Consumer Medicine Information
What is in this leaflet
This leaflet answers some of the common questions people ask about BRILINTA. It does
not contain all the information that is known about BRILINTA.
It does not take the place of talking to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor will have weighed the risks of
you taking BRILINTA against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.
What BRILINTA is used for
You have been given BRILINTA because you have had:
a heart attack, or
unstable angina (angina or chest pain that is not well controlled).
How BRILINTA works
BRILINTA contains a medicine called ticagrelor. This belongs to a group of medicines
called anti-platelet medicines.
Platelets are very small cells in your blood that help to stop bleeding. When a blood
vessel is damaged, they clump together to help form a blood clot. This stops bleeding.
However, clots can also form inside a damaged blood vessel. This can be very dangerous
the clot can cut off the blood supply completely - this can cause a heart attack (myocardial
infarction) or stroke.
the clot can partly block the blood vessels to the heart - this reduces the blood
flow to the heart. This can cause chest pain which comes and goes (called 'unstable
BRILINTA helps stop the clumping of platelets. This reduces the chance of a blood
clot forming that can block a blood vessel. This means that BRILINTA reduces the chance
of you having another heart attack, chest pain or stroke.
Your doctor will usually also tell you to take acetylsalicylic acid (aspirin). This
is another medicine, which affects platelets.
Your doctor will have explained why you are being treated with BRILINTA and told you
what dose to take.
Follow all directions given to you by your doctor carefully.
They may differ from the information contained in this leaflet.
Your doctor may prescribe this medicine for another use. Ask your doctor if you want
BRILINTA is only available on a doctor's prescription.
There is no evidence that BRILINTA is addictive.
Before you take BRILINTA
When you must not take it
You should not take BRILINTA if:
you have an allergy to any medicine containing ticagrelor or any of the ingredients
listed at the end of the leaflet.
Some of the symptoms of an allergic reaction may include, tightness of the chest,
wheezing, coughing or difficulty breathing, swelling of the face, lips, tongue or
other parts of the body; rash, itching or hives.
you have problems with bleeding, such as bleeding in your stomach or gut from an ulcer.
you have moderate to severe liver disease.
you have had a stroke caused by bleeding in the brain or a history of bleeding in
You are taking any of the following medicines:
ketoconazole (used to treat fungal infections), clarithromycin (used to treat bacterial
infections), nefazodone (an antidepressant), ritonavir and atazanavir (used to treat
HIV infection and AIDS).
the use by (expiry) date printed on the pack has passed or if the packaging is torn
or shows signs of tampering.
If you take this product after expiry date has passed, it may not work.
If it has expired or is damaged, return it to your pharmacist for disposal.
Do not take BRILINTA to treat any other complaint unless your doctor advises you to.
Do not give this medicine to anyone else.
BRILINTA is not recommended for children under 18 years of age, as its safety and
effectiveness in children have not been established.
Do not take BRILINTA if any of the above apply to you. If you are not sure whether
you should start taking this medicine, talk to your doctor.
Before you start to take it
Tell your doctor, dentist or pharmacist if:
you have allergies to any other medicines, foods, preservatives or dyes.
you have an increased risk of bleeding because of:
a recent serious injury
recent surgery (including dental work)
recent bleeding from your stomach or gut (such as stomach ulcer or colon polyps)
you have a condition that affects blood clotting
you have asthma or other lung problem or breathing difficulties
you are due to have surgery (including dental work) at any time while taking BRILINTA.
This is because of the increased risk of bleeding. Your doctor may want you to stop
taking BRILINTA for a short time.
you are on kidney dialysis
you have or have had high uric acid
you have a low heart rate
you have or have had any medical conditions.
you are pregnant or intend to become pregnant.
It is not recommended you take BRILINTA. Your doctor will discuss the risks and benefits
of taking BRILINTA during pregnancy.
you are breast feeding or intend to breast feed.
It is not recommended you take BRILINTA. Your doctor will discuss the risks and benefits
of taking BRILINTA during breast feeding.
If you have not told your doctor, dentist or pharmacist about any of the above, tell
them before you start taking BRILINTA.
Taking other medicines
Tell your doctor if you are taking any other medicines, including any that you get
without a prescription from your pharmacy, supermarket or health food shop.
Tell your doctor or pharmacist if you are taking any of the following medicines:
more than 40 mg daily of simvastatin (medicine used to treat high cholesterol)
rifampin (an antibiotic), phenytoin, carbamazepine and phenobarbital (used to control
seizures), dexamethasone (used to treat inflammatory and auto immune conditions),
digoxin (used to treat heart failure), cyclosporin (used to lessen your body's defences),
quinidine and diltiazem (used to treat abnormal heart rhythms), adenosine (used to
treat irregular heart rate), ergotamine (used to treat migraine), beta blockers and
verapamil (used to treat high blood pressure).
Tell your doctor or pharmacist if you are taking any medicines that may increase your
risk of bleeding. These medicines include:
"Oral anticoagulants" often referred to as "blood thinners" which include aspirin,
warfarin, clopidogrel and prasugrel.
"Fibrinolytics" and "Thrombolytics" often referred to as "clot-dissolvers" which include
streptokinase and tenecteplase.
Non-steroidal anti-inflammatory drugs (NSAIDs) often taken as pain killers such as
ibuprofen and naproxen.
Selective serotonin reuptake inhibitors (SSRIs) taken as antidepressants such as paroxetine,
sertraline and citalopram.
You may need different amounts of your medicines, or may need to take different medicines.
If you are unsure about any medicine you are taking you should check with your doctor
or pharmacist. They will have more information on medicines to be careful with or
avoid while taking BRILINTA.
How to take BRILINTA
Follow all directions given to you by your doctor carefully. They may differ from
the information contained in this leaflet.
If you do not understand the instructions in this leaflet, ask your doctor or pharmacist
How to take it
The starting dose is two tablets at the same time. This dose will usually be given
to you in the hospital. After that, the usual dose is one tablet twice a day.
Swallow each tablet whole with a drink of water.
If you have trouble swallowing BRILINTA tablets you can crush them and mix with water
Crush the tablet(s) to a fine powder using a mortar and pestle or other crushing device.
Add half a glass of water (approximately 100 mL) to the mortar and pestle/crushing
device and stir before pouring the liquid into a glass and drinking immediately.
For the remaining medicine, add another 100 mL to mortar and pestle/crushing device
and stir. Make sure you also stir the liquid in the glass before you drink it
If you are using a nasogastric tube because you cannot swallow at all:
Crush tablets in mortar and pestle/crushing device to a fine powder.
Add 50 mL of water to the mortar and pestle/crushing device and stir before withdrawing
the mixture into a syringe and administering the liquid through a nasogastric tube
For the remaining medicine, add another 50 mL to mortar and pestle/crushing device
and stir before withdrawing the mixture into the syringe and administering through
a nasogastric tube
Once all the medicine is used, flush the nasogastric tube with approximately 25 mL
of water to deliver any remaining contents of the in the tube into the stomach.
Your doctor will usually also tell you to take acetylsalicylic acid (aspirin). Your
doctor will tell you how much to take (usually 100 mg but may vary between 75-150
It does not matter whether you take BRILINTA with food or on an empty stomach.
Take your doses at around the same time every day. For example, one in the morning
and one in the evening.
Taking your tablets at the same time each day will have the best effect. It will also
help you to remember when to take it. You can check the day when you last took a tablet
of BRILINTA by looking at days on the blister. There is a sun (for the morning) and
a moon (for the evening). This will tell you whether you have taken the dose.
How long to take it
You should take BRILINTA for as long as your doctor tells you to.
If you forget to take it
If you forget to take a dose, take your next dose as normal. Then go back to taking
it as you would normally.
Do not double the dose (two doses at the same time) to make up for the forgotten dose.
If you have trouble remembering when to take your medicine, ask your pharmacist for
If you take too much (overdose)
Immediately telephone your doctor or the Poisons Information Centre (13 11 26) or
go to Accidents and Emergency at your nearest hospital, if you think that you or anyone
else may have taken too much BRILINTA even if there are no signs of discomfort or
poisoning. You may need urgent medical attention.
If you take too many BRILINTA tablets you may be at increased risk of bleeding.
While you are taking BRILINTA
Things you must do
Take BRILINTA exactly as your doctor has told you to.
Tell all doctors, dentists and pharmacists who are treating you that you are taking
If you are about to start taking any new medicines, tell your doctor and pharmacist
that you are taking BRILINTA.
Tell your doctor if you become pregnant while you are taking BRILINTA.
Tell your doctor if you decide to breast feed your baby.
Things you must not do
Do not stop taking BRILINTA without talking to your doctor. Take it for as long as
your doctor keeps prescribing it. If you want to stop taking BRILINTA, talk to your
This is because the benefits of BRILINTA are based on you taking it all the time.
If you stop taking BRILINTA without talking to your doctor it may increase the chance
of a heart attack or stroke or a blood clot forming.
Do not give this medicine to anyone else, even if they have symptoms that seem similar
Things to be careful of
Be careful driving or operating machinery.
BRILINTA is not likely to affect your ability to drive or use machines. You are being
treated because you had a heart attack or unstable angina and you may experience dizziness
and confusion. If you have these symptoms, you should be cautious while driving or
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are taking BRILINTA.
All medicines can have side effects. Sometimes they are serious, most of the time
they are not. You may need medical treatment if you get some of the side effects.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following:
Feeling short of breath
This is very common (affects more than 1 in 10 people). It might be due to your heart
disease or other cause, or it might be a side effect of BRILINTA. If your feeling
of shortness of breath gets worse or lasts a long time, tell your doctor. Your doctor
will decide if it needs treatment or further investigations.
Constipation, diarrhoea or indigestion
Feeling or being sick
Inflamed stomach (gastritis)
A tingling feeling
Tell your doctor immediately if you notice any of the following as you may need urgent
Signs of a stroke such as:
sudden numbness or weakness of your arm, leg or face, especially if only on one side
of the body.
sudden confusion, difficulty speaking or understanding others.
sudden difficulty in walking or loss of balance or co-ordination
suddenly feeling dizzy or sudden severe headache with no known cause.
These are signs of a kind of stroke caused by bleeding into the brain. This is uncommon
(affects less than 1 in 100 people).
Signs of bleeding, including:
Blood in your urine
Black stools or blood in your stools
Bleeding after surgery or from cuts and wounds that is more than normal
Some bleeding is common (affects less than 1 in 10 people). However, severe bleeding
is uncommon (affects less than 1 in 100 people), but can be life threatening.
If any of the following happen, tell your doctor immediately, or go to Accident and
Emergency at your nearest hospital:
tightness of the chest, wheezing, coughing or difficulty breathing.
swelling of the face, lips, tongue or other parts of the body.
severe skin reaction which may include rash, itching, redness, blistering or peeling
of the skin.
These are very serious side effects. If you have them, you may have had a serious
allergic reaction to BRILINTA. You may need urgent medical attention or hospitalisation.
The level of uric acid in your blood may increase while taking BRILINTA.
Your doctor may order blood tests to monitor the level of uric acid in your blood.
Tell your doctor if you notice anything else that is making you feel unwell.
Some people may get other side effects while taking BRILINTA.
Do not be concerned by this list of side effects. You may not get any of them. If
you experience any side effects, do not stop taking BRILINTA until you have spoken
with your doctor.
After using it
Keep your tablets in the blister pack until it is time to take them.
If you take BRILINTA out of the blister pack it will not keep well.
Keep it in a cool, dry place where the temperature stays below 30°C.
Do not store it or any other medicine in the bathroom or near a sink. Do not leave
it on a windowsill or in the car on hot days.
Heat and dampness can destroy some medicines.
Keep it where young children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place
to store medicines.
Ask your pharmacist what to do with any BRILINTA tablets you have left over if your
doctor tells you to stop taking them, or you find that the expiry date has passed.
What BRILINTA tablets look like
BRILINTA tablets are round, biconvex, yellow film-coated tablets for oral use with
"90" above "T" on one side and plain on the reverse.
BRILINTA is available in blister packs of 14 and 56 tablets.
Each BRILINTA tablet contains ticagrelor 90 mg as the active ingredient.
In addition to ticagrelor each BRILINTA tablet contains:
Calcium hydrogen phosphate dihydrate
Sodium starch glycollate
Iron oxide yellow (CI77492)
BRILINTA does not contain gluten.
AstraZeneca Pty Ltd
ABN 54 009 682 311
66 Talavera Road
MACQUARIE PARK NSW 2113
Telephone: 1800 805 342
Australian Registration Number
BRILINTA 90 mg - AUST R 167237
This leaflet was updated in December 2017.
BRILINTA is a registered trade mark of the AstraZeneca group of companies.
© AstraZeneca 2017
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