Tay-Sachs Disease Symptoms

Infants who are affected by Tay-Sachs disease usually begin to show signs of the disease at approximately six months of age. There are two other forms of the disease including juvenile and late-onset Tach-Sachs disease, which are categorized according to the age of the patients when symptoms present.

What is Tay-Sachs Disease? (GM2 Gangliosidosis)

Infantile Tay-Sachs disease

Infantile Tay-Sachs disease is the most common type of the disease. Although nerve damage is likely to begin in utero, signs usually become evident later in life at the age of about six months.

The initial signs of infantile Tay-Sachs disease may include:

  • A red dot visible near the center of the retina
  • Poor vision
  • Increased startle response
  • Delayed learning development (e.g. sitting and crawling)

The progression of the disease tends to occur quickly, with signs and symptoms quickly evolving to become more serious. Other symptoms may include:

  • Muscle weakness
  • Dysphagia
  • Muscular spasticity
  • Disinterest in environment
  • Susceptible to infection
  • Vision loss
  • Seizures
  • Paralysis

Infants with Tay-Sachs disease are more vulnerable to infections than other children, with this risk increasing as the disease progresses. An infection of the lungs, such as pneumonia, is the primary cause of death for many children with the disease. Furthermore, this is the primary cause of the reduced life expectancy associated with infantile-onset of the disease.

Most children with the first signs of Tay-Sachs disease in infancy do not survive beyond the age of four years as a result of the severity of the symptoms and repeated infections.

Juvenile Tay-Sachs disease

Some children with Tay-Sachs disease will not begin to notice symptoms until after six months of age. In fact, children with this form of Tay-Sachs known as juvenile Tay-Sachs disease will instead begin to show symptoms between the age of two and ten years old.

The initial signs that present usually involve difficulty in the development of speech and motor skills. Affected children commonly struggle with learning to move and walk due to problems of balance. Additionally, children with this juvenile form of the disease may have trouble swallowing and learning to talk as a result of the condition.

Problems with and eventual loss of vision are also commonly evident. Most children suffer from fits when the disease has progressed and have signs of dementia with a difficult memory.

Over time, children with juvenile Tay-Sachs disease tend to lose signs of awareness and are eventually unable to interact with their surrounding environment. In early adolescence, most children reach a vegetative state and usually die of a complication, such as a lung infection.

Late-onset Tay-Sachs disease

In this form of the disease, symptoms tend to present in adolescence or early adulthood. Common symptoms include:

  • Speech difficulties
  • Reduced coordination and balance
  • Severe tremor
  • Muscle weakness
  • Cramps and twitching

Approximately one-third of patients with the late-onset form of this disease tend to develop mental health conditions. These patients usually experience hallucinations or delusions and may also be diagnosed with bipolar disorder or psychosis.

This is the least severe form of Tay-Sachs disease and is not usually associated with fatal complications. Instead, patients with late-onset Tay-Sachs are characterized by symptoms that inhibit their quality of life. Moreover, this form of the disease is associated with slower progression and the life expectancy of individuals with this form of the disease varies greatly.


Further Reading

Last Updated: Apr 18, 2021

Yolanda Smith

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Yolanda Smith

Yolanda graduated with a Bachelor of Pharmacy at the University of South Australia and has experience working in both Australia and Italy. She is passionate about how medicine, diet and lifestyle affect our health and enjoys helping people understand this. In her spare time she loves to explore the world and learn about new cultures and languages.


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  1. M. Owais M. Owais Islamic Republic of Pakistan says:

    I wanted to know that what are the symptoms in tay-sachs carrier parents? Check up from Dor Yeshorim http://doryeshorim.org/process/ or any other reputable organization can really prevent our children from tay-sachs?

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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