Metabolism News and Research

Latest Metabolism News and Research

Viagra ingredient improves symptoms in patients with Leigh syndrome

Sildenafil – an active ingredient also marketed under the name of Viagra – improves symptoms in patients with Leigh syndrome.

11 Mar 2026

Low testosterone and high fructose intake can worsen fatty liver disease

Low testosterone in itself can cause a variety of health problems, but the addition of a poor diet can exacerbate certain conditions. Metabolic dysfunction-associated steatotic liver disease (MASLD) is one example that approximately 40% of adult men worldwide currently suffer from and has become a global problem.

11 Mar 2026

Specific gut microbe may boost muscle strength and performance

A species of gut bacteria called Roseburia inulinivorans is specifically associated with human muscle strength and improved muscular performance in mice, finds research published online in the journal Gut.

10 Mar 2026

Postbiotics may help treat PCOS by restoring microbiome balance

Emerging studies suggest postbiotics could aid PCOS management by restoring gut microbiome balance and enhancing insulin sensitivity and hormonal regulation.

10 Mar 2026

EVA1A regulates fatty acid transporter CD36 in fatty liver disease

Metabolic Dysfunction-Associated Steatotic Liver Disease（MASLD） is characterized by excessive accumulation of lipids in hepatocytes and is closely associated with the rapid rise in insulin resistance, obesity, and diabetes prevalence, making it one of the most common chronic liver diseases worldwide.

9 Mar 2026

Specific gut bacteria may signal long-term risk of heart and metabolic disease

Researchers analyzed gut microbiome profiles from 4,792 adults in the HELIUS cohort and tracked cardiometabolic outcomes over time to determine whether specific microbes predict disease risk. Certain microbes were linked to higher or lower cardiovascular risk, while plant-derived microbial metabolites suggested potential diet–microbiome interactions influencing heart health.

9 Mar 2026

Scientists simulate complete life cycle of a minimal bacterial cell

By simulating the life cycle of a minimal bacterial cell - from DNA replication to protein translation to metabolism and cell division - scientists have opened a new frontier of computer vision into the essential processes of life.

9 Mar 2026

Microbial ecosystems influence success of cancer checkpoint immunotherapy

Immune checkpoint inhibitors targeting PD-1 and PD-L1 have revolutionized cancer therapy, delivering long-term survival benefits in several malignancies.

9 Mar 2026

FOXJ3 gene identified as the critical link between abnormal brain development and epilepsy

Researchers have discovered that mutations in the FOXJ3 gene act as a "master switch" failure, disrupting how the brain builds its layers and leading to FCD, a primary cause of drug-resistant epilepsy.

9 Mar 2026

Ketone body can strengthen the fitness and antitumor activity of CAR T cells

A naturally occurring byproduct of liver metabolism–the ketone body, β-hydroxybutyrate (BHB)–can strengthen the fitness and antitumor activity of CAR T cells.

6 Mar 2026

Disrupted iron levels after SARS-CoV-2 infection may trigger long COVID

Problems with iron levels in the blood and the body's ability to regulate this important nutrient as a result of SARS-CoV-2 infection could be a key trigger for long COVID, new research has discovered.

6 Mar 2026

Research reveals nuclear metabolic fingerprint in human cells

More than two hundred metabolic enzymes, many of which are normally tasked with producing energy in the mitochondria, are also found sitting directly on top of human DNA, according to a study published today in Nature Communications.

6 Mar 2026

Weekend lie-ins may boost insulin sensitivity, but too much may backfire

This study explores the relationship between sleep patterns and insulin sensitivity, emphasizing the impact of weekday sleep and weekend catch-up on metabolism.

6 Mar 2026

Dual targeting strategy may improve treatment for resistant lung cancers

Findings from a study led by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) support the potential of new therapies that could improve clinical outcomes for patients with squamous and adenocarcinoma non-small cell lung cancers (NSCLC) that don't respond to immunotherapy.

5 Mar 2026

New strategy boosts immunotherapy against aggressive ovarian cancer

Cells in our immune system are best known for providing security against external invaders such as bacteria and viruses. These immune cells also guard against internal threats, including cancerous tumors.

5 Mar 2026

Drug combination shows greater weight loss while preserving muscle mass

A recent research study found that a combination of the GLP-1 receptor agonist semaglutide and bimagrumab, an antibody that blocks activin signaling pathways, results in greater weight loss while also preserving lean mass, such as skeletal muscle and connective tissue.

5 Mar 2026

Researchers propose that Parkinson’s disease may start in the gut, not the brain

A perspective in The Journal of Clinical Investigation argues that environmental exposures may interact with the gut microbiome and intestinal barrier to trigger biological processes linked to Parkinson’s disease. The authors propose that cumulative environmental stressors can erode host resilience, promoting α-synuclein pathology, immune activation, and neurodegeneration.

5 Mar 2026