Hyperthyroidism Diagnosis

Hyperthyroidism is a health condition which results from the overactivity of the thyroid gland. It can be diagnosed by the presenting history and a physical examination, in addition to several tests to confirm the diagnosis and investigate the cause of the condition.

Physical Examination

A physical examination is an important part of the diagnostic process to investigate for any signs or symptoms that may be indicative of hyperthyroidism. Typical symptoms of hyperthyroidism may include:

  • Enlarged thyroid gland
  • Heart palpitations
  • Hand tremor
  • Clammy skin
  • Increased appetite with loss of weight
  • Protrusion of the eyes

An enlarged thyroid gland is often visible, particularly in more severe cases. It appears as a lump or several lumps at the front of the base of the neck, below the voice box.

It is also important that the patient consultation allows the individual to report any other symptoms that may be related to the condition, such as nervousness or skin changes. Hyperthyroidism can cause a range of symptoms, depending on the specific case.

Symptoms of thyrotoxicosis range from warm moist skin and staring eyes, to tremors of the outstretched arm and muscle weakness.

Hyperthyroidism or over active thyroid. Hyperthyreosis. Signs and Symptoms thyroid dysfunction - Image Copyright: Designua / Shutterstock
Hyperthyroidism or over active thyroid. Hyperthyreosis. Signs and Symptoms thyroid dysfunction - Image Copyright: Designua / Shutterstock

Examination of the eyes and the skin

Approximately half of patients with Graves’ disease have eye symptoms such as protruding eyes, difficulty in complete lid closure, swelling of the conjunctiva and double vision. Pretibial myxedema refers to thickening of the skin over  the lower leg.

Thyroid Function/Blood Tests

Blood test to measure the concentration of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), in addition to thyroid stimulating hormone (TSH), are essential to confirm the diagnosis of hyperthyroidism. This also helps to narrow down the diagnosis and exclude other conditions with similar symptoms.

Individuals with hyperthyroidism will have unique blood test results, showing a low concentration of TSH and high levels of T3 and T4. TSH is usually secreted from the pituitary gland and stimulates the thyroid gland to produce more hormones. In hyperthyroidism, the levels of thyroid hormones are higher than normal, despite lower than normal TSH production.

Some individuals may have blood test results which show normal levels of T3 and T4 but lower levels of TSH than normal. This is known as subclinical overactive thyroid gland. This condition does not usually require treatment, and often the hormone levels return to normal spontaneously within several weeks or months. It is best to monitor the hormone levels and manage appropriately if the T3 and T4 concentrations become elevated.

Iodine Uptake Scan

The iodine uptake scan helps to measure the function of the thyroid gland by measuring the amount of iodine that is taken up by the gland to produce the thyroid hormones.

This test involves administration of a small dose of radioactive iodine on an empty stomach. Over the following hours, the iodine is then taken up into the thyroid gland or excreted in the urine. The concentration in the thyroid gland is used as an indicator of hyperthyroidism.

Thyroid Scan

This test also involves the administration of radioactive iodine that is taken up by the thyroid gland. The scan then uses gamma ray emissions from the radioactive iodine to construct an image, or scintigram, of the thyroid gland structure.

As both the iodine uptake scan and the thyroid scan involve the administration of radioactive iodine, both tests are usually undertaken at the same time during the diagnostic process.

Determining the Cause

It is also important to identify the likely cause of hyperthyroidism during the diagnostic process, as this will help to guide the treatment decisions. Possible causes include:

  • Graves’ disease
  • Thyroid nodules (goiter)
  • Thyroiditis
  • Iodine supplementation
  • Drugs such as amiodarone
  • Thyroid cancer

Each of these types of hyperthyroidism has a unique cause, which should be addressed to normalize the function of the thyroid gland. This may include changing medications such as amiodarone or iodine supplements, or surgery to remove abnormal growth of the thyroid gland.


Further Reading

Last Updated: Feb 26, 2019

Yolanda Smith

Written by

Yolanda Smith

Yolanda graduated with a Bachelor of Pharmacy at the University of South Australia and has experience working in both Australia and Italy. She is passionate about how medicine, diet and lifestyle affect our health and enjoys helping people understand this. In her spare time she loves to explore the world and learn about new cultures and languages.


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