Metabolism

Metabolism is the means by which the body derives energy and synthesizes the other molecules it needs from the fats, carbohydrates and proteins we eat as food, by enzymatic reactions helped by minerals and vitamins.

What is Anabolism?

Anabolism is the process by which the body utilizes the energy released by catabolism to synthesize complex molecules. These complex molecules are then utilized to form cellular structures that are formed from small and simple precursors that act as building blocks.

What is Metabolism?

Science of Metabolism

Metabolism Key Biochemicals

Metabolism Catabolism

Metabolism Energy Transformations

Xenobiotics and Redox Metabolism

Gibbs Free Energy and Metabolism

Metabolism Evolution

Metabolism Investigation and Manipulation

Metabolism History

Metabolism Control

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Metabolism Thermodynamics

What are Cytochrome P450 (CYP) Enzymes?

Science of Metabolism

Latest Metabolism News and Research

Inflammatory factors that aggravate COVID-19 may come from adipose tissue

There is growing evidence that adipose tissue plays a key role in the aggravation of COVID-19. One of the theories under investigation is that fat cells (adipocytes) act as a reservoir for SARS-CoV-2 and increase viral load in obese or overweight individuals.

20 Nov 2020

Age is no barrier to losing weight, study shows

Obese patients over the age of 60 can lose an equivalent amount of weight as younger people using only lifestyle changes, according to a new study from the University of Warwick and University Hospitals Coventry and Warwickshire NHS Trust that demonstrates that age is no barrier to losing weight.

20 Nov 2020

Researchers identify CLCN6 as disease gene for severe lysosomal neurodegenerative disorder

A mutation in the CLCN6 gene is associated with a novel, particularly severe neurodegenerative disorder. Scientists from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie and the Max Delbrück Center für Molekulare Medizin, together with an international team of researchers, have now analyzed the effect of a point mutation that was found in three unrelated affected children.

19 Nov 2020

Study identifies enzyme vital to the metastatic growth of prostate cancer cells

While prostate cancer originates within the prostate, metastasis, or the spread of a tumor from the site of origin to other organs, remains a leading cause of death among people with the disease.

19 Nov 2020

Altered gut microbiota increases production of molecules that may contribute to type 2 diabetes

It is the bacterial changes in the gut that increase the levels of imidazole propionate, the molecule that makes the body's cells resistant to insulin in type 2 diabetes. This result emerges from a European study, MetaCardis.

18 Nov 2020

Researchers use proteogenomics to better understand the biological complexity of breast cancer

Researchers at Baylor College of Medicine, the Broad Institute of MIT and Harvard and other institutions have applied powerful proteogenomics approaches to better understand the biological complexity of breast cancer.

18 Nov 2020

UC researcher receives $443,000 NIH grant to study antiviral drugs

University of Cincinnati pharmaceutical sciences researcher Bingfang Yan, DVM, has received a $443,000 grant from the National Institutes of Health to study how common medicines against viral infections are genetically impacted for therapeutic effectiveness and safety through metabolic conversions in the body.

18 Nov 2020

CRYM protein counteracts the growth of prostate tumors

Prostate cancer is caused by elevated hormone levels, and tumors are generally treated using hormone therapy. However, after some time, tumor growth is no longer dependent on hormones, which results in resistance to treatment. As a result, new types of treatments are urgently needed.

18 Nov 2020

Severe COVID-19 complications linked to gut barrier breakdown

A new study claims that severe COVID-19 is caused by a positive feedback loop triggered by systemic inflammation and mediated by abnormal gut permeability. This finding could potentially help open up new avenues of treatment.

18 Nov 2020

Study reveals the metabolic signaling mechanisms that regulate function of eTreg cells

Effector regulatory T cells (eTreg cells) are a specialized subset of white blood cells that keep the immune system in check.

17 Nov 2020

Manipulating mitochondria to improve the efficiency of neuronal reprogramming

The replacement of lost neurons is a holy grail for neuroscience. A new promising approach is the conversion of glial cells into new neurons. Improving the efficiency of this conversion or reprogramming after brain injury is an important step towards developing reliable regenerative medicine therapies.

17 Nov 2020

Study identifies new factor that offers potential strategy for treating obesity

Obesity is a serious global health problem and a risk factor for diseases such as type II diabetes, heart disease and fatty liver disease.

17 Nov 2020

Hydrogen therapy may help severely ill COVID-19 patients

Researchers from the Department of Critical Care Medicine, Sichuan Provincial People's Hospital, Chengdu in China, have explored the possibility of using hydrogen therapy on severely ill COVID-19 patients. The team published their study's findings, titled "Hydrogen: A Potential New Adjuvant Therapy for COVID-19 Patients," in the latest issue of the journal Frontiers in Pharmacology.

17 Nov 2020

Study: Novel drug may treat reproductive health problems in women

A drug that acts via the natural 'kisspeptin' hormone system in the body has the potential to treat reproductive health problems in women, according to a new study.

17 Nov 2020

Affinity-Bead Assisted Mass Spectrometry for Proteomics

In this interview, Ghaith Hamza from AstraZeneca talks to News-Medical Life Sciences about the basic principles of Affinity-Bead Assisted Mass Spectrometry (Affi-BAMS) and how Affi-BAMS can help target specific proteins for proteomic applications.

From Bruker Daltonics 16 Nov 2020

Machine-learning based analysis of mitochondria interaction networks to advance PD diagnosis

In a new study led by the Immune Systems Biology research group of the LIH Department of Infection and Immunity, researchers adopted a holistic machine-learning approach to elucidate how the interactions between neuronal mitochondria can serve as a powerful tool to distinguish nerve cells from Parkinson’s patients from those belonging to healthy subjects, thereby providing new insights in the pathogenesis, diagnosis and treatment of this neurodegenerative disorder.

12 Nov 2020

Discovering a new role for a protein that could cause breast cancer to spread to the lungs

In this interview, News-Medical speaks to Dr. Cristina Branco from Breast Cancer Now about the spread of breast cancer cells to the lungs.

12 Nov 2020

Study explores connection between internal biological clocks and beta cell regeneration

Certain parts of our body, such as the skin or liver, can repair themselves after a damage. Known as cell regeneration, this phenomenon describes how cells that are still functional start to proliferate to compensate for the loss.

12 Nov 2020

Experts publish Consensus Statement on management of osteoporosis in patients with CKD G4–G5D

Patients with advanced chronic kidney disease (CKD) suffer from impaired bone quality and quantity, with a non-vertebral fracture risk which is 4-to 6-fold higher than the fracture risk of matched controls.

11 Nov 2020

Effectiveness of vitamin C against COVID-19 depends on its natural transporter levels

High doses of vitamin C under study for treating COVID-19 may benefit some populations, but investigators exploring its potential in aging say key factors in effectiveness include levels of the natural transporter needed to get the vitamin inside cells.

11 Nov 2020