T Cell News and Research

Latest T Cell News and Research

MITF protein may help develop effective drug treatments for melanoma

Scientists at The University of Manchester have identified a protein that appears to hold the key to creating more effective drug treatments for melanoma, one of the deadliest cancers.

From The University of Manchester 19 Dec 2012

Vismodegib team wins Drug Discovery of the Year award

The British Pharmacological Society proudly announces that its first annual Drug Discovery of the Year award has been won by the discovery team developing vismodegib for the treatment of basal cell carcinoma (a type of skin cancer).

19 Dec 2012

Ion channel acts as powerful ‘brake’ after epileptic seizures

Given that epilepsy impacts more than 2 million Americans, there is a pressing need for new therapies to prevent this disabling neurological disorder. New findings from the neuroscience laboratory of Mark S. Shapiro, Ph.D., at The University of Texas Health Science Center at San Antonio, published Dec. 20 in the high-impact scientific journal, Neuron, may provide hope.

19 Dec 2012

Cholesterol plays a key role in regulating proteins involved in cell signaling

Cholesterol plays a key role in regulating proteins involved in cell signaling and may be important to many other cell processes, an international team of researchers has found.

19 Dec 2012

Australian scientists receive grants for research on cancer, malaria and rheumatoid arthritis

Scientists at the Walter and Eliza Hall Institute in Melbourne, Australia, have received more than $16 million in Australian Government funding to pursue research into cancer, malaria, rheumatoid arthritis and the immune system, it was announced today.

19 Dec 2012

New antibiotic principle for fighting bacterial infections

Scientists at Karolinska Institutet in Sweden have presented a new principle for fighting bacterial infections, in other words, a new type of antibiotic, in the FASEB Journal.

19 Dec 2012

University of Maryland, Baltimore hosts first national conference on oral and systemic health

By hosting the first national conference on oral and systemic health in Baltimore on Dec. 10, the University of Maryland, Baltimore (UMB) took another major step toward true interprofessional health care education, says Jay A. Perman, MD, president of the University.

19 Dec 2012

Tumor cells manipulate unfolded protein response

Researchers at the University of California, San Diego School of Medicine report that tumor cells use stress signals to subvert responding immune cells, exploiting them to actually boost conditions beneficial to cancer growth.

19 Dec 2012

Targeting km23-1 protein may slow the spread of cancer cells

The spread of cancer cells may be slowed by targeting the protein km23-1, according to researchers at Penn State College of Medicine.

19 Dec 2012

Budding yeast an acceptable model system to study KP1019 anti-cancer drug

Researchers have found that the budding yeast (Saccharomyces cerevisiae) is an acceptable model system to study KP1019, an anti-cancer drug that uses ruthenium, a rare metal, a new study found. Researchers had previously been interested in studying KP1019 because it is believed to cause cancer cell death and is not known to have negative secondary side effects for healthy tissues.

19 Dec 2012

Metallic probe can detect fibrils from misfolded proteins in real time

Rice University scientists have discovered a new way to look inside living cells and see the insoluble fibrillar deposits associated with Parkinson's disease.

19 Dec 2012

EMD Serono's L-BLP25 Phase III NSCLC trial does not meet primary endpoint

EMD Serono, a subsidiary of Merck KGaA, Darmstadt, Germany, announced today that the Phase III STARTa trial of its investigational product L-BLP25 (formerly referred to as Stimuvax) in patients with unresectable, locally advanced stage IIIA or IIIB non-small cell lung cancer (NSCLC) did not meet its primary endpoint to demonstrate a statistically significant improvement in overall survival (OS).

19 Dec 2012

Riverside Methodist Hospital treats first PAD patient with Cook Medical's Zilver PTX device

Just weeks after the Food and Drug Administration (FDA) approved Cook Medical's Zilver PTX Drug-Eluting Peripheral Stent, Riverside Methodist Hospital in Columbus, Ohio, has treated the first patient with the device as part of Cook's U.S. commercial launch.

19 Dec 2012

Myostatin responsible for initiation of muscle loss: Study

A research study from Nanyang Technological University (NTU) has yielded important breakthroughs on how the body loses muscle, paving the way for new treatments for aging, obesity and diabetes.

19 Dec 2012

MiR-122 plays a critical role in the life cycle of hepatitis C virus

Hepatitis C virus has evolved to invade and hijack the basic machinery of the human liver cell to ensure its survival and spread. Researchers at the University of North have discovered how hepatitis C binds with and repurposes a basic component of cellular metabolism known as a microRNA to help protect and replicate the virus.

19 Dec 2012

Jagaricin and antifungal drugs: an interview with Prof Christian Hertweck

Most people have already experienced a fungal infection (mycosis) of the outer layer of the skin, athlete’s foot or ringworm. Whereas such infections may be cumbersome and often difficult to cure, usually they are not dangerous. However, in cases where a fungus causes a systemic infection, this is, it infects internal organs such as lungs or brain, the infection may turn into a life-threatening disease. Of course, only pathogenic fungi cause problems and the degree of virulence varies.

18 Dec 2012

Lymphocyte clue to multiple sclerosis drug response

Patients with rapid recovery of CD4-positive T cells after alemtuzumab treatment for multiple sclerosis are at risk for disease progression or relapse, research suggests.

18 Dec 2012

Scientists decode VEGF/Ang1/Syx pathway that regulates leakiness of blood vessels

A research team led by scientists at Mayo Clinic in Florida have decoded the entire pathway that regulates leakiness of blood vessels — a condition that promotes a wide number of disorders, such as heart disease, cancer growth and spread, inflammation and respiratory distress.

18 Dec 2012

BubR1 and its associated regulators promising targets for aging disorders and cancer

A new series of studies in mouse models by Mayo Clinic researchers uncovered that the aging process is characterized by high rates of whole-chromosome losses and gains in various organs, including heart, muscle, kidney and eye, and demonstrate that reducing these rates slows age-related tissue deterioration and promotes a healthier life span. The findings appear in today's online issue of Nature Cell Biology.

18 Dec 2012

MiR-181 molecule tied to breast cancer metastasis

Researchers at Case Western Reserve University School of Medicine have identified a molecule linked to more aggressive forms of breast cancer - a discovery that could point the way to potential cures.

18 Dec 2012