Metabolism News and Research

Latest Metabolism News and Research

Researchers develop mild mitochondrial uncouplers for obesity treatment

Researchers have developed experimental drugs that encourage the mitochondria in our cells to work a little harder and burn more calories. The findings could open the door to new treatments for obesity and improve metabolic health.

24 Dec 2025

CT-based quantification of tumor fibrosis guides chemotherapy in pancreatic cancer

On October 3, 2025, a multicenter team from Shenzhen University, Xiangya Hospital of Central South University, Zhujiang Hospital of Southern Medical University, Wuxi People's Hospital Affiliated to Nanjing Medical University, among others jointly reported a novel noninvasive method for quantifying tumor fibrosis based on preoperative enhanced CT.

23 Dec 2025

Reframing the role of MCL1 in cancer signaling and metabolism

A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD Faculty of Medicine provides fundamental insights into cancer biology.

22 Dec 2025

Remodeling the tumor microenvironment to unlock CAR-T cell potential

Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized hematologic cancer treatment, but its efficacy in solid tumors remains limited by poor infiltration into the complex tumor microenvironment (TME).

22 Dec 2025

Splicing regulator U2AF1 promotes angiogenesis in cardiac injury

A study published in Engineering shows that a protein called U2 small nuclear RNA auxiliary factor 1 (U2AF1), released by immune cells known as macrophages, helps grow new blood vessels in the heart after a myocardial infarction (MI) by altering how the gene Yap1 is spliced.

22 Dec 2025

Blood metabolite profiling outperforms BMI in predicting pregnancy complications

This study shows that a blood-based metabolomic signature linked to maternal BMI predicts gestational diabetes and preeclampsia more strongly than BMI alone, particularly in late pregnancy. A subset of 16 metabolites statistically mediates the BMI–gestational diabetes association, highlighting metabolic pathways that may improve prenatal risk stratification.

21 Dec 2025

Simple fruit granola intervention shows promising cardio-renal signals in CKD patients

A single-arm intervention study in Japanese adults with moderate chronic kidney disease found that replacing breakfast with fruit granola for two months lowered systolic blood pressure, reduced LDL-related lipid markers, and decreased a urinary marker of tubular injury. Renal function remained stable, bowel habits improved, and findings were exploratory due to the small, open-label design.

21 Dec 2025

New grant supports research into drug-induced brain toxicity

Important FDA-approved drugs to treat HIV and cancer can save lives, but they come with their own risks. Some drugs used clinically are known to cause neurological side effects in up to half of patients, ranging from confusion and memory problems to permanent nerve damage.

19 Dec 2025

Nanoplastics alter the gut barrier and metabolism depending on diet

A team of researchers from INRAE, CNRS, and the University of Lille studied how low dietary doses of nanoplastics affected mice.

19 Dec 2025

DNA twisting controls how cells respond to estrogen

Estrogens, the main female sex hormone, although they also perform some functions in men, are involved in a myriad of processes, which is why the body changes so much during menopause. This is because estrogens regulate hundreds of genes.

19 Dec 2025

Lifelong physical activity linked to lower metabolic syndrome risk

A new Finnish study shows that adults who remain physically active throughout adulthood have a markedly lower prevalence of metabolic syndrome at the age of 61 than those whose leisure-time physical activity remains low.

19 Dec 2025

Autophagy steers T cell fate during immune division

Researchers at the Max Delbrück Center have found that a cellular housekeeping mechanism called autophagy plays a major role in ensuring that T stem cells undergo normal cell division.

19 Dec 2025

Gestational diabetes alters the placenta at the molecular level, study reveals

Gestational diabetes can cause a multitude of complications in the offspring, but to date, the reasons are incompletely understood.

18 Dec 2025

Scientists unravel how citrin deficiency can trigger fat buildup in the liver even in lean individuals

Scientists at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the U.S. and a leading research center for diabetes and other life-threatening illnesses, have unraveled how citrin deficiency (CD), a rare genetic disorder that prevents the liver from converting food into energy efficiently, can trigger fat buildup in the liver - even in lean individuals.

18 Dec 2025

Folate deficiency drives genetic changes linked to lung cancer

Genetic alterations lie at the heart of cancer development, but scientists may have been overlooking a powerful driver of these changes—the everyday nutrients that feed our cells.

18 Dec 2025

Social living allows genetic effects to spread through the gut microbiome

Your "roommate's" genes could be influencing the bacteria living in your gut, and vice versa, according to a study of rats published today in Nature Communications.

18 Dec 2025

Distant astrocytes found to play a key role in spinal cord repair

Cedars-Sinai investigators have discovered a healing mechanism that could one day be harnessed to help treat patients with spinal cord injuries, stroke, and neurological conditions such as multiple sclerosis.

17 Dec 2025

Intermittent fasting edges daily calorie cuts for blood pressure and long-term cardiovascular risk estimates

In a real-world registry study of adults with overweight or obesity, 5:2 intermittent fasting and daily calorie restriction both improved blood pressure over 12 weeks. Intermittent fasting produced modestly greater reductions in systolic and pulse pressure and a larger drop in BMI-based 30-year cardiovascular risk scores, without superior lipid or glycaemic effects.

17 Dec 2025

Early embryos and the uterus engage in active communication during implantation

A new study shows that the embryo and the uterine lining conduct an active "conversation" from the very earliest stages of implantation. They engage in a back and forth of tiny packages called extracellular vesicles and lipid droplets, which carry metabolites and signals.

17 Dec 2025

How Traditional Chinese Medicine may reshape the gut microbiome to ease insulin resistance in PCOS

This review synthesizes evidence that gut microbiota dysbiosis contributes to insulin resistance and symptom severity in polycystic ovary syndrome through impaired barrier function, inflammation, and altered microbial metabolites. It evaluates how Traditional Chinese Medicine may modulate these pathways while highlighting major gaps in clinical validation, safety, and standardization.

16 Dec 2025

Metabolism News and Research

Latest Metabolism News and Research

Researchers develop mild mitochondrial uncouplers for obesity treatment

CT-based quantification of tumor fibrosis guides chemotherapy in pancreatic cancer

Reframing the role of MCL1 in cancer signaling and metabolism

Remodeling the tumor microenvironment to unlock CAR-T cell potential

Splicing regulator U2AF1 promotes angiogenesis in cardiac injury

Blood metabolite profiling outperforms BMI in predicting pregnancy complications

Simple fruit granola intervention shows promising cardio-renal signals in CKD patients

New grant supports research into drug-induced brain toxicity

Nanoplastics alter the gut barrier and metabolism depending on diet

DNA twisting controls how cells respond to estrogen

Lifelong physical activity linked to lower metabolic syndrome risk

Autophagy steers T cell fate during immune division

Gestational diabetes alters the placenta at the molecular level, study reveals

Scientists unravel how citrin deficiency can trigger fat buildup in the liver even in lean individuals

Folate deficiency drives genetic changes linked to lung cancer

Social living allows genetic effects to spread through the gut microbiome

Distant astrocytes found to play a key role in spinal cord repair

Intermittent fasting edges daily calorie cuts for blood pressure and long-term cardiovascular risk estimates

Early embryos and the uterus engage in active communication during implantation

How Traditional Chinese Medicine may reshape the gut microbiome to ease insulin resistance in PCOS

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production