Genetics News and Research

Latest Genetics News and Research

New insight into human ciliopathy

In the September 1st issue of G&D, Dr. Karen Oegema (UCSD) and colleagues identify the molecular basis of the lethal developmental disorder, hydrolethalus syndrome, and reveal that hydrolethalus syndrome actually belongs to the emerging class of human ciliopathy diseases.

4 Aug 2009

Genetic risk, not anesthesia exposure, impacts cognitive performance

A recent study of more than 2,000 identical twins found that medical problems early in life, rather than the neurotoxic effects of anesthesia, are likely linked to an individual's risk for developing learning disabilities.

4 Aug 2009

Flaw in bone's material leads to disease

The weak tendons and fragile bones characteristic of osteogenesis imperfecta, or brittle bone disease, stem from a genetic mutation that causes the incorrect substitution of a single amino acid in the chain of thousands of amino acids making up a collagen molecule, the basic building block of bone and tendon.

4 Aug 2009

New method selectively kills metastatic melanoma

An international team of researchers has identified a new method for selectively killing metastatic melanoma cells, which may lead to new areas for drug development in melanoma – a cancer that is highly resistant to current treatment strategies.

4 Aug 2009

Genetic link to ovarian cancer found

Scientists have located a region of DNA which - when altered - can increase the risk of ovarian cancer according to research published in Nature Genetics today.

3 Aug 2009

Discovery of mechanism that protects somatic cells against the behaviour of germ cells

An IRB Barcelona research team discovers the mechanism that favors the correct separation of germ cells -- future ovules and sperm -- from the rest of the cells during embryonic development

3 Aug 2009

Discovery of unique 'DNA signature' in human sperm - unlocks egg's fertility

Drs David Miller and David Iles from the University of Leeds, in collaboration with Dr Martin Brinkworth at the University of Bradford, have found that sperm writes a DNA signature that can only be recognised by an egg from the same species. This enables fertilisation and may even explain how a species develops its own unique genetic identity.

3 Aug 2009

Selective method kills metastatic melanoma cells

An international team of researchers has identified a new method for selectively killing metastatic melanoma cells, which may lead to new areas for drug development in melanoma - a cancer that is highly resistant to current treatment strategies.

3 Aug 2009

Opportunities and risks posed by synthetic biology

The new research field of synthetic biology will, in the medium term, open up a great deal of potential for combining novel genetic methods with engineering principles. This will facilitate the development, not only of new vaccines and medicines, but also of fuels and new materials.

3 Aug 2009

Gene therapy for retinitis pigmentosa

An international team of scientists and clinicians from the United States and Saudi Arabia are working to develop gene therapy for treating a rare, hereditary retinal disease.

31 Jul 2009

New journal devoted to gene therapy and human genetics

The Gene Therapy Review was first launched in 2008 as an online source of information on all aspects of gene therapy with sections comprising information on gene therapy research, news, disease targets, patient resources and companies offering services to the gene therapy community. It then further featured a clinical trials database detailing all gene therapy clinical procedures completed to date.

31 Jul 2009

Discovery of genetic link to age-related cataracts

Bing-Cheng Wang, Ph.D., Case Western Reserve University School of Medicine professor of pharmacology and senior staff scientist at MetroHealth Medical Center, and Sudha K. Iyengar, Ph.D. professor of genetic and molecular epidemiology at Case Western Reserve University School of Medicine, have discovered the first gene associated with the formation of age-related cataracts, a leading causes of blindness.

31 Jul 2009

Virus may play role in causing some cases of squamous cell carcinoma

A virus discovered last year in a rare form of skin cancer has also been found in people with the second most common form of skin cancer among Americans, according to researchers at the Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute.

31 Jul 2009

Epigenetic signature changes in low oxygen levels may contribute to prostate cancer development

UCD Conway researchers have characterised epigenetic signature changes in prostate cells under conditions of low oxygen levels that may lead to tumour development.

30 Jul 2009

Malaria vaccine in the pipeline

Australian scientists have developed the first genetically-engineered malaria vaccine and the vaccine will be trialled in humans early next year.

29 Jul 2009

Maternal exposure to nanoparticles related to neurological dysfunction in the mouse

Maternal exposure to nanoparticles of titanium dioxide (TiO2) affects the expression of genes related to the central nervous system in developing mice. Researchers writing in BioMed Central's open access journal Particle and Fibre Toxicology found that mice whose mothers were injected with the nanoparticles while pregnant showed alteration in gene expression related to neurological dysfunction.

28 Jul 2009

Scientists re-engineer human enzyme to become resistant to harmful agents such as chemotherapy

Scientists from the Université de Montréal and McGill University have re-engineered a human enzyme, a protein that accelerates chemical reactions within the human body, to become highly resistant to harmful agents such as chemotherapy, according to a new study published in The Journal of Biological Chemistry.

28 Jul 2009

Analysis suggests human development is set by ongoing interplay of parent and offspring genes

An analysis of rare genetic disorders in which children lack some genes from one parent suggests that maternal and paternal genes engage in a subtle tug-of-war well into childhood, and possibly as late as the onset of puberty.

28 Jul 2009

miR-21 molecule plays early and important role in nonsmoking lung cancer

The cause of lung cancer in never-smokers is poorly understood, but a study led by investigators at the Ohio State University Comprehensive Cancer Center and at the National Cancer Institute has identified a molecule believed to play an early and important role in its development.

28 Jul 2009

Gene expression patterns in cancer could aid early screening and prevention

Distinctive patterns of genes turned off - or left on - in healthy versus cancerous cells could enable early screening for many common cancers and maybe help avoid them, Medical College of Georgia scientists say.

28 Jul 2009