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Scientists identify key factor that drives resistance to cancer drug

Developing resistance to chemotherapy is a nearly universal, ultimately lethal consequence for cancer patients with solid tumors - such as those of the breast, prostate, lung and colon - that have metastasized, or spread, throughout the body. A team of scientists led by Fred Hutchinson Cancer Research Center has discovered a key factor that drives this drug resistance - information that ultimately may be used to improve the effectiveness of therapy and buy precious time for patients with advanced cancer.

6 Aug 2012

Associate director of Clinical Genetics receives Angelo DiGeorge Medal of Honor

Donna McDonald-McGinn, M.S., CGC, associate director of Clinical Genetics and program director of the "22q and You" Center at The Children's Hospital of Philadelphia, received the Angelo DiGeorge Medal of Honor on July 6 at the 8th Biennial International 22q11.2 DS Conference in Lake Buena Vista, Florida. Ms. McDonald-McGinn, who began her career at CHOP in 1985, is the second person to receive this highly esteemed honor.

6 Aug 2012

Genocea announces new data that supports novel approach for development of HSV-2 vaccine

Genocea Biosciences announced today the presentation of new data supporting its novel approach to developing a first-in-class, protein subunit therapeutic vaccine for Herpes Simplex Virus type 2 (HSV-2).

6 Aug 2012

Astellas announces closure of Urogenix research facility

Astellas Pharma Inc. announced that it decided to close Urogenix, Inc., an Astellas subsidiary, which is a research facility focusing on drug discovery in the field of urology.

6 Aug 2012

Study focuses on factors related to obesity in nurses with adverse work schedules

For nurses who work long hours or other "adverse work schedules," the risk of obesity is related to lack of opportunity for exercise and sleep, suggests a study in the August issue of Journal of Occupational and Environmental Medicine, the official publication of the American College of Occupational and Environmental Medicine (ACOEM).

6 Aug 2012

Prior contralateral amputation predicts outcomes after LEB for critical limb ischemia

Researchers from the Vascular Study Group of New England (VSGNE) report that prior contralateral amputation predicts worse outcomes for lower extremity bypasses (LEB's) performed in the intact limb.

6 Aug 2012

Computerized brain fitness program improves memory and language skills in older adults

UCLA researchers found that older adults who regularly used a brain fitness program played on a computer demonstrated significantly improved memory and language skills.

6 Aug 2012

Montefiore launches first fellowship program in Women's Physical Medicine and Rehabilitation

Montefiore Medical Center has launched the nation's first fellowship program in Women's Physical Medicine and Rehabilitation (WPM&R), and established a new clinical program in this specialty.

6 Aug 2012

Public Health Wales uses Luminex's xTAG GPP for outbreak investigations during Olympic events

Luminex Corporation announced today that Public Health Wales is using Luminex's CE marked xTAG Gastrointestinal Pathogen Panel (GPP) for outbreak investigation activities during Olympic and Paralympic training and events taking place in Wales. Results of a substantial diagnostic validation of the GPP test conducted by The Public Health Wales Microbiology laboratory team at the University Hospital of Wales, Cardiff, are anticipated to be published in a peer reviewed journal

From Luminex 6 Aug 2012

New sequencing approach can provide more effective method of BRCA1/2 mutational analysis

Individuals with mutations in BRCA1 and BRCA2 genes have a significantly higher risk of developing breast and ovarian cancers. Families at risk have been seeking genetic testing and counseling based on their mutation carrier status, but the standard method of direct sequencing is labor-intensive, costly, and it only targets a part of the BRCA1 and BRCA2 genes.

6 Aug 2012

Neutrophils play an unexpected role in mediating insulin resistance

Researchers at the University of California, San Diego School of Medicine say neutrophils, an abundant type of white blood cell typically tasked with attacking bacteria and other foreign invaders, also plays an unexpected role in mediating insulin resistance - the central characteristic of type 2 diabetes, which afflicts an estimated 26 million Americans.

6 Aug 2012

UCSF/SFGH report addresses widespread gaps in health literacy and shows how to bridge them

Is it possible for a health care system to redesign its services to better educate patients to deal with their immediate health issues and also become more savvy consumers of medicine in the long run? The answer is yes, according to a study led by scientists at the University of California, San Francisco (UCSF) and San Francisco General Hospital and Trauma Center (SFGH) that was recently reported by the Institute of Medicine (IOM).

6 Aug 2012

Researchers make major advance in efforts to regenerate damaged hearts

Researchers have made a major advance in efforts to regenerate damaged hearts. Grafts of human cardiac muscle cells, grown from embryonic stem cells, coupled electrically and contracted synchronously with host muscle following transplantation in guinea pig hearts.

6 Aug 2012

Novartis, Penn partner to study and commercialize novel cellular immunotherapies for cancer

In an alliance aimed at bringing a new, personalized immunotherapy approach to patients with a wide variety of cancers, the University of Pennsylvania and Novartis announced today an exclusive global research and licensing agreement to further study and commercialize novel cellular immunotherapies using chimeric antigen receptor (CAR) technologies.

6 Aug 2012

TAU research identifies protein group that may kick-start allergic reactions

Allergies, or hypersensitivities of the immune system, are more common than ever before. According to the Asthma and Allergies Foundation of America, one in five Americans suffers from an allergy - from milder forms like hay fever to more severe instances, like peanut allergies which can lead to anaphylactic shock.

6 Aug 2012

First generic versions of Singulair receive FDA approval for treatment of asthma, allergies

The U.S. Food and Drug Administration today approved the first generic versions of Singulair (montelukast sodium) for use in adults and children to control asthma symptoms and to help relieve symptoms of indoor and outdoor allergies.

6 Aug 2012

Human HLA genes are evolving much more rapidly than previously thought

Human HLA genes - the genes that allow our immune system to tell the difference between our own cells and foreign invaders - are evolving much more rapidly than previously thought, according to an article online on August 3rd in Trends in Genetics. The resulting degree of variation improves our ability to fight off disease, but could also present challenges to current worldwide efforts aimed at identifying potential donors for patients undergoing stem cell transplantation.

6 Aug 2012

Mammalian cells divide when their growth rate hits a specific threshold

It's a longstanding question in biology: How do cells know when to progress through the cell cycle? In simple organisms such as yeast, cells divide once they reach a specific size. However, determining if this holds true for mammalian cells has been difficult, in part because there has been no good way to measure mammalian cell growth over time.

6 Aug 2012

Playfulness may serve an evolutionary role in human mating preferences

Why do adults continue to play throughout their lives while most other mature mammals cease such behavior? According to researchers at Penn State, playfulness may serve an evolutionary role in human mating preferences by signaling positive qualities to potential long-term mates.

6 Aug 2012

Sanofi-aventis receives FDA approval for Zaltrap to treat colorectal cancer

The U.S. Food and Drug Administration today approved Zaltrap (ziv-aflibercept) for use in combination with a FOLFIRI (folinic acid, fluorouracil and irinotecan) chemotherapy regimen to treat adults with colorectal cancer.

6 Aug 2012

Medical News

Scientists identify key factor that drives resistance to cancer drug

Associate director of Clinical Genetics receives Angelo DiGeorge Medal of Honor

Genocea announces new data that supports novel approach for development of HSV-2 vaccine

Astellas announces closure of Urogenix research facility

Study focuses on factors related to obesity in nurses with adverse work schedules

Prior contralateral amputation predicts outcomes after LEB for critical limb ischemia

Computerized brain fitness program improves memory and language skills in older adults

Montefiore launches first fellowship program in Women's Physical Medicine and Rehabilitation

Public Health Wales uses Luminex's xTAG GPP for outbreak investigations during Olympic events

New sequencing approach can provide more effective method of BRCA1/2 mutational analysis

Neutrophils play an unexpected role in mediating insulin resistance

UCSF/SFGH report addresses widespread gaps in health literacy and shows how to bridge them

Researchers make major advance in efforts to regenerate damaged hearts

Novartis, Penn partner to study and commercialize novel cellular immunotherapies for cancer

TAU research identifies protein group that may kick-start allergic reactions

First generic versions of Singulair receive FDA approval for treatment of asthma, allergies

Human HLA genes are evolving much more rapidly than previously thought

Mammalian cells divide when their growth rate hits a specific threshold

Playfulness may serve an evolutionary role in human mating preferences

Sanofi-aventis receives FDA approval for Zaltrap to treat colorectal cancer

The importance of ketones from a clinical and medical perspective

How Programmable Nanobiology Could Drive the Fifth Industrial Revolution

Dr. Anthony Grice

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