T Cell News and Research

Latest T Cell News and Research

Proof-of-concept study holds promise for safer gene therapy techniques for treating immunodeficiencies

Researchers described an approach to edit the recombination-activating gene 2 (RAG2) locus for therapeutic applications.

1 Nov 2023

MHRA grants conditional marketing authorization for AbbVie's Tepkinly to treat aggressive blood cancer

AbbVie today announced that the UK Medicines and Healthcare products Regulatory Agency has granted conditional Marketing Authorisation for Tepkinly® (epcoritamab) as a monotherapy for the treatment of adults with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL), after two or more systemic therapies.

28 Oct 2023

Novel replacement strategy holds promise for the treatment of various genetic disorders

Severe Combined Immunodeficiencies (SCIDs) are a group of debilitating primary immunodeficiency disorders, primarily caused by genetic mutations that disrupt T-cell development. SCID can also affect B-cell and natural killer cell function and counts.

27 Oct 2023

Researchers discover new way to trigger programmed cell death in cancer cells

A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die.

24 Oct 2023

Intranasal vaccination: A potent one-time solution for comprehensive COVID-19 immunity

A single-dose intranasal vaccine effectively induces robust immune responses.

24 Oct 2023

Collaborative team receives NCI grant to study how to improve immunotherapy for diffuse midline gliomas

Each year, approximately 200 to 300 children in the United States are diagnosed with diffuse midline gliomas (DMG), a tumor that begins in the brain or spinal cord.

19 Oct 2023

CAR T-cell therapy for multiple myeloma shows no difference in survival outcomes by race and ethnicity

Patients with multiple myeloma treated with idecabtagene vicleucel, known as "ide-cel," a chimeric antigen receptor (CAR) T-cell therapy, had no difference in overall survival outcomes regardless of race and ethnicity, according to a study published in Blood Advances.

19 Oct 2023

New mRNA flu vaccine shows promise: Faster to produce, highly effective in mice

The study evaluates the efficacy of a new quadrivalent mRNA influenza vaccine, finding it to be highly immunogenic and protective in a mouse model. Compared to traditional vaccines, the mRNA-based option offers advantages like reduced production time and elimination of the risk of growth-promoting mutations.

15 Oct 2023

Are people with HIV at a higher risk of severe COVID-19 outcomes?

The research review indicates that people with HIV, especially those with low CD4 cell counts, face greater risks of severe COVID-19 outcomes and have suboptimal immune responses to SARS-CoV-2. Antiretroviral therapy aids in clearing infections, and a third vaccine dose reduces the risk of breakthrough infections among this population.

15 Oct 2023

IL-17: The molecule that could revolutionize autoimmune and cancer treatments

The research paper explores the multifaceted role of the IL-17 family in immune response, covering everything from infection control to pathological conditions like autoimmune diseases and cancer. Future therapies may exploit IL-17's unique signaling pathways to offer more targeted and cost-effective treatments.

12 Oct 2023

Unlocking hope: Promising treatments for cognitive impairment in HIV patients on the horizon

Researchers examine the mechanisms responsible for the increased risk of neurocognitive impairment in HIV patients and explore potential treatments.

12 Oct 2023

CT scan of the thymus reveals immune system aging

Thymus, a small and relatively unknown organ, may play a bigger role in the immune system of adults than was previously believed.

11 Oct 2023

New nanocapsule treatment boosts immune response against solid tumors

UCLA researchers have developed a new treatment method using a tiny nanocapsule to help boost the immune response, making it easier for the immune system to fight and kill solid tumors.

11 Oct 2023

Recent Advancements in Cell Based Therapy

In this interview, NewsMedical talks to James Brady about cell-based therapy and how the field of genetic engineering transformed.

From MaxCyte, Inc. 11 Oct 2023

COVID-19 vaccine response lower in patients with lung conditions, study finds

Clinicians and researchers at National Jewish Health studied COVID vaccine effectiveness in patients with underlying lung conditions such as asthma, chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD).

10 Oct 2023

Protein antigen from a childhood vaccine can help refocus the body's immune system against cancer

A University of Massachusetts Amherst team has demonstrated in theory that a protein antigen from a childhood vaccine can be delivered into the cells of a malignant tumor to refocus the body's immune system against the cancer, effectively halting it and preventing its recurrence.

10 Oct 2023

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

In the latest research published in Science Immunology, experts delve into the gene expression patterns of distinct intraepithelial lymphocyte populations in various gastrointestinal tract regions. Key findings reveal the roles of T-cell IELs in detecting infections and ensuring the gut's barrier integrity, with a special emphasis on their function in combating colon cancer.

9 Oct 2023

Next-gen intranasal vaccine takes on measles, mumps, and multiple COVID-19 variants in one shot

Researchers developed an intranasal trivalent measles-mumps-SARS-CoV-2 vaccine that provides robust protection against multiple coronavirus variants. Leveraging the established measles-mumps-rubella platform, this vaccine demonstrates broad and adaptable immune responses, especially against Delta and Omicron variants.

8 Oct 2023

Unlocking the future of cancer care: Overcoming challenges in personalized neoantigen vaccine development

Challenges associated with the development and design of neoantigen cancer vaccines.

5 Oct 2023

Research opens the door for better use of people's own immune system T cells to fight cancer

Using laboratory-grown cells from humans and genetically engineered mice, scientists at Johns Hopkins Medicine say they have evidence that modifying a specific protein in immune white blood cells known as CD8+ T cells can make the cells more robust, potentially opening the door for better use of people's own immune system T cells to fight cancer.

3 Oct 2023

T Cell News and Research

Latest T Cell News and Research

Proof-of-concept study holds promise for safer gene therapy techniques for treating immunodeficiencies

MHRA grants conditional marketing authorization for AbbVie's Tepkinly to treat aggressive blood cancer

Novel replacement strategy holds promise for the treatment of various genetic disorders

Researchers discover new way to trigger programmed cell death in cancer cells

Intranasal vaccination: A potent one-time solution for comprehensive COVID-19 immunity

Collaborative team receives NCI grant to study how to improve immunotherapy for diffuse midline gliomas

CAR T-cell therapy for multiple myeloma shows no difference in survival outcomes by race and ethnicity

New mRNA flu vaccine shows promise: Faster to produce, highly effective in mice

Are people with HIV at a higher risk of severe COVID-19 outcomes?

IL-17: The molecule that could revolutionize autoimmune and cancer treatments

Unlocking hope: Promising treatments for cognitive impairment in HIV patients on the horizon

CT scan of the thymus reveals immune system aging

New nanocapsule treatment boosts immune response against solid tumors

Recent Advancements in Cell Based Therapy

COVID-19 vaccine response lower in patients with lung conditions, study finds

Protein antigen from a childhood vaccine can help refocus the body's immune system against cancer

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

Next-gen intranasal vaccine takes on measles, mumps, and multiple COVID-19 variants in one shot

Unlocking the future of cancer care: Overcoming challenges in personalized neoantigen vaccine development

Research opens the door for better use of people's own immune system T cells to fight cancer

Immunology eBook

One Health, One Mission: The World Organisation for Animal Health on the AMR Frontline

Uniting Against Resistance: The World Health Organization for World Antimicrobial Awareness Week 2023

Tackling Antimicrobial Resistance: A Conversation with Dr. Beverley Isherwood

T Cell News and Research

Latest T Cell News and Research

Immunology eBook

One Health, One Mission: The World Organisation for Animal Health on the AMR Frontline

Uniting Against Resistance: The World Health Organization for World Antimicrobial Awareness Week 2023

Tackling Antimicrobial Resistance: A Conversation with Dr. Beverley Isherwood

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