Klinefelter Syndrome Treatment

As there is no cure for Klinefelter syndrome, the treatment of the condition focuses on improving symptoms and providing support to the individual. Treatment should be commenced as soon as possible following diagnosis to minimize complications associated with the condition.

Therapy often involves a multidisciplinary team to address the various aspects of the condition, including an endocrinologist, pediatrician, speech therapist, physical therapist, occupational therapist, psychologist, and infertility specialist.

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Hormonal therapy

Hormonal androgen therapy is the most important part of treatment that helps to increase testosterone levels and induce natural changes at the usual age of puberty which is approximately 12 years of age. This can help to increase physical strength, facial hair growth, libido, and testicle size. It also can improve the mood, self-confidence, and behavior of the affected individual.

The dose used in the patient's hormonal therapy needs to be tailored to the patient to sufficiently maintain the appropriate concentrations of testosterone, estradiol, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) for the patient's appropriate age. There are various formulations available, including an injection, gel, or patch. The treatment will need to continue for the lifetime of the patient to maintain control over their symptoms.

Not all males with Klinefelter syndrome will require testosterone therapy. Some patients only have a slightly reduced level of testosterone; therefore, the benefits of therapy may not justify the risk of the medication. Side effects of hormonal androgen therapy may include acne, skin rash, breathing problems, and an increased risk of an enlarged prostate gland or prostate cancer in later years.


Until recently, the vast majority of men with Klinefelter syndrome were considered to be infertile. However, approximately half of men with the condition have the presence of sperm in their testes, which indicates the possibility of reproduction.

Advances in artificial reproductive technologies have increased the probability that affected patients can have biological children. This is possible through microsurgical testicular sperm extraction (TESE) and in-vitro fertilization (IVF).

Sperm is present in the testes of most men with Klinefelter syndrome and can be extracted with a surgical biopsy known as TESE. The spermatozoon can then be injected directly into an ovum with the help of IVF. As a result of these techniques, up to 25% of men with Klinefelter syndrome are now able to have biological children.

Other treatments

There are several other treatment modalities that may be useful for men with Klinefelter syndrome. These include:

  • Speech therapy to improve speech impairments, particularly in children
  • Physical therapy to improve muscle tone and motor skills        
  • Occupational therapy to improve balance and coordination in boys with dyspraxia
  • Cosmetic therapy to remove unwanted breast tissue (mastectomy)
  • Counseling to provide emotional and psychological support

As many men with Klinefelter syndrome suffer from depression and other psychological disorders, it is important that they have good access to health support in this area. A psychologist or counselor can help patients to adjust to changes and cope with problems related to the condition and life circumstances.

Many boys with Klinefelter syndrome also have learning difficulties and may benefit from educational support. Teachers and other people involved in the children’s education should be aware of the condition and assist in improving the learning environment where possible.

What is Klinefelter syndrome? - Prof Rob McLachlan


Further Reading

Last Updated: Apr 13, 2021

Yolanda Smith

Written by

Yolanda Smith

Yolanda graduated with a Bachelor of Pharmacy at the University of South Australia and has experience working in both Australia and Italy. She is passionate about how medicine, diet and lifestyle affect our health and enjoys helping people understand this. In her spare time she loves to explore the world and learn about new cultures and languages.


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