinth' chip may be new way to monitor cancer patients in clinical trials

Inspired by the Labyrinth of Greek mythology, a new chip etched with fluid channels sends blood samples through a hydrodynamic maze to separate out rare circulating cancer cells into a relatively clean stream for analysis. It is already in use in a breast cancer clinical trial.

21 Sep 2017

Gene News and Research

Latest Gene News and Research

UAB researchers detail underlying mechanism leading to age-associated osteoporosis

Study identifies two genes involved in invasive group A Streptococcus infections

Genome-wide study reveals how transposons get prepared for jumping

Multi-gene test found to be better at identifying older adults at risk for Alzheimer's

Novel approach facilitates long-term persistence of AAV vector genomes in proliferating cells

Targeting mutant p53 specific binding protein could lead to new therapeutic strategies for cancer patients

Researchers use gene therapy to restore hearing and balance in mouse model of Usher syndrome

New syndrome caused by biallelic mutations predisposes the body to tumors

Researchers discover mechanism of drug resistance for ovarian and breast cancer cells

Hard water may contribute to development of eczema by damaging skin barrier

Study may contribute to genetic understanding of high-altitude adaptation

Alternative splicing may also trigger cancer, study shows

'Labyrinth' chip may be new way to monitor cancer patients in clinical trials

Researchers identify molecular pathway that causes immune cells to promote cancer

Novel gene therapy can inhibit, reverse multiple sclerosis in mouse models

New discovery about high-risk Alzheimer’s gene suggests potential therapeutic target

Scientists use genome editing to understand role of a gene key to human embryonic development

Researchers identify new genetic test to help predict cancer recurrence

Study opens new door to potential treatments for highly lethal brain tumors

Communication breakdowns between care facilities can pave way for drug-resistant infection

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging