Diagnosis of Gender Dysphoria

Gender dysphoria is a condition where then person identifies himself or herself with the opposite of their original biological sex. This is not a mental disorder. However, some people may need therapy.

Diagnosis of gender dysphoria is thus important to rule out other concurrent or underlying mental disorders like anxiety, depression etc. (1)

A multidisciplinary team is required for diagnosis

Assessment of persons with gender dysphoria and diagnosis of the condition is a multidisciplinary action.

A detailed psychiatric history, psychosexual development and behavior history, neuropsychological testing and behavioral analysis may be needed.

The team may comprise of:

  • Psychiatrists
  • Psychologists
  • Neurologists
  • Endocrinologists (who specialize in hormonal functions)
  • Urologists (who specialize in the urinary tract and its abnormalities)
  • Behavioral and occupation therapists
  • Counsellors etc.

Gender dysphoria must be separated from homosexuality. Not all persons with gender dysphoria are homosexual. (1, 2)

Two phase diagnosis

Diagnosis may be a challenge since results of psychological testing may not be conclusive.

The International Harry Benjamin Gender Dysphoria Association lays down guidelines for a two phase diagnosis. (1)

  • Phase I – Diagnosis is based on the Diagnostic and Statistical Manual for Mental Disorders IV (Text Revision) or DSM – IV TR.
  • Phase II – Here the patient is assessed if he or she can live in the desired sex role permanently. This involves family information and counselling and name change. Hormonal therapy, gender re-assignation surgery and psychotherapy is administered as needed.

Ruling out other diagnosis

Differential diagnosis or other diagnosis that need to be ruled out during assessment of a suspected person with gender dysphoria include (1):–

  • Nonconformity to stereotypical sex role behaviors
  • Transvestic fetishism – The person may have a sexual fetish with cross dressing
  • Concurrent congenital intersex condition – The person may have ambiguous genitalia
  • Schizophrenia

Criteria for gender dysphoria diagnosis according to DSM V guidelines

The criteria for diagnosis according to the latest DSM V proposed guidelines is broken down into in children and in adolescents and adults. (3, 4):

DSM V diagnosis in children

In children –

  1. A definite difference between experienced/expressed gender and the one assigned at birth of at least 6 months duration. At least six of the following must be present:
    1. Persistent and strong desire to be of the other sex or insistence that they belong to the other sex
    2. In males a strong preference for cross-dressing and in female children a strong preference for wearing typical masculine clothing and dislike or refusal to wear typical feminine clothing
    3. Fantasising about playing opposite gender roles in make-belief play or activities
    4. Preference for toys, games, or activities typical of the opposite sex.
    5. Rejection of toys, games and activities conforming to one’s own sex. In boys avoidance of rough-and-tumble play and in girls rejection of typically feminine toys and activities
    6. Preference for playmates of the other sex
    7. Dislike for sexual anatomy. Boys may hate their penis and testes and girls dislike urinating sitting.
    8. Desire to acquire the primary and/or secondary sex characteristics of the opposite sex.
  2. The gender dysphoria leads to clinically significant distress and/or social, occupational and other functioning impairment. There may be an increased risk of suffering distress or disability.

    The subtypes may be ones with or without defects or defects in sexual development.

DSM V diagnosis in adults and adolescents

In adults and adolescents –

  1. A definite mismatch between the assigned gender and experienced/expressed gender for at least 6 months duration as characterized by at least two or more of the following features –
    1. Mismatch between experienced or expressed gender and gender manifested by primary and/or secondary sex characteristics at puberty
    2. Persistent desire to rid oneself of the primary or secondary sexual characteristics of the biological sex at puberty.
    3. Strong desire to possess the primary and/or secondary sex characteristics of the other gender
    4. Desire to belong to the other gender
    5. Desire to be treated as the other gender
    6. Strong feeling or conviction that he or she is reacting or feeling in accordance with the identified gender.
  2. The gender dysphoria leads to clinically significant distress and/or social, occupational and other functioning impairment. There may be an increased risk of suffering distress or disability.

    The subtypes may be ones with or without defects or defects in sexual development.

Further Reading

Last Updated: Jun 7, 2023

Dr. Ananya Mandal

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.


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  1. Henry Hall Henry Hall United States says:

    >>> This is not a mental disorder.

    Does that rather not beg the question as to why Gender Dysphoria absolutely is classified as a mental disorder in the DSM-5?  There are some "not very nice" possible answers to that rhetorical question. What is the real answer?

  2. Henry Hall Henry Hall United States says:

    That does rather beg the question as to why it is classified in DSM-5 as a mental disorder, in spite of not actually being a mental disorder.

  3. Anime Nightcore Anime Nightcore United States says:

    In the part where it was stating that children would want to to things typical of the opposite gender, I was furious, children probably are not completely aware of gender roles. Most (very) young children would be fine with another child wearing clothes of, or acting like, a child of the opposite gender. This should not be a requirement to be diagnosed.

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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