Metabolism News and Research

Latest Metabolism News and Research

Gut bacterial metabolite linked to inflammation in liver disease

Researchers have identified a link between specific activities in gut bacteria and the liver disease PSC.

4 Sep 2026

MXene-based hydrogel offers dual-action treatment for periodontitis

Periodontitis is a highly prevalent chronic inflammatory disease worldwide. It leads to periodontal tissue destruction, alveolar bone resorption, and ultimately tooth loosening and loss, severely impacting patients' oral function and quality of life.

4 Sep 2026

Gut bacterial molecule discovered to drive serious bile duct disease

Researchers at the University of Oslo and Oslo University Hospital have, together with international collaborators, discovered that a small molecule made exclusively by gut bacteria can actively drive disease in the bile ducts and worsen primary sclerosing cholangitis (PSC), a serious liver and bile duct disease.

4 Sep 2026

Tumor environments sculpt diverse natural killer cells for cancer therapies

For decades, natural killer (NK) cells have been classified into two main groups based on surface markers: one specialized for cytokine production and the other for direct killing.

4 Sep 2026

Crucial brain stem cells rely on metabolic pathways to make decisions

As the human brain takes shape before birth, a remarkable type of stem cell helps give it many of the features that make it distinctly human.

4 Sep 2026

Submicron IR map of the human cell: Label free cellular imaging with O-PTIR, FTIR and Raman

What if you could map the chemistry inside a human cell - without fluorescent labels or stains?

From Photothermal Spectroscopy Corp 4 Sep 2026

What your gut microbes may have to do with how your brain ages

This review examines how diet-driven changes in the gut microbiota and microbial metabolites may influence cognitive aging through immune, metabolic, neural, endocrine, and barrier-related pathways. It highlights SCFAs, tryptophan-derived metabolites, and bile acids as key signaling mediators while emphasizing that much of the mechanistic evidence remains preclinical and human evidence is largely associative.

3 Sep 2026

The obesity-microbiome story is more complicated than ‘good’ and ‘bad’ bacteria

This review finds that obesity is linked to reciprocal interactions between diet, the gut microbiome, microbial metabolites, and host metabolic pathways that influence appetite, insulin sensitivity, inflammation, and energy balance across the lifespan. It highlights diet as a particularly tractable way to influence this system, while emphasizing that microbiome changes associated with GLP-1 therapies remain difficult to separate from weight loss and that functional multi-omics approaches may help enable more personalized interventions.

3 Sep 2026

Semaglutide extended lifespan in older female mice, but that was not the only finding

Late-life semaglutide treatment slowed age-related physiological decline, attenuated multiple molecular hallmarks of aging, and extended median lifespan from 742 to 834 days in aged female mice. The drug reproduced many effects of calorie restriction while providing additional benefits in exploratory behavior, spatial memory, and glucose control, suggesting that some effects extend beyond reduced calorie intake alone.

3 Sep 2026

Coffee, tea and dementia risk: Why the amount you drink could matter

A targeted perspective synthesizes epidemiological and mechanistic evidence examining how caffeine consumption during midlife may influence dementia risk later in life. The authors highlight potential roles for dose, age, CYP1A2 genotype, adenosine signaling and cultural drinking practices, while stressing that current observational evidence cannot establish causality.

3 Sep 2026

Cancer-fighting T cells need small amounts of ROS to attack tumors, study finds

New research reveals a promising new target for treating cancer by harnessing a type of molecule previously thought to do more harm than good.

3 Sep 2026

Eight-year study reveals how molecular aging scripts differ individually

Aging does not appear to follow the same molecular script for everyone, according to an eight-year study of 335 women.

3 Sep 2026

Yeast study shows how membrane lipids slow protein transport

A study in budding yeast suggests that changes in membrane lipids trigger a braking system that slows internal protein transport when the endoplasmic reticulum comes under stress, comparable to modern logistics networks where shipments are slowed when distribution hubs are under stress.

3 Sep 2026

New optical imaging reveals metabolic activity of individual immune cells

A routine blood sample contains a diverse collection of immune cells that can reveal important clues about health and disease.

2 Sep 2026

Shared biological pathways may explain chronic fatigue across diseases

A shared biological secret that helps explain chronic exhaustion in conditions including long Covid and PTSD has been discovered by researchers at the University of East Anglia and Oxford BioDynamics.

2 Sep 2026

Why addiction researchers are paying closer attention to GLP-1 drugs

A Journal of Clinical Investigation Viewpoint highlights growing evidence that GLP-1 receptor agonists, particularly semaglutide, may reduce alcohol consumption and some other substance-related outcomes by acting on brain systems involved in reward, motivation, stress, and emotion. However, the authors caution that efficacy for substance use disorders is not yet firmly established and call for further research into optimal dosing, treatment duration, patient selection, mechanisms, and effects across different addictions.

2 Sep 2026

Coffee’s link to Parkinson’s risk may depend on how your body handles caffeine

In 435,551 UK Biobank participants followed for a median of 15.7 years, overall coffee consumption was not associated with Parkinson’s disease risk, but the relationship differed significantly according to CYP1A2 genotype. Lower risk was observed with low-to-moderate coffee intake among fast-metabolizer AA carriers, while higher intake was associated with increased risk among AC and CC carriers, although the observational findings do not establish causality and sex-specific patterns require cautious interpretation.

2 Sep 2026

Researchers identify a previously unknown mechanism that can drive cancer cachexia

Researchers at Helmholtz Munich, the Heidelberg Faculty of Medicine at Heidelberg University, the German Center for Diabetes Research (DZD) and the Technical University of Munich (TUM), have identified a previously unknown mechanism that can drive cancer cachexia – a wasting process in the body that primarily affects muscle and fat tissue.

1 Sep 2026

Study links protein interaction to senescent cell survival

Senescent cells - cells that have stopped dividing but remain metabolically active - can accumulate with age and contribute to chronic inflammation and tissue dysfunction

1 Sep 2026

New nondestructive imaging technique tracks immune cell health

When a patient is facing certain cancers or an immune condition, clinicians turn to their white blood cells for clues about the progression of both diseases and their treatments.

1 Sep 2026