Hemolytic Uremic Syndrome (HUS) - Renal Disease

Hemolytic uremic syndrome (HUS) is a serious renal disease, and the most common etiologic factor in the development of acute renal failure in children. Most affected children are younger than 4 years old, but the disease may also occur in older children and even in adults.

HUS comprises a triad of disease conditions, namely:

  • Microangiopathic hemolytic anemia
  • Thrombocytopenia
  • Acute renal failure
Kidney from a case of hemolytic uremic syndrome due to E. Coli. Nephritis due to E Coli. Hemolytic uremia. Image Copyright: vetpathologist / Shutterstock
Kidney from a case of hemolytic uremic syndrome due to E. Coli. Nephritis due to E Coli. Hemolytic uremia. Image Copyright: vetpathologist / Shutterstock

Types of HUS

There are two types of HUS, as detailed below:

Typical HUS

Usually starting after a diarrheal episode, for which reason it was formerly also called D+HUS, it is a reaction produced by a strain of enteric bacterium called Escherichia coli (E.coli).

The specific variant is mostly Shiga toxin-producing E. coli (STEC) type 0157:H7. The children are usually between 6 months and 5 years, and have a history of watery diarrhea leading to hemorrhagic colitis 5-7 days before the onset of hemolysis and thrombocytopenia. Still later, the child develops oliguria or anuria.

Atypical HUS

This type is also called sporadic, showing no connection with a diarrheal episode (D-HUS), and seen mostly in adults. Many researchers suggest that other infections underlie this condition, such as human immunodeficiency virus (HIV) or pneumococcal infection.

Other contributing factors may include very severe forms of antiphospholipid syndrome or systemic lupus erythematosus. Some patients with atypical HUS following renal transplantation have developed it in reaction to calcineurin inhibitors.

Genetic forms of HUS are also included in atypical HUS. These include:

  • HUS associated with factor H deficiency
  • HUS due to membrane cofactor protein deficiency
  • HUS due to vWF-cleaving protease deficiency
  • HUS as a result of  defective intracellular vitamin B12 metabolism

Some atypical HUS cases show autosomal recessive or dominant patterns of heredity.

Clinical features

Most children with typical HUS first present with complaints such as abdominal pain, tenderness on palpation, nausea or vomiting and fever, but adults may not have any of these symptoms.

Diarrhea sets in later on, and after a week’s incubation the patient develops hemolysis and thrombocytopenia.


HUS is thought to be the outcome of hyperactivation of the complement system, which induces damage to the endothelial cells, mesangial cells, tubular epithelial cells in the kidney, monocytes and their derivatives.  


Since there is an incubation period between the diarrhea and the hemolysis, it is important to test the blood in every STEC-positive pediatric diarrhea patient for evidence of thrombocytopenia and hemolysis, and doing Shiga toxin testing to rule out infection with this strain of E. coli.

Stool culture is also important in establishing the presence of this microbe, from the public health perspective. There should be a high index of suspicion when the patient develops diarrhea following the ingestion of hamburgers, because contamination of hamburger meat with this bacterium is the commonest cause of HUS in the United States.


Treatment of HUS is symptomatic. Various therapies which are used in this condition include:

  • Parenteral fluids to prevent intravascular thrombosis which is characteristic of this disease. This may prevent further renal injury.
  • Nutritional support
  • Maintaining the fluid-electrolyte balance
  • Monitoring the platelet count and hematocrit
  • Red blood cell transfusion if anemia develops to prevent deterioration in the condition and cardiorespiratory collapse
  • Platelet transfusions are not recommended to prevent thrombosis
  • Support for thrombocytopenia and renal failure
  • Eculizumab is a complement inhibitor which has shown promising results in the form of rapid improvement of blood test results, as well as better long-term renal function.
  • Avoid drugs such as antibiotics, bowel binders, narcotics and NSAIDs (non-steroidal anti-inflammatory drugs) while the disease is in the acute phase.


In children, HUS may result in complications such as intussusception, chronic renal failure, and involvement of the central nervous system followed by epileptic seizures, coma, hemiparesis or stroke.


Completely recovery occurs in up to 85% of patients with D+HUS. Up to 12% of patients will die or enter end-stage renal disease. Recurrence of the illness is rare. D-HUS has a worse prognosis, and most patients do not recover completely.


At present the only mode of prevention is by avoiding primary infection with the bacterium.


Further Reading

Last Updated: Feb 26, 2019

Dr. Liji Thomas

Written by

Dr. Liji Thomas

Dr. Liji Thomas is an OB-GYN, who graduated from the Government Medical College, University of Calicut, Kerala, in 2001. Liji practiced as a full-time consultant in obstetrics/gynecology in a private hospital for a few years following her graduation. She has counseled hundreds of patients facing issues from pregnancy-related problems and infertility, and has been in charge of over 2,000 deliveries, striving always to achieve a normal delivery rather than operative.


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