Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about DBL Dacarbazine for Injection.
It does not contain all the available information.
It does not take the place of talking to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor or pharmacist has weighed the risks
of you being given DBL Dacarbazine for Injection against the benefits they expect
it will have for you.
If you have any concerns about this medicine, ask your doctor or pharmacist.
Keep this leaflet in a safe place.
You may need to read it again.
What DBL Dacarbazine for Injection is used for
Dacarbazine belongs to a group of medicines known as antineoplastic or cytotoxic agents.
You may also hear it referred to as a chemotherapy medicine. Dacarbazine belongs to
a group of cytotoxics known as 'alkylating agents'.
Dacarbazine works by killing cancer cells and stopping cancer cells from growing and
DBL Dacarbazine for Injection is used to treat some types of melanomas (skin cancers)
and a type of cancer called sarcoma.
Your doctor may have prescribed DBL Dacarbazine for Injection for another reason.
Ask your doctor if you have any questions about why DBL Dacarbazine for Injection
has been prescribed for you.
This medicine may be used in combination with other medicines to treat cancer.
DBL Dacarbazine for Injection is available only with a doctor’s prescription.
Before you are given DBL Dacarbazine for Injection
When you must not be given it
You must not be given DBL Dacarbazine for Injection if you have an allergy to dacarbazine
or any of the ingredients listed at the end of this leaflet.
Symptoms of an allergic reaction to DBL Dacarbazine for Injection may include:
shortness of breath, wheezing or difficulty breathing
swelling of the face, lips, tongue or other parts of the body
rash, itching or hives on the skin.
You should not be given DBL Dacarbazine for Injection if you have or have had any
of the following medical conditions:
low white blood cell (WBC) count
problems with blood clotting
any blood disorder with a reduced number of red blood cells, white blood cells, or
Tell your doctor if you have an infection or high temperature.
Your doctor may decide to delay your treatment until the infection has gone. A mild
illness, such as a cold, is not usually a reason to delay treatment.
You should not be given dacarbazine if you are pregnant or intend to become pregnant.
Like most medicines used to treat cancer, dacarbazine is not recommended for use during
pregnancy, unless you and your doctor have discussed the risks and benefits involved.
Dacarbazine may cause birth defects if either the male or female is using it at the
time of conception. It is recommended that females use birth control while receiving
this medicine and for at least 6 months after stopping treatment. Males should use
birth control during and for at least 3 months after stopping treatment. Your doctor
will discuss this with you.
Many cancer medicines can cause infertility. Your doctor should discuss this issue
with you before you begin therapy with DBL Dacarbazine for Injection.
You should not be given DBL Dacarbazine for Injection if you are breast-feeding.
It is not known whether dacarbazine passes into breast milk. However, breast-feeding
is not recommended while you are being treated with dacarbazine.
If you are not sure whether you should be given DBL Dacarbazine for Injection, talk
to your doctor or pharmacist.
Before you are given it
Tell your doctor or pharmacist if you have allergies to:
any other medicines
any other substances, such as foods, preservatives or dyes.
Tell your doctor or pharmacist if you have or have had any medical conditions, especially
an infection, including shingles and chickenpox or a recent exposure to chickenpox
lowered immunity due to treatment with medicines such as corticosteroids, ciclosporin
or other medicines used to treat cancer (including radiation therapy).
Tell your doctor or dentist if you intend having any dental work while being treated
Dacarbazine may increase the incidence of infection, delayed healing and gum bleeding.
It is therefore recommended that any dental work be completed prior to starting dacarbazine
If you have not told your doctor about any of the above, tell them before you start
being treated with dacarbazine.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you buy without a prescription from your pharmacy, supermarket or health food
Some medicines and dacarbazine may interfere with each other. These include:
any medicines which suppress your immune system such as azathioprine, ciclosporin
some medicines used to treat gout, such as allopurinol
medicines used to treat epilepsy such as phenytoin and barbiturates
rifampicin, an antibiotic used to treat tuberculosis (TB)
levodopa, a medicine used in the treatment of Parkinson’s disease
other medicines used to treat cancer (such as mercaptopurine or fotemustine), radiation
therapy or any other treatment which lowers your immune system
some vaccines (ask your doctor).
These medicines may be affected by dacarbazine, or may affect how well it works.
You may need different amounts of your medicine, or you may need to take different
medicines. Your doctor or pharmacist will advise you.
Do not have any immunisations (vaccinations) while you are being treated with dacarbazine,
and for at least one year after you stop treatment, without your doctor’s approval.
Dacarbazine may lower your body’s resistance and there is a chance that you may get
the infection the immunisation is meant to prevent.
In addition, other people in close contact with you (such as other persons living
in your household) should not take oral polio vaccine (sabin) since there is a chance
they could pass the polio virus on to you.
Your doctor and pharmacist may have more information on medicines to be careful with
or avoid while you are being given Dacarbazine for Injection.
How DBL Dacarbazine for Injection is given
How much is given
Your doctor will decide what dose of dacarbazine you will receive. This depends on
your condition and other factors, such as your weight, height and if you are being
given any other chemotherapy medicines.
Dacarbazine for Injection may be given alone or in combination with other drugs.
Several courses of dacarbazine therapy may be needed, depending on your response to
Additional treatment may not be repeated until your blood cell numbers return to acceptable
levels and any uncontrolled effects have been controlled.
Ask your doctor if you want to know more about the dose of dacarbazine you receive.
How it is given
DBL Dacarbazine for Injection is given as a slow injection into a vein.
DBL Dacarbazine for Injection must only be given by a doctor or nurse.
How long it is given for
Dacarbazine is usually given in one of two different ways:
It may be given as a small daily dose for 10 days and repeated if needed, after 4
It may be given as a larger daily dose for 5 days and repeated if needed, after 3
Each group of smaller doses is called a ‘cycle’ of chemotherapy. Your doctor will
decide how many of these cycles you will need.
If you are given too much (overdose)
As Dacarbazine is given to you under the supervision of your doctor, it is very unlikely
that you will receive too much. However, if you experience severe side effects after
being given dacarbazine, tell your doctor immediately or go to the Accident and Emergency
department of your nearest hospital.
In case of overdose, immediately contact the Poisons Information Centre for advice
(telephone 13 11 26 in Australia, or call 0800 764 766 in New Zealand)
You may need urgent medical attention.
Symptoms of a dacarbazine overdose include the side effects listed below under ‘Side
Effects’, but are usually of a more severe nature.
While you are being given DBL Dacarbazine for Injection
Things you must do
Be sure to keep all your doctor’s appointments so your progress can be checked.
Your doctor may want to check your blood pressure and do some blood and other tests
from time to time to check on your progress and detect any unwanted side effects.
Keep follow up appointments with your doctor.
It is important to have your follow-up cycles of dacarbazine at the appropriate times
to get the best effects from your treatments.
Tell any other doctors, dentists, and pharmacists who are treating you that you are
being given dacarbazine.
If you are about to be started on any new medicine, tell your doctor, dentist or pharmacist
that you are being given dacarbazine.
If you plan to have surgery that needs a general anaesthetic, tell your doctor or
dentist that you are being given dacarbazine.
If you plan to be vaccinated within a year of being given dacarbazine, tell the doctor
before you are vaccinated.
If you become pregnant while you are being given dacarbazine, tell your doctor immediately.
Dacarbazine can lower the number of white blood cells and platelets in your blood.
This means that you have an increased chance of getting an infection or bleeding.
The following precautions should be taken to reduce your risk of infection or bleeding:
Avoid people with infections. Check with your doctor immediately if you think you
may be getting an infection, or if you get a fever or chills, cough or hoarse throat,
lower back or side pain, or find it painful or difficult to urinate;
Check with your doctor immediately if you notice any unusual bleeding or bruising,
black stools, blood in urine or stools or pinpoint red spots on your skin;
Be careful when using a toothbrush, dental floss or toothpick. Your doctor, dentist
or nurse may recommend other ways to clean your teeth and gums. Check with your doctor
before having any dental work done;
Be careful not to cut yourself when you are using sharp objects such as a safety razor
or fingernail or toenail cutters;
Avoid contact sports or other situations where bruising or injury may occur.
Your body breaks down dacarbazine and uses it to fight cancer. The breakdown products
may be excreted in body fluids and waste, including blood, urine, faeces, vomit and
In general, precautions to protect other people should be taken while you are receiving
chemotherapy and for one week after the treatment period by:
Flushing the toilet twice to dispose of any body fluids and waste
Wearing gloves to clean any spill of body fluid or waste. Use paper towels or old
rags, a strong solution of non-bleaching detergent and large amounts of water to mop
up the spill. Discard the towels or rags into a separate waste bag and dispose of
fluids in the toilet.
Wash linen or clothing that is heavily contaminated by body fluids or waste separately
from other items. Use a strong solution of non-bleaching detergent and large amounts
Place soiled disposable nappies and other pads in a plastic bag, seal and dispose
into the garbage.
For sexual intercourse, use a barrier method such as a condom.
Things to be careful of
Be careful driving or operating machinery until you know how dacarbazine affects you.
As with some other medicines, dacarbazine may cause dizziness, tiredness and confusion
in some people. Make sure you know how you react to dacarbazine before you drive
a car, operate machinery, or do anything else that could be dangerous if you are dizzy
or light-headed. If this occurs do not drive.
If you drink alcohol, dizziness or light-headedness may be worse.
Tell your doctor, pharmacist or nurse as soon as possible if you do not feel well
while you are being given DBL Dacarbazine for Injection.
Like other medicines that treat cancer, dacarbazine may have unwanted side effects,
some of which may be serious. You may need medical treatment if you get some of the
If you are over 65 years of age you may have an increased chance of getting side effects.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor, nurse or pharmacist if you notice any of the following and they
nausea, vomiting and loss of appetite
skin rash or itching
Tell your doctor immediately or go to the Accident and Emergency department of your
nearest hospital if you notice any of the following:
signs of infection, such as fever, chills, sore throat or mouth ulcers
pain or irritation at the injection site
symptoms of an allergic reaction, such as those listed at the start of this leaflet
severe abdominal pain
unusual bleeding or bruising (including blood in your stools or urine)
problems with urination eg. pain or difficulty
dizziness upon standing (due to a fall in blood pressure)
tingling, tremors or pain in your muscles
yellowing of the skin or eyeballs
severe nausea and vomiting
These are serious side effects. You may need urgent medical attention.
Temporary loss of hair, particularly that on the scalp is a less common side effect
of dacarbazine and occurs in a small number of patients. The severity of hair loss
will depend on the dose of dacarbazine given. It is more common when other anti-cancer
medicines are used together with dacarbazine.
Other side effects not listed above may occur in some patients.
Some of these side effects (for example, changes in blood cell count, blood pressure,
heart and liver function) can only be found when your doctor does tests from time
to time to check your progress.
Tell your doctor or pharmacist if you notice anything that is making you feel unwell.
Do not be alarmed by this list of possible side effects.
You may not experience any of them.
The benefits and side effects of dacarbazine may take some time to occur. Therefore
even after you have finished your dacarbazine treatment you should tell your doctor
immediately if you notice any of the side effects listed in this section.
After you have been given DBL Dacarbazine for Injection
DBL Dacarbazine for Injection will be stored in the pharmacy or on the ward. Store
between 2°C and 8°C. Refrigerate. Do not freeze. Protect from light.
What it looks like
DBL Dacarbazine for Injection is a white or very pale yellow powder which will be
mixed with Water for Injections before use. It comes in 20 mL amber glass vials.
citric acid monohydrate
Dacarbazine for Injection does not contain lactose, sucrose, gluten, tartrazine or
any other azo dyes.
Pfizer Australia Pty Ltd
Toll Free Number: 1800 675 229
DBL Dacarbazine for Injection is available in single packs in the following strength:
200 mg vials
AUST R 39954
This leaflet was updated in October 2022.
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