T Cell

T-cells are a critical component of the adaptive immune system and are indispensable in protecting humans from pathogenic infections.

Adoptive T Cell Therapy Methodology

Adoptive T cell therapy is a type of immunotherapy with the ability to target cancer cells through inherent mechanisms of the immune system. The method works by infusing tumor-specific cytotoxic T cells into patients which will recognize, target and attack tumor cells.

Adoptive T Cell Therapy Applications

T-Cell Metabolism, Immunodeficiency and Human Disease

CAR-T Cell Toxicity and Safety Profiles

T cells on the front line of COVID-19 response

In the new study, published in the journal Cell, the team has found that the uncoordinated responses produced by the immune system, especially in people who are more than 65 years old, maybe the reason why older adults are more at risk.

17 Sep 2020

Study shows how the body's immune system finds intruding or damaged cells

Research led by Dr. Wonmuk Hwang has led to better understanding on how components of the body's immune system find intruding or damaged cells, which could lead to novel approaches to viral and cancer treatments.

17 Sep 2020

Self-assembling nanoparticles as a way towards next-generation COVID-19 vaccines

In a promising study by US researchers, the receptor-binding domain (RBD) and stabilized spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were displayed on nanoparticles as vaccine antigens and elicited potent immune responses.

16 Sep 2020

Immunologists analyze types of immune response to predict an effective COVID-19 vaccine

Immune reactions caused by vaccination can help protect the organism, or sometimes may aggravate the condition.

15 Sep 2020

UofL receives $11.5 million to accelerate the development of new immunotherapies

Cancer remains one of the most difficult and deadly challenges in human health, affecting Kentuckians at a higher rate than residents of any other state and killing more than 600,000 people each year in the U.S. alone.

14 Sep 2020

New review explores the role of antibodies and T-cells towards an effective COVID vaccine

More than 100 companies have rushed into vaccine development against COVID-19 as the U.S. government pushes for a vaccine rollout at "warp speed" -- possibly by the end of the year -- but the bar set for an effective, long-lasting vaccine is far too low and may prove dangerous, according to Marc Hellerstein of the University of California, Berkeley.

11 Sep 2020

New antitumor vaccines control melanoma growth in preclinical models

Combining their expertise in protein engineering and synthetic DNA technology, scientists at The Wistar Institute successfully delivered nanoparticle antitumor vaccines that stimulated robust CD8 T cell immunity and controlled melanoma growth in preclinical models.

11 Sep 2020

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Researchers designed DLnano-vaccines displaying 60 copies of protein parts derived from the melanoma-specific antigens Trp2 and Gp100 and tested these in mouse models of melanoma, observing prolonged survival that depended on CD8 T cell activation both in therapeutic and prophylactic settings.

10 Sep 2020

Researchers identify proinflammatory lipids that precede onset of Type 1 diabetes in mouse model, children

Type 1 diabetes, or T1D, is an autoimmune disease in which the body's immune cells -; led by inflammatory macrophages -; attack and destroy the beta cells of the pancreas that produce insulin.

10 Sep 2020

Pfizer, BioNTech COVID-19 vaccine candidate shows promise in preclinical study

Researchers in the United States and Germany have conducted a study demonstrating the preclinical efficacy of a new candidate vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease 2019 (COVID-19).

9 Sep 2020

'Molecular brake' on the immune system could be potential treatment target for severe COVID-19

Older people and people with underlying medical conditions are at particular risk of severe COVID-19. A group of researchers from Charité - Universitätsmedizin Berlin have discovered one possible reason for this vulnerability.

8 Sep 2020

Study reveals complex immunology behind MIS-C in children with COVID-19

In a recent paper published in the prestigious journal Cell, researchers from Sweden and Italy show that inflammatory response in Multisystem Inflammatory Syndrome in Children associated with coronavirus disease (COVID-19) differs from the cytokine storm found in severe acute illness, involving autoantibodies at the same time and sharing several features with Kawasaki disease.

8 Sep 2020

The T cell responses in COVID-19 recovered individuals

A recent study demonstrates that functional CD4+ and CD8+ T cells specifically targeting the entire proteome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain active in individuals who have recovered from severe or mild coronavirus disease 2019 (COVID-19). Moreover, the magnitude of T cell response is correlated with the antibody response. The study is published in the journal Nature Immunology.

8 Sep 2020

Underlying pathology of MIS-C in children following SARS-CoV-2 infection

Researchers at the Icahn School of Medicine at Mount Sinai, New York, have conducted a study that sheds light on the molecular underpinnings of multisystem inflammatory syndrome in children (MIS-C).

3 Sep 2020

Scientists identify genetic risk factors underlying penicillin allergy

Penicillin, a life-saving medicine, is the most common cause of drug allergy, with clinical manifestations ranging from temporary skin reactions to life-threatening systemic syndromes.

3 Sep 2020

Exponential rise in COVID-19 hospitalization risk with age due to waning T cell immunity

The age-related increase in the risk of severe disease and death from COVID-19 mirrors earlier patterns seen with infections. Such trends may help understand the mechanisms underlying the clinical feature. A recent study published in the preprint server medRxiv* in August 2020 shows the effect of age and sex on COVID-19 hospitalization rates in the USA and helps understand how immune function is involved in this pandemic.

2 Sep 2020

Excessive immune response plays an important role in severe Covid-19

The team from Marien Hospital and the department of Virology of Ruhr-Universität Bochum (RUB) as well as the Clinic for Infectious Diseases, the Clinic of Anesthesiology and the Institute for Virology of University Medicine Essen studied specific antibodies and T cells occurring in recovered, seriously ill and deceased Covid-19 patients.

1 Sep 2020

New insights into why people suffer from nickel allergy

The cause of the allergic reaction are T lymphocytes (T cells). These cells are part of the body's defences and normally react to viruses or bacteria in the skin.

31 Aug 2020

Using SARS-CoV-2 epitope to construct a vaccine

A new study published on the preprint server bioRxiv* in August 2020 reports the use of prediction and advanced simulation techniques to identify a novel T cell epitope on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could serve as the basis for a customized vaccine with broad-based efficacy.

30 Aug 2020

Environmental surface testing at radiation oncology clinic showed no detectable SARS-CoV2

A Rutgers Cancer Institute of New Jersey study shows environmental surface testing at the center's Radiation Oncology Department located within Robert Wood Johnson University Hospital, an RWJBarnabas Health facility, during the height of the COVID-19 pandemic in the state showed no detectable SARS-CoV2 – the virus that causes COVID-19

28 Aug 2020

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T Cell

Overview

Adoptive T Cell Therapy Applications

T-Cell Metabolism, Immunodeficiency and Human Disease

CAR-T Cell Toxicity and Safety Profiles

Latest T Cell News and Research

T cells on the front line of COVID-19 response

Study shows how the body's immune system finds intruding or damaged cells

Self-assembling nanoparticles as a way towards next-generation COVID-19 vaccines

Immunologists analyze types of immune response to predict an effective COVID-19 vaccine

UofL receives $11.5 million to accelerate the development of new immunotherapies

New review explores the role of antibodies and T-cells towards an effective COVID vaccine

New antitumor vaccines control melanoma growth in preclinical models

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Researchers identify proinflammatory lipids that precede onset of Type 1 diabetes in mouse model, children

Pfizer, BioNTech COVID-19 vaccine candidate shows promise in preclinical study

'Molecular brake' on the immune system could be potential treatment target for severe COVID-19

Study reveals complex immunology behind MIS-C in children with COVID-19

The T cell responses in COVID-19 recovered individuals

Underlying pathology of MIS-C in children following SARS-CoV-2 infection

Scientists identify genetic risk factors underlying penicillin allergy

Exponential rise in COVID-19 hospitalization risk with age due to waning T cell immunity

Excessive immune response plays an important role in severe Covid-19

New insights into why people suffer from nickel allergy

Using SARS-CoV-2 epitope to construct a vaccine

Environmental surface testing at radiation oncology clinic showed no detectable SARS-CoV2

Delayed immune responses may be responsible for COVID-19 mortality rates

Are micro and nanoplastics accumulating in human organs and tissues?

A potential new way of treating Alzheimer’s Disease

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