Genetics News and Research

Latest Genetics News and Research

Shared gene expression alterations in schizophrenia and bipolar disorder

Both schizophrenia and bipolar disorder can be disabling conditions, and both present clinically with significant mood and psychotic symptoms. These two illnesses also share genetic variants that might be involved in the predisposition to both disorders.

17 Jul 2008

Gene variant increases HIV risk in Africans

A genetic variation which evolved to protect people of African descent against malaria has now been shown to increase their susceptibility to HIV infection by up to 40 per cent, according to new research. Conversely, the same variation also appears to prolong survival of those infected with HIV by approximately two years.

17 Jul 2008

New therapies revealed for diabetes-induced microvascular disease

New findings from Bristol scientists could lead to future treatments to prevent lower limb amputations in diabetes - which currently affect 100 people a week in the UK (source Diabetes UK). The research from the University of Bristol is published online in Circulation Research and was funded by the British Heart Foundation (BHF) and the European Vascular Genomic Network of Excellence (EVGN).

17 Jul 2008

New British consortium to tackle healthcare associated infections

Just over 8% of all hospital inpatients in England develop a healthcare associated infection, with this figure rising to 23% in intensive care units. Preventing and controlling the transmission of infection is a key priority for those involved in healthcare.

16 Jul 2008

New understanding of fetal hemoglobin regulation in patients with sickle cell disease

Although sickle cell disease is a single-gene disorder, its symptoms are highly variable. In a study published online July 14 by the Proceedings of the National Academy of Sciences, scientists at Children's Hospital Boston and the Dana Farber Cancer Institute (DFCI), in collaboration with the Broad Institute of MIT and Harvard, report five gene variants that could potentially be helpful in predicting sickle cell disease severity, perhaps even leading to better treatment approaches in the future.

15 Jul 2008

"Smothered" genes combine with mutations to yield poor out come in cancer patients

Johns Hopkins Kimmel Cancer Center researchers have identified a set of genes in breast and colon cancers with a deadly combination of traditional mutations and "smothered" gene activity that may result in poor outcomes for patients.

15 Jul 2008

Improving understanding of cell behaviour in breast cancer

The invasion and spread of cancer cells to other parts of the body, known as metastasis, is a principal cause of death in patients diagnosed with breast cancer. Although patients with early stage, small, breast tumours have an excellent short term prognosis, more than 15 to 20 per cent of them will eventually develop distant metastases, and die from the disease. Vascular invasion - through lymphatic and blood vessels - is the major route for cancer spreading to regional lymph nodes and to the rest of the body.

15 Jul 2008

New technology revolutionizing drug discovery

The National Science Foundation has awarded Weill Cornell Medical College researcher Dr. Scott Blanchard its prestigious Career Award, recognizing his groundbreaking work in cell biology -- work that is poised to revolutionize research for the next generation of young scientists.

15 Jul 2008

Virus injection could offer long term relief for Parkinson's

Gene therapy could offer a new, long-lasting way to treat Parkinson's disease, research results announced Tuesday 15 July at FENS 2008 suggest. Dr Deniz Kirik of the University of Lund in Sweden has been using viruses to insert a new combination of genes into animals' brains, where they help produce the dopamine that is lacking in Parkinson's disease. The results suggest the treatment is very effective in animal models for several months, possibly years.

15 Jul 2008

Guidelines to prevent genetic discrimination

A multi-disciplinary group from Stanford University (California, US) has proposed ten principles to guide the use of racial and ethnic categories in genetic research, as reported today in BioMed Central's open access journal Genome Biology.

15 Jul 2008

An inflamed response

Paul Martin, Professor of Cell Biology in the University of Bristol Departments of Physiology and Pharmacology, and Biochemistry, talked to Cherry Lewis about the discovery made in his lab that speeds up wound healing and reduces the size of the wound scar. She was interested not only in the discovery itself, but also in the processes and years of research that led up to it.

15 Jul 2008

Variations in the serotonin transporter gene may determine who responds best to antidepressant

A new Mayo Clinic study shows that variations in the serotonin transporter gene could explain why some people with depression respond better than others to treatment with citalopram (Celexa), an antidepressant medication.

14 Jul 2008

Apert's syndrome - new discovery

In a cruel irony, testis cells carrying the mutation that causes Apert's syndrome are fitter than normal cells, even though children born from sperm derived from those cells are weakened by fused fingers, toes and skulls, a new study has found.

14 Jul 2008

Susceptibility to pain is affected by premature birth and also genetics

Scientists in US and UK laboratories have made key discoveries into the elusive nature of pain in children and adults. The results, presented at the Forum of European Neurosciences Monday will help guide the future management and treatment of pain.

14 Jul 2008

Discover of key patterns in gene packaging

Although every cell of our bodies contains the same genetic instructions, specific genes typically act only in specific cells at particular times. Other genes are "silenced" in a variety of ways. One mode of gene silencing depends upon the way DNA, the genetic material, is packed in the nucleus of cells.

13 Jul 2008

Researches identify herpesvirus proteins that target key cellular processes

A study published July 11th in the open-access journal PLoS Pathogens suggests that herpesviruses use multiple strategies to manipulate important components of the host cell nuclear environment during infection.

13 Jul 2008

Common genetic variations increase risk of life-long nicotine addiction for young smokers

Common genetic variations affecting nicotine receptors in the nervous system can significantly increase the chance that European Americans who begin smoking by age 17 will struggle with life-long nicotine addiction. Published July 11 in the open-access journal PLoS Genetics, this research - led by scientists at the University of Utah together with colleagues from the University of Wisconsin - highlights the importance of preventing early exposure to tobacco through public health policies.

13 Jul 2008

Potential treatment for TB solves puzzle

Scientists have uncovered a new target for the potential treatment of TB, finally resolving a long-running debate about how the bacterial cell wall is built.

13 Jul 2008

Researchers find six genes that, when mutated, contribute to autism

The hunt for gene mutations that contribute to autism has proceeded slowly, largely because autism encompasses a spectrum of diseases. Just as its symptoms vary widely among individuals, so do the genetic mutations that cause them.

10 Jul 2008

Proof-of-concept that purified muscle stem cells can be used in therapy

By injecting purified stem cells isolated from adult skeletal muscle, researchers have shown they can restore healthy muscle and improve muscle function in mice with a form of muscular dystrophy. Those muscle-building stem cells were derived from a larger pool of so-called satellite cells that normally associate with mature muscle fibers and play a role in muscle growth and repair.

10 Jul 2008