Genetics News and Research

Latest Genetics News and Research

$Amgen starts Phase 3 study assessing the benefit of Kyprolis in patients with relapsed/refractory multiple myeloma$

Amgen starts Phase 3 study assessing the benefit of Kyprolis in patients with relapsed/refractory multiple myeloma

Amgen today announced the initiation of the ARROW trial, a global Phase 3 study evaluating the benefit of Kyprolis® (carfilzomib) for Injection administered once-weekly with dexamethasone versus the current U.S. Food and Drug Administration (FDA) approved twice-weekly administration schedule in patients with relapsed and refractory multiple myeloma who have received prior treatment with bortezomib and an immunomodulatory agent (IMiD).

1 Jun 2015

PGDx introduces ImmunoSelect-R service to support development of immuno-oncology cancer therapies

Personal Genome Diagnostics, Inc., a provider of advanced cancer genome analysis and testing services, today announced the launch of its ImmunoSelect-R service designed to identify mutant neoantigens and support development of immuno-oncology cancer therapies.

1 Jun 2015

Phase III HELIOS trial results show ibrutinib combination therapy improves outcomes in CLL/SLL patients

Today, Pharmacyclics LLC announced the results of the Phase III HELIOS trial (CLL3001), which found that patients with previously treated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who received ibrutinib (IMBRUVICA) in combination with bendamustine and rituximab (BR) experienced an 80% reduction in the risk of progression or death compared to patients receiving placebo in combination with BR.

1 Jun 2015

Amgen and Merck expand collaboration for Talimogene laherparepvec-KEYTRUDA combination study

Amgen and Merck, known as MSD outside the U.S. and Canada, today announced an expanded collaboration to evaluate the efficacy and safety of talimogene laherparepvec, Amgen's investigational oncolytic immunotherapy, in combination with KEYTRUDA® (pembrolizumab), Merck's anti-PD-1 therapy, in a Phase 1, open-label trial of patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN).

1 Jun 2015

New clinical studies on Myriad Genetics myChoice HRD companion diagnostic test presented at ASCO 2015

Myriad Genetics, Inc. today announced new clinical studies on its myChoice HRD companion diagnostic test at the 2015 American Society of Clinical Oncology annual meeting being held in Chicago, Ill.

1 Jun 2015

ClinGen: New clinical genome resource may help understand clinical implications of genetic variants

Tremendous advances have been made in decoding the human genome in recent years but critical questions remain regarding what these variants mean and how they can be applied in clinical practice.

1 Jun 2015

Pharmacyclics initiates ibrutinib-MEDI4736 combination multi-center study for R/R DLBCL or FL

Pharmacyclics, Inc. today announced the initiation of PCYC-1136-CA, a multi-center study that will investigate the use of ibrutinib (IMBRUVICA®) in combination with MEDI4736, an investigational anti-PD-L1 immune checkpoint inhibitor being developed by AstraZeneca.

1 Jun 2015

Precision medicine helps improve patient health and reduces risk of side effects, says Penn Medical School dean

The rapidly emerging field of precision medicine is a "disruptive innovation" that offers the possibility of remarkably fine-tuned remedies to improve patient health while minimizing the risk of harmful side effects, says J. Larry Jameson, MD, PhD, dean of the Perelman School of Medicine and executive vice president of the University of Pennsylvania for the Health System, in this week's issue of the New England Journal of Medicine.

1 Jun 2015

Cancer genetic counselor helps patients make sense of genetics and statistics

Cancer was the second leading cause of death in the United States in 2013 and the American Cancer Society expects almost 10,000 new cases in New Mexico this year.

1 Jun 2015

Researchers awarded $3.86 million NIH grant to tackle the issue of 'mosaicism' in schizophrenia

Why does schizophrenia happen, and how can we improve treatment for it? These basic questions persist despite years of research on one of the most puzzling, and debilitating, mental illnesses. Now, a University of Michigan Medical School team and their colleagues will take a new approach to addressing these questions by searching for genetic clues in postmortem brain tissues of people with and without schizophrenia.

30 May 2015

Study suggests race-specific equations to aid clinicians better calculate warfarin dosage

A new report demonstrates that clinical and genetic factors affecting dose requirements for warfarin vary by race. The study, published online today in Blood, the Journal of the American Society of Hematology, proposes race-specific equations to help clinicians better calculate warfarin dosage.

30 May 2015

Myriad Genetics to highlight new clinical studies on myRisk Hereditary Cancer test at ASCO 2015

Myriad Genetics, Inc. today announced it will highlight several new clinical studies on its myRisk Hereditary Cancer molecular diagnostic test at the 2015 American Society of Clinical Oncology annual meeting being held in Chicago, Ill.

30 May 2015

Myriad Genetics announces new clinical studies on myChoice HRD companion diagnostic test at ASCO 2015

Myriad Genetics, Inc. today announced new clinical studies on its myChoice HRD companion diagnostic test at the 2015 American Society of Clinical Oncology annual meeting being held in Chicago, Ill.

30 May 2015

Study sheds light on genetic differences between colorectal cancer in older and younger patients

While the overall rate of colorectal cancer (CRC) is declining, CRC specifically among young patients is increasing. Previous studies have shown that CRC in patients younger than 50 years old tends to be more aggressive than CRC in older patients.

29 May 2015

Larger studies needed to validate multigene testing for prediction of breast cancer risk

While advances in technology have made multigene testing, or "panel testing," for genetic mutations that increase the risk of breast or other cancers an option, authors of a review published today in the New England Journal of Medicine say larger studies are needed in order to provide reliable risk estimates for counseling these patients.

29 May 2015

Amgen announces AMG 416 Phase 3 results for treatment of secondary hyperparathyroidism in CKD patients

Amgen today announced pooled data from two pivotal Phase 3, global, randomized, placebo-controlled trials evaluating AMG 416, a novel calcimimetic, for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) receiving hemodialysis.

29 May 2015

Amgen creates catalog of qualified tools and reagents to advance basic discoveries in biology

Amgen today announced the creation of a catalog of qualified tools and reagents available to academic institutions to help further research and advance basic discoveries in biology, as well as deepen relationships with academic institutions.

29 May 2015

Duke researchers reveal how bladder cells can eject UTI-causing bacteria

Duke Medicine researchers have found that bladder cells have a highly effective way to combat E. coli bacteria that cause urinary tract infections (UTIs).

29 May 2015

Robert Rountree honored with Linus Pauling Functional Medicine Award

Robert Rountree, MD, has been honored by receiving the Linus Pauling Functional Medicine Award at the Institute for Functional Medicine's 2015 Annual International Conference, being held May 28-30, 2015 in Austin, Texas. Dr. Rountree receives this award for his pioneering work in the development of Functional Medicine, and for his role as a highly inspirational and informational member of IFM's faculty.

29 May 2015

ACMG unveils new online educational portal focusing on genetics and genomic medicine

The American College of Medical Genetics and Genomics has unveiled its new ACMG Genetics Academy for Genetic and Genomic Education at www.acmg.net/education, an online educational portal where healthcare professionals interested in genetics and genomics in clinical and laboratory practice can enroll in courses and create their own personal learning management center.

28 May 2015

Genetics News and Research

Latest Genetics News and Research

Amgen starts Phase 3 study assessing the benefit of Kyprolis in patients with relapsed/refractory multiple myeloma

PGDx introduces ImmunoSelect-R service to support development of immuno-oncology cancer therapies

Phase III HELIOS trial results show ibrutinib combination therapy improves outcomes in CLL/SLL patients

Amgen and Merck expand collaboration for Talimogene laherparepvec-KEYTRUDA combination study

New clinical studies on Myriad Genetics myChoice HRD companion diagnostic test presented at ASCO 2015

ClinGen: New clinical genome resource may help understand clinical implications of genetic variants

Pharmacyclics initiates ibrutinib-MEDI4736 combination multi-center study for R/R DLBCL or FL

Precision medicine helps improve patient health and reduces risk of side effects, says Penn Medical School dean

Cancer genetic counselor helps patients make sense of genetics and statistics

Researchers awarded $3.86 million NIH grant to tackle the issue of 'mosaicism' in schizophrenia

Study suggests race-specific equations to aid clinicians better calculate warfarin dosage

Myriad Genetics to highlight new clinical studies on myRisk Hereditary Cancer test at ASCO 2015

Myriad Genetics announces new clinical studies on myChoice HRD companion diagnostic test at ASCO 2015

Study sheds light on genetic differences between colorectal cancer in older and younger patients

Larger studies needed to validate multigene testing for prediction of breast cancer risk

Amgen announces AMG 416 Phase 3 results for treatment of secondary hyperparathyroidism in CKD patients

Amgen creates catalog of qualified tools and reagents to advance basic discoveries in biology

Duke researchers reveal how bladder cells can eject UTI-causing bacteria

Robert Rountree honored with Linus Pauling Functional Medicine Award

ACMG unveils new online educational portal focusing on genetics and genomic medicine

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