Metabolism News and Research

Latest Metabolism News and Research

Study links ceramide levels to prostate cancer drug response differences

Ceramides-lipid molecules in cells that affect many physiological functions including cell differentiation, migration, and death-and their metabolites have been implicated in the development of cancer and other conditions.

26 May 2026

Ferroptosis exploits unique cancer metabolic vulnerabilities to bypass traditional apoptotic evasion pathways

A new wave of scientific understanding is placing ferroptosis, a distinct form of iron-dependent cell death, at the forefront of efforts to overcome drug resistance in digestive cancers. These cancers, which include gastric, colorectal, liver, pancreatic, and esophageal malignancies, remain among the most challenging to treat due to their ability to evade standard therapies.

25 May 2026

Metabolic reprogramming helps tumor cells adapt and evade the human immune system

A newly published review article highlights the critical role of fatty acid metabolism in shaping the tumor microenvironment and influencing cancer progression, offering fresh perspectives for the development of more effective therapies.

25 May 2026

New review highlights how glutamine metabolism shapes the complex tumor microenvironment

A new review article highlights the expanding importance of glutamine metabolism in shaping the tumor microenvironment, offering fresh perspectives on how metabolic interactions influence cancer progression and therapeutic response

25 May 2026

Researchers link surgical weight loss to reduced female cancer mortality rates

Substantial and sustained weight-loss has been linked to a reduced risk of cancer and cancer-related death, mainly in women. Two new studies now provide clues to why the risk is reduced - and suggest that gender, metabolism and genetics may play a crucial role.

25 May 2026

Scientists reveal why common pancreatic precancer lesions rarely turn deadly

Spatial and single-cell analyses of human donor pancreata showed that PanIN epithelial cells gradually acquire cancer-like molecular features, while their surrounding stromal and immune environment remains closer to normal pancreatic tissue. The findings suggest that delayed or incomplete microenvironmental reprogramming may help explain why most PanIN lesions remain indolent rather than progressing to pancreatic cancer.

24 May 2026

RNA regulator RBM15 linked to immunity, metabolism, and cancer progression

A newly published review article brings attention to the expanding role of RBM15, a critical regulator of RNA m6A methylation, in the development and progression of a wide range of diseases, including cancer, metabolic disorders, and cardiovascular conditions.

24 May 2026

Yoga and meditation show promise for gut health

This systematic review found that yoga and Buddhist meditation were associated with favorable gut microbiota and metabolite profiles in four human studies involving healthy adults. However, because participants largely followed vegetarian or vegan diets and no randomized controlled trials were included, the findings cannot prove that meditation alone reshapes the gut microbiome.

24 May 2026

Immunoproteasome plays emerging role in diabetes and metabolic complications

A newly published review article highlights the emerging importance of the immunoproteasome in the development and progression of diabetes and its wide-ranging complications, offering fresh perspectives on future therapeutic strategies.

24 May 2026

Pim1 identified as promising therapeutic target for inflammatory arthritis treatment

The research team led by Professor Zhongyu Xie from Sun Yat-sen University revealed a new mechanism by which Pim1 regulated Th17 cell differentiation through mitochondrial metabolism.

22 May 2026

Gene-based therapies could transform future pancreatitis treatment

Pancreatitis is a complex inflammatory disease driven by both genetic and environmental factors. It poses substantial clinical challenges due to a lack of disease-modifying therapies.

22 May 2026

University of Ottawa study links heart attacks with brain damage

A new study led by a team from the University of Ottawa takes a major step forward in understanding how a heart attack can dramatically reshape brain function and trigger neurological effects, from depression and anxiety to different types of cognitive decline.

22 May 2026

Scientists map genetic variants behind prostate cancer therapy failure

Recently, the research group led by Dr. Dechao Feng, Lecturer at University College London (UCL) and Distinguished Research Fellow at Zhejiang Provincial People's Hospital, published a review entitled "Intratumoral Androgens and Genetic Variants Driving Therapy Resistance in Prostate Cancer".

22 May 2026

Harvard researchers outline roadmap to solve orphan receptor challenge

A new review highlights how synthetic biology, AI, and spatial omics could transform ligand-receptor discovery from one-by-one searches into network-level mapping.

22 May 2026

Targeting lipid enzymes triggers starvation states in aggressive tumor cells

While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite.

22 May 2026

NIH researchers discover how weight-loss drugs alter brain cells

A team of researchers at the National Institutes of Health (NIH) have unveiled new details about the events GLP-1 receptor agonists trigger within neurons, which have been largely unexplored until now.

22 May 2026

Study supports routine childhood screening for type 1 diabetes

For ten years, the Fr1da study, coordinated by Helmholtz Munich, has been investigating whether early stages of type 1 diabetes in children can be detected in routine pediatric care.

21 May 2026

New study shows how exercise hormone reduces multiple sclerosis symptoms

A new study offers clues as to why exercise can improve neurological symptoms in people with multiple sclerosis (MS).

21 May 2026

Scientists discover how vitamin K pathway regulates bone remodeling

Bone is continuously renewed through a process known as bone remodeling, in which osteoblasts (bone-forming cells) build new bone, while osteoclasts (bone-resorbing cells) remove older mineralized tissue.

21 May 2026

Phase two clinical trial demonstrates dramatic mobility gains in children with severe fibrous dysplasia

Fibrous dysplasia is a rare skeletal disorder in which normal bone is gradually replaced by weak fibro-osseous tissue, leading to fractures, pain, deformities, and severe mobility impairment. In many patients, diseased bone tissue produces excessive amounts of fibroblast growth factor-23 (FGF23), a hormone that causes phosphate loss through the kidneys.

21 May 2026